The Increased Risk of Death from Ischaemic Heart Disease in First Degree Relatives of 121 Men and 96 Women with Ischaemic Heart Disease

Abstract

The risks of death from ischaemic heart disease, cerebral haemorrhage, and thrombosis, and the risks of death from all causes have been estimated among the first degree relatives of male and female index patients with ischaemic heart disease. These

Identifying genes for coronary artery disease: An idea whose time has come

“…In families with CAD onset before age 46, heritability was estimated to be 92% to 100%, whereas in families of older cases, the heritability ranged from 15% to 30% (41). It is also of note that the risk of disease is typically several times greater in relatives of female cases than in relatives of male cases (40,41). Premature CAD in the young reflects a multi-hit genetic inheritance, and these individuals transmit an even greater genetic load to their offspring (43).…”

“…The extent of coronary occlusion in patients with CAD also relates to a parental history of myocardial infarction (42). The earlier the age of onset of CAD in a particular individual, the greater the risk of relatives developing CAD (40). In families with CAD onset before age 46, heritability was estimated to be 92% to 100%, whereas in families of older cases, the heritability ranged from 15% to 30% (41).…”

Prediction of Coronary Heart Disease Risk in a South European Population: A Case-Control Study

“…Genetic factors also contribute significantly to most of the major risk factors for CHD [diabetes, hypertension, elevated plasma levels of lowdensity lipoprotein cholesterol (LDL-C) and low levels of plasma high-density lipoprotein cholesterol (HDL)], and yet the contribution of family history is not fully explained by known cardiac risk factors, suggesting that other yet-to-be-determined genetic factors also contribute to cardiovascular risk (Cohen, 2006;Slack et al,1966). …”

“…Furthermore, family history is a significant risk factor for atherosclerosis, and the contribution of family history cannot be fully accounted for by known cardiac risk factors (Colditz et al, 1986;Slack & Evans, 1966;Snowden et al, 1982). Genetic factors also contribute significantly to most of the major risk factors for CHD [diabetes, hypertension, elevated plasma levels of lowdensity lipoprotein cholesterol (LDL-C) and low levels of plasma high-density lipoprotein cholesterol (HDL)], and yet the contribution of family history is not fully explained by known cardiac risk factors, suggesting that other yet-to-be-determined genetic factors also contribute to cardiovascular risk (Cohen, 2006;Slack et al,1966).…”

Session 4: CVD, diabetes and cancer Evidence for the use of the Mediterranean diet in patients with CHD

“…The non-modifiable risk factors for CHD include genetic predisposition, gender and age (8,9) . However, the majority of risk factors that contribute to CHD risk, including dyslipidaemia, hypertension, smoking and diabetes, are modifiable (10) .…”