The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-β-cyclodextrin

Tommasini, S.; Calabrò, Marco; Stancanelli, Rosanna; Donato, Paola; Costa, Chiara; Catania, Stefania; Villari, Valentina; Ficarra, P.; Ficarra, R.

doi:10.1016/j.jpba.2005.05.009

Cited by 78 publications

(51 citation statements)

References 31 publications

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“…The inclusion of hesperetin and hesperidin in (2-hydroxypropyl)-b-cyclodextrin (HP-b-CD) [159]; quercetin and myricetin in HP-b-CD, maltosyl-b-CDs, and b-CDs [160]; kaempferol, quercetin, and myricetin in HP-b-CD [161]; 3-hydroxyflavone (3-OHeF), morin, and quercetin in a-and b-CDs [162]; and rutin in b-CD [163] have been studied, and their water solubility improved by encapsulation. In addition, their antioxidant activities were shown to be increased in these CD-encapsulated systems.…”

Section: Inclusion Encapsulation-cyclodextrinsmentioning

confidence: 99%

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Verri

Vicentini

Baracat

et al. 2012

Studies in Natural Products Chemistry

117

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Section: Inclusion Encapsulation-cyclodextrinsmentioning

confidence: 99%

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Verri

Vicentini

Baracat

et al. 2012

Studies in Natural Products Chemistry

117

View full text Add to dashboard Cite

“…There have been a number of recent reviews focusing on the encapsulation of the more widely used polyphenols, discussing their effectiveness, variations, developments and trends (Barras et al, 2009;Das, Ng, 2010;Di Mattia et al, 2009;Dube et al, 2010;Ersus, Yurdagel, 2007;Fang et al, 2006;Hu et al, 2008;Kosaraju, Dath, Lawrence, 2006;Laine et al, 2008;Liang et al, 2011;Lucas-Abellan et al, 2007;Mourtzinos et al, 2007;Shi et al, 2007;Shutava et al, 2009;Tommasini et al, 2005;Zhang, Mou, Du, 2007;Xiong et al, 2006;Yu, Huang, 2010).…”

Section: Introductionmentioning

confidence: 99%

Alginate-pomegranate peels' polyphenols beads: effects of formulation parameters on loading efficiency

Zam

Bashour

Abdelwahed

et al. 2014

Braz. J. Pharm. Sci.

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Calcium alginate beads containing pomegranate peels' polyphenol extract were encapsulated by ionic gelation method. The effects of various formulation factors (sodium alginate concentration, calcium chloride concentration, calcium chloride exposure time, gelling bath time maintaining, and extract concentration) on the efficiency of extract loading were investigated. The formulation containing an extract of 1 g pomegranate peels in 100 mL distilled water encapsulated with 3 % of sodium alginate cured in 0.05 M calcium chloride for 20 minutes and kept in a gelling bath for 15 minutes was chosen as the best formula regarding the loading efficiency. These optimized conditions allowed the encapsulation of 43.90% of total extracted polyphenols and 46.34 % of total extracted proanthocyanidins. Microencapsulation of pomegranate peels' extract in calcium alginate beads is a promising technique for pharmaceutical and food supplementation with natural antioxidants.

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“…We used an ex vivo human skin model to investigate the protective activity of the flavonoid hesperetin against BaP-induced toxicity. This study was aimed to evaluate the biological activity of the hesperetin complex obtained by inclusion complex formation with β-cyclodextrin, which increased its antioxidant properties (Tommasini et al 2005). Data obtained have demonstrated as a short time treatment of human skin tissue with HE/HP-β-CyD complex significantly reduces oxidative stress conditions resulting by BaP exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Inclusion complex with 1:1 HE/HP-β-CyD molar ratio was prepared by co-evaporation method (Tommasini et al 2005) by shaking the appropriate amounts of drug and macrocycle in water. Briefly, the mixture was stirred for 1 h, under controlled temperature (25.0± 0.01°C).…”

Section: Preparation Of An Inclusion Complex Of Hesperetinmentioning

confidence: 99%

Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin

et al. 2011

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Skin cancer pathogenesis is partially associated to the oxidative stress conditions induced by environmentally carcinogens such as benzo[a]pyrene (BaP). The protective effects against BaP-induced oxidative stress of the flavonoid hesperetin as a complex with the 2-hydroxypropyl-β-cyclodextrin (HE/HP-β-CyD) have been evaluated using an ex vivo human skin model. Human healthy skin has been pre-treated with the functionalized complex HE/HP-β-CyD (0.5-50 μM) before BaP (5 μM) application simulating occupational and environmental exposure. Oxidative stress was evaluated in terms of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide reduction, protein peroxidation and reactive oxygen species (ROS) formation. Additionally, it has been investigated whether the potential protective effects of HE/HP-β-CyD may be correlated to the interaction with aryl hydrocarbon receptor (AhR) pathway. A significant protection by HE/HP-β-CyD against the BaP-induced increase in ROS and carbonyl compound production, as well as reduction in tissue viability, has been observed (p<0.001). Results obtained showed that HE/HP-β-CyD was also able to reduce BaP-induced AhR and CYP1A1 protein expression (p<0.001). Experimental evidences provided from this study suggest significant preventive properties of HE/HP-β-CyD in the toxicity caused by environmental carcinogens such as PAHs.

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The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-β-cyclodextrin

Cited by 78 publications

References 31 publications

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Alginate-pomegranate peels' polyphenols beads: effects of formulation parameters on loading efficiency

Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin

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