The Incidence Rate of Thyroid Cancer Among Women in Saudi Arabia: An Observational Descriptive Epidemiological Analysis of Data from Saudi Cancer Registry 2001–2008

Alghamdi, Ibrahim G; Hussain, Issam; Alghamdi, Mohamed S.; Dohal, Ahlam A.; Almalki, Shaia Saleh R.; El-Sheemy, Mohammed A

doi:10.1007/s10903-014-0044-5

Cited by 14 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incidence rates vary according to age, sex, geographic populations, and ethnic groups. 1 The worldwide incidence rate for thyroid cancer falls within a wide range, according to the International Agency for Research on Cancer (IARC). Regions with the highest thyroid cancer rate include the Pacific Islands (Hawaii), Central America, Japan, East Asia (Korea, Hong Kong), Kuwait, and Iceland.…”

Section: Introductionmentioning

confidence: 99%

Trends in thyroid carcinoma among thyroidectomy patients: a 12-year multicenter study

et al. 2019

View full text Add to dashboard Cite

BACKGROUND: Thyroid malignancy, the most diagnosed cancer of the endocrine system, represents 2% of all malignancies worldwide. The increasing incidence of thyroid cancer has been linked to the increasing sensitivity of modern diagnostic methods which overdiagnosis small thyroid tumors.OBJECTIVES: Assess the distribution and trends in thyroid cancer among thyroidectomy patients.DESIGN: Descriptive, based on medical record review.SETTINGS: Two tertiary care centers in Riyadh.PATIENTS AND METHODS: We included patients who underwent thyroid surgery from January 1, 2004 to December 31, 2016 who ranged in age from 9–90 years regardless of initial diagnosis.MAIN OUTCOME MEASURES: Distribution of thyroid carcinomas by type, age and sex and trends over the time period.SAMPLE SIZE: 979 patients.RESULTS: Of 979 patients, 84.5% were <55 years old, with the majority being female. Thyroid malignancy ranked second to benign tumors, and the most common type of thyroid cancer was papillary thyroid carcinoma (91% of malignant tumors), followed by follicular thyroid cancer (4.7% of malignant tumors). After thyroid microcarcinomas were isolated from the sample and studied separately, we found the overall trend for thyroid cancer to be stable, and that the annual increases in rates were due to increased diagnosis of thyroid microcarcinoma in the period from 2010 to 2016.CONCLUSION: Our study shows that increases in thyroid cancers may be attributed to a rise in the rates of diagnosis of thyroid microcarcinomas.LIMITATIONS: The main limitation is the retrospective nature of this design. Also, a multicenter collaboration would prove beneficial in evaluating the trends of thyroid cancer in Saudi Arabia on a much larger scale.CONFLICT OF INTEREST: None.

show abstract

Section: Introductionmentioning

confidence: 99%

Trends in thyroid carcinoma among thyroidectomy patients: a 12-year multicenter study

et al. 2019

View full text Add to dashboard Cite

show abstract

“… 16 However, compared with the developed countries, studies on the prevalence, incidence, and type of thyroid cancer in Saudi Arabia continue to be inadequate because of the absence of pertinent studies performed in these specific areas. 17 Hence, this study aimed to determine the risk of malignancy in TN, employing nodule size, TSH level, as well as the Bethesda system, which enhances the evaluations of the findings from FNA cytology (FNAC) and the TI-RADS, and in turn, the analysis of the US reports among the surgically excised nodules.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Nodule Management: Thyroid-Stimulating Hormone, Ultrasound, and Cytological Classification System for Predicting Malignancy

