The incidence patterns of Down syndrome in Qatar

Wahab, Atqah Abdul; Bener, Abdülbari; Teebi, Ahmad S.

doi:10.1111/j.1399-0004.2006.00593.x

Cited by 35 publications

(26 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high frequency and severity of CHD among Down syndrome children who are the offspring of consanguineous matting were reported in certain populations like Oman (Venugopalan and Agarwal, 2003), Turkey (Aynaci et al, 1998), india (Ashraf et al, 2010 and Qatar (Wahab et al, 2006). Al-Jarallah (2009) reported that the frequency of CHD was slightly higher in Down syndrome children of consanguineous parents from Riyadh population.…”

Section: Discussionmentioning

confidence: 99%

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

El-Attar¹

2014

Research J. of Cardiology

View full text Add to dashboard Cite

Congenital Heart Diseases (CHDs) occur in about 40-50% of neonates born with Down syndrome. Increased incidence of CHDs in children with Down syndrome in certain populations has been associated with widespread consanguinity. Up till now there is no explanation for why some Down syndrome patients are susceptible to CHDs. This study aims to evaluate the frequency and patterns of CHDs in Down syndrome children at Almadina province in the west of Saudi Arabia and compare it with other previously reported studies. The study included Down syndrome children referred to the pediatric cardiology clinic for screening of CHDs. Full history taking, pedigree analysis and clinical examination were done to all cases. Parental consanguinity was documented and echocardiography was done to assess the cardiac lesions. Out of 110 Down syndrome children, 45 (40.9%) had CHDs were selected. Parental consanguinity was present in 26/45 (57.8%). The most frequent lesion was AVSD (33.3%), followed by VSD (22.2%), then ASD (13.3%), PDA was present in 8.8% and TOF was diagnosed in one case. The most common combination of cardiac lesions in Down syndrome cases included in this study was ASD with VSD. Conclusion: The frequency of CHDs in Down syndrome children from Almadina province in the west of Saudi Arabia was similar to those reported worldwide. The most frequent lesion diagnosed in this study was AVSD. The CHDs were slightly more frequent in Down syndrome children born to consanguineous parents.

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

El-Attar¹

2014

Research J. of Cardiology

View full text Add to dashboard Cite

show abstract

“…The role of consanguinity in congenital malformations like DS and CHD has been studied by several authors from high consanguinity rate countries [12], [13], [14].…”

Section: Discussionmentioning

confidence: 99%

Consanguinity and pattern of congenital heart defects in Down syndrome in Kashmir, India

Ashraf¹,

Malla²

2010

AJSIR

View full text Add to dashboard Cite

show abstract

“…The incidence of 3.13/1,000 observed in the UAE population in Dubai is higher than most of the other Arab populations except for Kuwait, where it is reported to be between 2.9 and 3.50/1,000 [9,10] . The mean maternal age (33.48 8 8.08 years, range 17-54 years) in UAE nationals was lower compared to Egypt (38.2 years) and Qatar (35.4 8 6.5 years, range 21-51), but was slightly higher than that of Lebanon (32.19 years) [17][18][19] . The number of mothers in the advanced maternal age group ( 1 35 years) as seen in our study (41.66%) is similar to Lebanon (41.5%), but is less than that reported in Qatar (48.5%).…”

Section: Discussionmentioning

confidence: 99%

Incidence of Down Syndrome in Dubai, UAE

et al. 2006

View full text Add to dashboard Cite

Objective: To describe incidence of Down syndrome in Dubai, United Arab Emirates (UAE). Subjects and Methods: A total of 63,398 newborn babies in Dubai (24,250 UAE nationals and 39,148 non-UAE) during a 5-year period of 1999–2003 were routinely examined by experienced nurses, neonatologists, pediatricians and/or general practitioners for symptoms of Down syndrome. Those suspected with Down syndrome were referred to the cytogenetic laboratory for karyotyping. Results: A total of 141 cases were confirmed cytogenetically as Down syndrome. Of these, 139 were trisomy 21 and of the remaining 2, 1 was a translocation and the other a mosaic. Theoverall incidence of Down syndrome in Dubai was 1/449 live births (2.2 per 1,000); 1/319 live births (3.13 per 1,000) among UAE nationals and 1/602 live births (1.66 per 1,000) among non-UAE nationals. The mean maternal age of UAE national mothers was 33.48 ± 8.08, with 41.66% of the mothers being in the advanced maternal age group (>35 years). The higher incidence of Down syndrome among UAE nationals is comparable to incidences reported for other Arab populations in the Middle Eastern region. Advanced maternal age, with mothers bearing children until their 50s and higher parity, appear to be the major contributing factors for the increased incidence. Conclusion: The study indicates the need to provide efficient genetic counseling and to introduce an effective antenatal screening program and prenatal diagnostic services to reduce the psychological and genetic burden on the families and community.

show abstract

The incidence patterns of Down syndrome in Qatar

Cited by 35 publications

References 18 publications

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

Congenital Heart Diseases in Saudi Down Syndrome Children: Frequency and Patterns in Almadinah Region

Consanguinity and pattern of congenital heart defects in Down syndrome in Kashmir, India

Incidence of Down Syndrome in Dubai, UAE

Contact Info

Product

Resources

About