The Incidence of Vascular Dementia in Canada: A Comparison with Europe and East Asia

Dubois, Marie‐France; Hébert, Réjean

doi:10.1159/000054785

Cited by 78 publications

(44 citation statements)

References 48 publications

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“…Despite advances in medica-tion and other forms of treatment, vascular disease remains the primary cause in 20% of all dementia cases, 16 and is commonly a significant contributing factor in other neurodegenerative processes. This fact underscores the importance of finding new ways to identify and treat those individuals who are at greatest risk for developing vascular cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Performance Is Associated With Vascular Function in Patients With Atherosclerotic Vascular Disease

Moser

Robinson

Hynes

et al. 2007

ATVB

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Objective-We previously reported preliminary data (Nϭ14) demonstrating a significant and positive relationship between forearm vascular function and neuropsychological performance in individuals with atherosclerotic vascular disease (AVD). The current study was conducted to confirm and extend those findings in a much larger, nonoverlapping sample. Methods and Results-Participants were 82 individuals with AVD, with no history of stroke, cardiac surgery, or dementia.Forearm vascular function was measured before and after brachial artery infusion of vasoactive agents (acetylcholine, nitroprusside, verapamil

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Section: Discussionmentioning

confidence: 99%

Neuropsychological Performance Is Associated With Vascular Function in Patients With Atherosclerotic Vascular Disease

Moser

Robinson

Hynes

et al. 2007

ATVB

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“…With the incidence and prevalence of dementia escalating and limited resources for management, there is an increasing need to identify those who are at risk of developing dementia so that early interventions may be initiated [1,2]. Progression to dementia can be measured as a change in diagnostic status or as a deterioration in cognitive ability as indicated by a test score.…”

Section: Introductionmentioning

confidence: 99%

Identifying and Characterizing Trajectories of Cognitive Change in Older Persons with Mild Cognitive Impairment

Xie

Mayo²,

Koski³

2011

Dement Geriatr Cogn Disord

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Background: Mild cognitive impairment (MCI) represents a state of high risk for dementia but is heterogeneous in its course. To date, the trajectories reflecting distinct developmental courses of cognition among patients with MCI have not been well defined. Aim: To identify the developmental trajectory of groups with distinct cognitive change patterns among a cohort of MCI patients. Methods: 187 MCI patients from 2 geriatric outpatient clinics were evaluated serially with the Mini-Mental State Examination (MMSE) for up to 3.5 years. Group-based trajectory analysis was applied to identify distinct trajectories. Estimates of decline for each group were compared with the mean rate of decline obtained from mixed modeling of the entire sample. Results: 5 trajectories were identified and labeled based on their baseline MMSE score and course: (1) 29/stable (6.5%); (2) 27/stable (53.9%); (3) 25/slow decline (23.8%); (4) 24/slow decline (11.6%); (5) 25/rapid decline (4.2%). Annual rate of change in the MMSE score for these 5 groups was 0.09, –0.43, –1.23, –1.84, and –4.6 points, respectively. None corresponded to the mean rate of –0.82 points estimated for the group as a whole. A majority of MCI patients (60.4%) follow stable cognitive trajectories over time. Within the 3 groups with declining trajectories, cognitive decline occurs slowly in a vast majority of MCI patients (98.5%). Conclusions: Results provide direct evidence for the heterogeneous course of cognitive decline that has been suggested by the variable prognosis for patients with MCI.

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“…Vascular dementia (VaD) is the second largest cause of dementia in the elderly after Alzheimer’s disease (AD), representing 15–20% of all cases of dementia worldwide [1, 2]. VaD may result from cerebrovascular disease (CVD), including ischemic or hemorrhagic strokes, as well as from hypoperfusive ischemic cerebral injury resulting from cardiovascular and circulatory disorders [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Vascular Dementia Prevention: A Risk Factor Analysis

Román¹

2005

Cerebrovasc Dis

131

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Brain injury from ischemic or hemorrhagic cerebrovascular disease (CVD) produces decline in cognitive functions and vascular dementia (VaD). Likewise, CVD may cause VaD from hypoperfusion of susceptible brain areas. CVD may also worsen degenerative dementias such as Alzheimer’s disease. Significant advances have been made in the identification and control of risk factors for stroke and cardiovascular disease. The main risk factors for VaD include age, hypertension and absence of antihypertensive medication, diabetes, cigarette smoking, history of cardiovascular disease (coronary heart disease, congestive heart failure, peripheral vascular disease), atrial fibrillation, left ventricular hypertrophy, hyperhomocysteinemia, orthostatic hypotension, cardiac arrhythmias, hyperfibrinogenemia, and sleep apnea. Recently identified risk factors include chronic infection and elevation of C-reactive protein, particularly in patients with diabetes. Evidence from controlled clinical trials strongly suggests that control of vascular risk factors, in particular hypertension, could prevent the development of dementia.

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The Incidence of Vascular Dementia in Canada: A Comparison with Europe and East Asia

Cited by 78 publications

References 48 publications

Neuropsychological Performance Is Associated With Vascular Function in Patients With Atherosclerotic Vascular Disease

Neuropsychological Performance Is Associated With Vascular Function in Patients With Atherosclerotic Vascular Disease

Identifying and Characterizing Trajectories of Cognitive Change in Older Persons with Mild Cognitive Impairment

Vascular Dementia Prevention: A Risk Factor Analysis

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