In this paper, we investigate the global existence and uniqueness of strong solutions to 2D incompressible inhomogeneous Navier-Stokes equations with viscous coefficient depending on the density and with initial density being discontinuous across some smooth interface. Compared with the previous results for the inhomogeneous Navier-Stokes equations with constant viscosity, the main difficulty here lies in the fact that the L 1 in time Lipschitz estimate of the velocity field can not be obtained by energy method (see [11,20,21] for instance). Motivated by the key idea of Chemin to solve 2-D vortex patch of ideal fluid ([6, 7]), namely, striated regularity can help to get the L ∞ boundedness of the double Riesz transform, we derive the a priori L 1 in time Lipschitz estimate of the velocity field under the assumption that the viscous coefficient is close enough to a positive constant in the bounded function space. As an application, we shall prove the propagation of H 3 regularity of the interface between fluids with different densities.