et al. 2018

View full text Add to dashboard Cite

Background/objectives:Thyroid nodule (TN) is a common thyroid disorder globally, and the incidence has been increasing in recent decades. The objective of this study was to determine the contribution of thyroid-stimulating hormone (TSH), ultrasound (US), and cytological classification system for predicting malignancy among the surgically excised nodules.Design and methods:A retrospective analysis was performed between January 2012 and December 2014, using data drawn from 1188 patients (15-90 years), who had 1433 TN and fine-needle aspiration in Prince Sultan Military Medical City, Saudi Arabia. After reviewing all the thyroid cytopathological slides and US reports, classification was done based on the Bethesda System for Reporting Thyroid Cytology and the Thyroid Imaging Reporting and Data System (TI-RADS).Results:A total of 1188 patients’ medical records were reviewed for this study, among them 311 patients had undergone surgical intervention (253 patients had single nodule and 58 had 2 nodules), with a total of 369 nodules. However, as 54 nodules on the US were either unavailable or unclear, the 315 remaining nodules were analyzed, revealing 30.2% (n = 95) malignancy overall. Patients with TSH values of >4.5 mIU/L (38.2%), TN <1 cm (48.8%), TI-RADS category 5 (75.6%), and Bethesda category VI (88.9%) revealed a higher percentage of malignancy. From the univariate analysis using the χ2 test, significant relationship between the TSH, nodule size, TI-RADS, and the Bethesda category between the malignant and benign nodules emerged. The regression analysis showed that patients with a TSH value of 0.5 to 4.5 mIU/L (odds ratio [OR]: 2.96), TSH >4.5 mIU/L (OR: 6.54) had higher risk for malignancy than those with a TSH value of ≤0.4 mIU/L. Thyroid nodules with sizes of 1 to 1.9 cm (OR: 1.12), 2 to 2.9 cm (OR: 0.74), 3-3.9 cm (OR: 1.21), and ≥4 cm (OR: 0.52) were found to have no association with the risk of malignancy. Compared with TI-RADS 2 patients, those with categories 4B (OR: 1.35) and 5 (OR: 2.3) were found to be at higher risk of malignancy. Similarly, Bethesda IV (OR: 2.72), V (OR: 8.47), and VI (OR: 20; P < .02) category patients had a higher risk for malignancy than those in Bethesda class I. Among the study population, the papillary thyroid carcinoma was the most common type of thyroid cancer (86, 90.5%) followed by 7.4% (n = 7) of follicular thyroid carcinoma, 1.05% (n = 1) of anaplastic carcinoma, and 1.05% (n = 1) of medullary thyroid carcinoma.Conclusions:A predictive model for risk of malignancy using a combining characteristic of the TSH, US, and cytological classification systems could assist the clinicians in minimizing exposing the patients with TNs to nonessential invasive procedures.

show abstract

“…The last decades have revealed a constant and remarkable rise in the occurrence of thyroid cancer across the world, including Saudi Arabia[3-5]. The Saudi Cancer Registry (SCR) report has registered 890 thyroid cancer cases, in nearly 8.1% of all the newly diagnosed cases in 2012.…”

Section: Introductionmentioning

confidence: 99%

Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia

Dawish¹,

Robert²,

Muna³

et al. 2017

WJCO

View full text Add to dashboard Cite

AIMTo stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system.METHODSFrom January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients (15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. All thyroid cyto-pathological slides and ultra sound reports were reviewed and classified according to the Bethesda System for Reporting Thyroid Cytopathology. Age, gender, cytological features and histological types of the thyroid cancer were collected from patients’ medical chart and cytopathology reports.RESULTSThere were 124 total cases of malignancy on resection, giving an overall surgical yield malignancy of 33.6%. Majority of the thyroid cancer nodules (n = 57, 46%) in Bethesda VI category followed by Bethesda IV (n = 25, 20.2%). Almost 40% of the cancer nodules in 31-45 age group in both sex. Papillary thyroid carcinoma (PTC) was the most common form of thyroid cancer among the study population (111, 89.6%) followed by 8.9% of follicular thyroid carcinoma (FTC), 0.8% of medullary carcinoma and 0.8% of anaplastic carcinoma. Among the Bethesda IV category 68% thyroid nodules were PTC and 32% FTC.CONCLUSIONThe malignancy values reported in our research were constant and comparable with the results of other published data with respect to the risk of malignancy. Patients with follicular neoplasm/suspicious for follicular neoplasm and suspicious of malignancy categories, total thyroidectomy is indicted because of the substantial risk of malignancy.

show abstract

The Incidence Rate of Thyroid Cancer Among Women in Saudi Arabia: An Observational Descriptive Epidemiological Analysis of Data from Saudi Cancer Registry 2001–2008

Cited by 14 publications

References 3 publications

Trends in thyroid carcinoma among thyroidectomy patients: a 12-year multicenter study

Trends in thyroid carcinoma among thyroidectomy patients: a 12-year multicenter study

Thyroid Nodule Management: Thyroid-Stimulating Hormone, Ultrasound, and Cytological Classification System for Predicting Malignancy

Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia

Contact Info

Product

Resources

About