The increasing impact of a higher body mass index on the decrease in plasma B-type natriuretic peptide levels

Abstract

Background: Plasma B-type natriuretic peptide (BNP) levels are increased in patients with heart failure and are negatively correlated with body mass index (BMI). However, the effects of BMI in decreasing the plasma BNP levels have not been examined among patients in different BMI categories. Methods: 676 consecutive patients were divided into groups according to their BMI and heart failure grade. We examined the relationship between plasma BNP level and BMI in patients who were admitted to our cardiovascular unit. Results: There were significant differences, not only in the mean plasma BNP level, but also in the distribution pattern of the plasma BNP levels between the low-and high-BMI groups. The plasma BNP levels were negatively correlated with the BMI values in each group stratified by the New York Heart Association (NYHA) class (I, II and III + IV); however, the regression line was steeper for the higher NYHA classification, and the plasma BNP levels remained low in patients with a high BMI, even in the NYHA III + IV group. Conclusions: BMI is a significant factor that reduces the plasma BNP level. This impact is significantly increased in patients with a high BMI, even among those with a worsening severity of heart failure.

The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure

“…BMI might not be a suitable marker for an analysis of the diabetic condition. Even so, the previous reports using BMI as a potential index of obesity clearly showed a negative correlation between plasma BNP levels and obesity (43,44).…”

High Dose <i>β</i>-Blocker Therapy Triggers Additional Reverse Remodeling in Patients With Idiopathic Non-Ischemic Cardiomyopathy

“…For continuous variables, the mean and standard deviation are reported. With respect to BNP, logarithmic values of BNP, which were demonstrated to have a normal distribution, 17) were used for statistical analysis. First, the changes in EF, LVDd, LVDs, HR, SBP, BNP, and logarithmic values of BNP were simply analyzed according to each carvedilol dose using the paired t-test.…”

Potent influence of obesity on suppression of plasma B-type natriuretic peptide levels in patients with acute heart failure: An approach using covariance structure analysis

“…The tendency toward an inverse relationship between obesity and low plasma BNP levels was reported by Wang et al [13] and others [6,7,14]. We also investigated the degree of influence of obesity on plasma BNP levels, and examined the relationship between the BNP level and BMI in patients who were admitted to our cardiovascular unit [15]. The BMI was a significant factor reducing plasma BNP levels, and its impact significantly increased in relation to the BMI value.…”