The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers

Li, Qingning; Wang, Xuemei; Lü, Xiaohua; Tian, Haijun; Jiang, Hui; Liu, Gang; Guo, Dadong; Wu, Chunhui; Chen, Baoan

doi:10.1016/j.biomaterials.2009.05.015

Cited by 115 publications

(64 citation statements)

References 24 publications

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“…Because DNR has nice fluorescence emission spectra with the wavelength ranging from 530 to 640 nm when excited at 488 nm, the inverted fluorescence microscope of the intracellular fluorescence of DNR could be readily observed after DNR was cultured with cells, while more and more brightening cell images can be observed with the culture time lengthened, as shown in Figure 4. These images and all the changing processes indicate the dynamic drug absorbing process of cancer cells, where DNR can act not only as the anticancer drug but also as a good probe for relevant biomedical detection [19]. It is evident that the intracellular fluorescence intensity of DNR is proportional to the intracellular drug concentration.…”

Section: Real-time Detection Of Dnr Residues When Treated With K562 Cmentioning

confidence: 98%

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

Zhao

et al. 2010

Sci. China Chem.

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In this study, we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore, this new nano-interface and Au-MCNT modified electrode could be explored as a rapid, highly sensitive, and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications. pharmaceutical analysis, electrochemical detection, anticancer drugs, gold nanoparticles, multi-walled carbon nanotubes

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Section: Real-time Detection Of Dnr Residues When Treated With K562 Cmentioning

confidence: 98%

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

Zhao

et al. 2010

Sci. China Chem.

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“…However, X-rays can also be used to generate the same effect. Loose TNT-like fragments/TiO 2 whiskers (with three-dimensional mesoporous structure) have also been demonstrated as nano-vehicles for carrying active anti-cancer drug daunorubicin (DNR) for anti-tumor functions [153]. Studies with the human hepatocarcinoma [149], and c concept for applying TNTs on Ti wires as tiny implants for brain therapy [57].…”

Section: Anti-cancer Therapymentioning

confidence: 99%

Titania Nanotubes for Local Drug Delivery from Implant Surfaces

Gulati

Kogawa

Maher

et al. 2015

Electrochemically Engineered Nanoporous Materials

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The principal challenge for bone therapy is to deliver an effective dose of therapeutic agent (for example antibiotic or anti-cancer drug) to the affected site within bone, while sparing other organs. The solution to this dilemma is to deliver drug locally within the bone; hence various surface/therapeutic modifications of the conventional bone implants have been suggested to achieve this. Implants composed of biocompatible materials and loaded with active therapeutics thus provide one possible option for effective bone therapy. This chapter showcases the challenges that an electrochemically nano-engineered bone implant based on titania nanotubes must overcome to survive and deliver therapeutics in conditions such as infections and cancer of bone. The fabrication of titania nanotubes, the therapeutic loading and release, ex vivo and in vivo investigations; all are reviewed in terms of effectiveness for therapeutic action. Also discussed are the potential advances of titania nanotube technology and the future research directions to address additional clinical problems.

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“…7 In view of these developments, the aim of this paper was to explore a novel "smart" pH-responsive DDS based on titanium dioxide (TiO 2 ) nanoparticles that is chemically stable, environmentally friendly, and noncytotoxic. 8,9 This DDS could provide a simple and easy way to enable intelligently controlled release of DNR and enhance its chemotherapeutic efficiency. To the best of the authors' knowledge, no study has been carried out on TiO 2 nanoparticles for "smart" stimulisensitive DDS and is investigated here for the first time.…”

Section: Introductionmentioning

confidence: 99%

Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system

Zhang

Wang²,

Chen³

et al. 2012

IJN

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Daunorubicin (DNR) has a broad spectrum of anticancer activity, but is limited in clinical application due to its serious side effects. The aim of this study was to explore a novel "smart" pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO 2 ) nanoparticles for its potential in enabling more intelligent controlled release and enhancing chemotherapeutic efficiency of DNR. DNR was loaded onto TiO 2 nanoparticles by forming complexes with transition metal titanium to construct DNR-TiO 2 nanocomposites as a DDS. DNR was released from the DDS much more rapidly at pH 5.0 and 6.0 than at pH 7.4, which is a desirable characteristic for tumor-targeted drug delivery. DNR-TiO 2 nanocomposites induced remarkable improvement in anticancer activity, as demonstrated by flow cytometry, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and nuclear 4′,6-diamidino-2-phenylindole staining. Furthermore, the possible signaling pathway was explored by western blot. For instance, in human leukemia K562 cells, it was demonstrated that DNR-TiO 2 nanocomposites increase intracellular concentration of DNR and enhance its anticancer efficiency by inducing apoptosis in a caspase-dependent manner, indicating that DNR-TiO 2 nanocomposites could act as an efficient DDS importing DNR into target cancer cells. These findings suggest that "smart" DNR delivery strategy is a promising approach to cancer therapy.

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The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers

Cited by 115 publications

References 24 publications

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

Titania Nanotubes for Local Drug Delivery from Implant Surfaces

Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system

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The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers

Cited by 115 publications

References 24 publications

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

Titania Nanotubes for Local Drug Delivery from Implant Surfaces

Daunorubicin-TiO2 nanocomposites as a &ldquo;smart&rdquo; pH-responsive drug delivery system

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Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system