The increased echogenicity of the pancreas in infants and children: the white pancreas

Schneider, K.; Harms, Karsten; Fendel, H

doi:10.1007/bf00441605

Cited by 16 publications

(8 citation statements)

References 11 publications

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“…The typical fine-lobular (cobblestonelike) normal echo pattern of the pancreas is often no longer detectable in patients with CF. Lipomatosis and fibrosis are considered characteristic findings in children with CF, [6][7][8][9] which is in accordance with our results in adults. Detectable sonographic changes of the pancreatic duct in patients with CF are rare and stand in contrast to the findings in chronic pancreatitis in adults.…”

Section: Sonographic Findings In Adult Patients With Cystic Fibrosissupporting

confidence: 92%

Sonographic Findings of the Hepatobiliary‐Pancreatic System in Adult Patients With Cystic Fibrosis

Dietrich

Chichakli

Hirche

et al. 2002

J of Ultrasound Medicine

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Section: Sonographic Findings In Adult Patients With Cystic Fibrosissupporting

confidence: 92%

Sonographic Findings of the Hepatobiliary‐Pancreatic System in Adult Patients With Cystic Fibrosis

Dietrich

Chichakli

Hirche

et al. 2002

J of Ultrasound Medicine

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“…Increased pancreatic echogenicity in SBDS patients was first reported 20 years ago [11,12]. This finding is consistent with pathological findings of fatty infiltration of the pancreas with a reduction in acini and conservation of islets [4].…”

Section: Discussionsupporting

confidence: 87%

Usefulness of pancreatic ultrasonography in the diagnosis of Shwachman‐Bodian‐Diamond syndrome

Adachi¹,

Tachibana²,

Asakura³

et al. 2005

Acta Paediatrica

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“…In contrast, we do not observe the above finding in normal children 4 . The presence of fibrous tissue or fat infiltration 6 may be responsible for increased echogenicity of the gland, such as in chronic pancreatitis 7 , cystic fibrosis 8 and Schwachman's syndrome 8 . Systematic transfusions to patients with ß-thalassemia cause hemosiderosis of the pancreas, resulting in secondary fibrosis and increase of echogenicity 1 .…”

Section: Discussionmentioning

confidence: 99%

Ultrasonography of the Pancreas, as a Function Index, in Children with β-Thalassemia

Theochari¹,

Ioannidou²,

H³

et al. 2000

Journal of Pediatric Endocrinology and Metabolism

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Increased echogenicity of the pancreas, due to hemosiderosis, is a frequent laboratory finding in children and adolescents with beta-thalassemia. The aim of this study was to investigate whether increased echogenicity of the pancreas is associated with dysfunction. The ultrasonic image of the pancreas was examined in 34 children aged 12+/-3.8 years old and was compared to the endocrine and exocrine functioning of the gland. Oral glucose tolerance test (OGTT) was performed with simultaneous measurement of insulin and serum trypsin. Twenty-six of the 34 patients (76.5%) presented increased echogenicity, while 8 (23.5%) had a normal ultrasonic pancreatic image. 77% of the patients with increased echogenicity had abnormal OGTT, 46%, with subnormal or increased insulin values, and 32.5% manifested low levels of trypsin. Among the patients with normal ultrasound, 25% had abnormal OGTT and 37.5% abnormal insulin values. Statistical analysis with Student's t-test revealed that patients with increased echogenicity had significantly higher glucose values on OGTT at 60: 7.6 +/- 1.8 mmol/l (137.3 +/- 33.7 mg/dl) as compared to the patients with normal ultrasound: 6.1 +/- 1.2 mmol/l (110.75 +/- 21.72 mg/dl) (p<0.05). Insulin values were significantly affected at 30, 60, and 90 min: 570+/-301, 332+/-156, 294+/-158 pmol/l (79.54 +/- 42, 46.4 +/- 21.8, 41.04 +/- 22 mU/l) respectively in patients with increased echogenicity in comparison to those with normal ultrasonographic image of the gland: 301 +/- 170, 192 +/- 52, 135 +/- 63 pmol/l (42 +/- 23.7, 26.85 +/- 7.36, 18.9 +/- 8.8 mU/l) (p<0.05). No statistical significance was observed between the two groups regarding trypsin levels, even though abnormal values were observed in more children with increased echogenicity than in patients with a normal ultrasound. The above findings confirm that increased echogenicity of the pancreas is associated with disturbance of its function. This simple imaging method could be used as a rough early index of detection of an increased risk for developing diabetes mellitus in patients with beta-thalassemia.

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The increased echogenicity of the pancreas in infants and children: the white pancreas

Cited by 16 publications

References 11 publications

Sonographic Findings of the Hepatobiliary‐Pancreatic System in Adult Patients With Cystic Fibrosis

Sonographic Findings of the Hepatobiliary‐Pancreatic System in Adult Patients With Cystic Fibrosis

Usefulness of pancreatic ultrasonography in the diagnosis of Shwachman‐Bodian‐Diamond syndrome

Ultrasonography of the Pancreas, as a Function Index, in Children with β-Thalassemia

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