The increase of Hodgkin's disease incidence among young adults

Chen, Ya-Ting; Zheng, Tongzhang; Chou, Mei-Chu; Boyle, Peter; Holford, Theodore R.

doi:10.1002/(sici)1097-0142(19970601)79:11<2209::aid-cncr20>3.0.co;2-z

Cited by 37 publications

(35 citation statements)

References 23 publications

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“…64 We confirm the continued stability of lymphoblastic leukemia/lymphoma and Burkitt lymphoma/leukemia rates in United States children 65 and a continuation of the decades-long decline in classical Hodgkin lymphoma, particularly in the mixed cellularity/lymphocytedepleted subtype, though the causes of this decline remain unknown. 33,34,65 During 1992-2001, lymphoid neoplasms accounted for approximately one third of all cancers diagnosed in children in the United States 42 ; thus, understanding the effects of perinatal and early life exposures in the etiology of these neoplasms may be important.…”

Section: Incidence Patterns Of Lymphoid Neoplasmsmentioning

confidence: 89%

“…Other reports on incidence patterns of individual subtypes during the last 15 years also suggest that patterns vary among the lymphoid neoplasms. [11][12][13]15,17,[30][31][32][33][34][35][36][37][38][39] To date, no systematic descriptive analysis has considered incidence patterns for the entirety of lymphoid neoplasm subtypes as defined by the WHO classification. 28 Because the causes of most lymphoid neoplasms remain largely unknown, comparison of incidence rates and patterns for specific subtypes may provide critical clues for future etiologic investigations.…”

Section: Introductionmentioning

confidence: 99%

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Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001

Morton

Wang

Devesa

et al. 2006

Blood

1,502

1,117

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Age-specific and age-adjusted rates were compared by sex and race (white, black, Asian). Age-adjusted trends in incidence were estimated by sex and race using weighted least squares log-linear regression. Diverse incidence patterns and trends were observed by lymphoid neoplasm subtype and population. In the elderly (75 years or older), rates of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma increased 1.4% and 1.8% per year, respectively, whereas rates of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) declined 2.1% per year. Although whites bear the highest incidence burden for most lymphoid neoplasm subtypes, most notably for hairy cell leukemia and follicular lymphoma, black predominance was observed for plasma cell and T-cell neoplasms. Asians have considerably lower rates than whites and blacks for CLL/SLL and Hodgkin lymphoma. We conclude that the striking differences in incidence patterns by histologic subtype strongly suggest that there is etiologic heterogeneity among lymphoid neoplasms and support the pursuit of epidemiologic analysis by subtype. (Blood. 2006;107:265-276)

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Section: Incidence Patterns Of Lymphoid Neoplasmsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001

Morton

Wang

Devesa

et al. 2006

Blood

1,502

1,117

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“…9 In the 20 years after the mid-1970s, the incidence of young-adult HD rose in the US, particularly in women. 10,11 Between 1975-79 and 1990 -94, 5-year average annual rates for white women aged 20 -24 increased 35%, from 4.6 to 6.2 per 100,000. 12 This period followed decades of demographic change in the US, with increases in socioeconomic affluence, reductions in average family size and improvement in women's educational status, among other shifts.…”

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confidence: 99%

Social class and risk of Hodgkin's disease in young‐adult women in 1988–94

Glaser

Clarke

Nugent

et al. 2001

Intl Journal of Cancer

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Hodgkin's disease (HD) risk in young adults has been associated with higher childhood social class. Although recent decades have witnessed increases in both young-adult HD incidence rates and the socioeconomic affluence reported to influence risk, social class risk factors have not been reexamined. For 204 cases and 254 controls aged 19 -44 years from a population-based case-control study of HD diagnosed in 1988 -94 in San Francisco area females, we evaluated social class predictors of HD overall and for subgroups defined by age and by ethnicity. HD was associated weakly with a few childhood social class markers but more strongly with combinations of these variables. Risk was higher for women with family-owned than rented childhood homes; for US-born women with single vs. shared bedrooms at age 11; and for women with 2؉ births who were from smaller than larger childhood households. These patterns differed by age, with risk appearing to increase over the young-adult years for some factors and to decrease for others. In whites, risk was additionally associated with having a single childhood bedroom in larger households, and with tall adult height in women from smaller childhood households. In nonwhites, risk was higher for single bedrooms at age 11 in smaller childhood households, taller height and higher maternal education. Most study findings support the hypothesis that HD development in young adults follows protection from early exposure to other children. Variation in risk by age suggests differing etiologies across young adulthood, or the importance of birth cohort-appropriate social-class measures. Negative findings for previously reported risk factors may reflect their insufficient heterogeneity of exposure or their failure to measure cohort-relevant exposures in this population. © 2002 Wiley-Liss, Inc. Key words: Hodgkin's disease; social class; women; epidemiology; risk factorsIn the 1960s and 1970s, observations that social class indicators were associated with Hodgkin's disease (HD) provided support for MacMahon's hypothesis that infectious agents were involved in the etiology of this lymphoma in young adults. [1][2][3][4][5][6][7] In a Boston population in the mid 1970s, Gutensohn and Cole 8 found that HD risk in young adults was linked to small sibships, early birth order, single-family housing, few playmates and higher maternal education in childhood. Collectively, these childhood social class factors described diminished contact with children and thus suggested that HD etiology involves delay in exposure to common childhood infections until older childhood or adolescence, when such illnesses may be more virulent. This interpretation has been supported by the association of HD with a history of infectious mononucleosis (IM), a clinical manifestation of late-onset primary infection with Epstein-Barr virus (EBV). 9 In the 20 years after the mid-1970s, the incidence of young-adult HD rose in the US, particularly in women. 10,11 Between 1975-79 and 1990 -94, 5-year average annual rates for white women a...

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“…In addition, one should be reserved when comparing Israel to Germany regarding measles. In Israel, the population has been subject to frequent outbursts of measles and it has shown a steady increase in the incidence of young adult cHL [40][41][42].…”

Section: Our Reservations Regarding the German Experimentsmentioning

confidence: 99%

Relevance of the Measles Virus Expression in Cancer - an Update

Benharroch

Ariad

Tadmor

et al. 2016

Pathol. Oncol. Res.

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Evidence of an association between classical Hodgkin lymphoma and the measles virus has previously been presented by our group. Arguments held against our thesis were reevaluated. Substantiation of a relationship between the measles virus and additional solid tumors was submitted. Moreover, a pathogenic pathway was suggested to support a possible contribution of the measles virus to the development of classical Hodgkin lymphoma. We have chosen to exclude a discussion of measles virotherapy, since this carries distinct implications. We now add new evidence regarding the expression of the measles virus phosphoprotein in a few cancers. We also suggest a role in this context for atypical measles syndrome in malignant tumors. Last, we propose a collaboration which may make the best, on the one hand of our cohort of classical Hodgkin lymphoma, half of which carry the measles virus expression in their tumor cells. The planned study will also look into the patients vaccination records and into a previous history of the measles disease. On the other hand, cohorts of patients diagnosed with late onset measles will be assessed for the eventual diagnosis of atypical measles syndrome and will be followed up for the subsequent development of a malignant tumor.

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The increase of Hodgkin's disease incidence among young adults

Cited by 37 publications

References 23 publications

Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001

Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001

Social class and risk of Hodgkin's disease in young‐adult women in 1988–94

Relevance of the Measles Virus Expression in Cancer - an Update

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