The increasing potential of nuclear medicine imaging for the evaluation and reduction of normal tissue toxicity from radiation treatments

Mohan, Vineet; Bruin, N. M.W.J de; Kamer, Jeroen B. van de; Sonke, Jan‐Jakob; Vogel, Wouter V.

doi:10.1007/s00259-021-05284-5

“…However, external radiotherapy sends rays to the tumor site in the body from outside the body, which usually causes more side effects than internal radiotherapy [ 108 ]. These effects include nausea, vomiting, bone marrow suppression, liver function damage, and in extreme cases, gastrointestinal bleeding [ 109 ]. Internal radiotherapy for liver cancer is treated by direct intratumoral injection or transcatheter hepatic artery radioembolization [ 110 , 111 ].…”

Section: Function Of Hydrogelsmentioning

confidence: 99%

Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Xu,

Liu,

Liu

et al. 2024

J Nanobiotechnol

1

0

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Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide and is characterized by high rates of morbidity and mortality, posing a serious threat to human health. Interventional embolization therapy is the main treatment against middle- and late-stage liver cancer, but its efficacy is limited by the performance of embolism, hence the new embolic materials have provided hope to the inoperable patients. Especially, hydrogel materials with high embolization strength, appropriate viscosity, reliable security and multifunctionality are widely used as embolic materials, and can improve the efficacy of interventional therapy. In this review, we have described the status of research on hydrogels and challenges in the field of HCC therapy. First, various preparation methods of hydrogels through different cross-linking methods are introduced, then the functions of hydrogels related to HCC are summarized, including different HCC therapies, various imaging techniques, in vitro 3D models, and the shortcomings and prospects of the proposed applications are discussed in relation to HCC. We hope that this review is informative for readers interested in multifunctional hydrogels and will help researchers develop more novel embolic materials for interventional therapy of HCC. Graphical Abstract

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“…The prolonged residence of functional inorganic nanoparticles within the body raises considerable biosafety concerns on long-term toxicity for in vivo applications [ 4 – 7 ]. Of particular attention, in the context of nuclear medicine applications, the extended retention of functional inorganic nanoparticles labeled radionuclides may increase the exposure of undesired radiation [ 8 , 9 ]. To mitigate these potential concerns, concerted efforts have been directed toward rapid elimination and metabolism of those nanoparticles [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging

Chen,

Huang,

Zhang

et al. 2024

J Nanobiotechnol

1

0

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Background The general sluggish clearance kinetics of functional inorganic nanoparticles tend to raise potential biosafety concerns for in vivo applications. Renal clearance is a possible elimination pathway for functional inorganic nanoparticles delivered through intravenous injection, but largely depending on the surface physical chemical properties of a given particle apart from its size and shape. Results In this study, three small-molecule ligands that bear a diphosphonate (DP) group, but different terminal groups on the other side, i.e., anionic, cationic, and zwitterionic groups, were synthesized and used to modify ultrasmall Fe3O4 nanoparticles for evaluating the surface structure-dependent renal clearance behaviors. Systematic studies suggested that the variation of the surface ligands did not significantly increase the hydrodynamic diameter of ultrasmall Fe3O4 nanoparticles, nor influence their magnetic resonance imaging (MRI) contrast enhancement effects. Among the three particle samples, Fe3O4 nanoparticle coated with zwitterionic ligands, i.e., Fe3O4@DMSA, exhibited optimal renal clearance efficiency and reduced reticuloendothelial uptake. Therefore, this sample was further labeled with 99mTc through the DP moieties to achieve a renal-clearable MRI/single-photon emission computed tomography (SPECT) dual-modality imaging nanoprobe. The resulting nanoprobe showed satisfactory imaging capacities in a 4T1 xenograft tumor mouse model. Furthermore, the biocompatibility of Fe3O4@DMSA was evaluated both in vitro and in vivo through safety assessment experiments. Conclusions We believe that the current investigations offer a simple and effective strategy for constructing renal-clearable nanoparticles for precise disease diagnosis. Graphical Abstract

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“…The prolonged residence of functional inorganic nanoparticles within the body raises considerable biosafety concerns on long-term toxicity for in vivo applications [4][5][6][7]. Of particular attention, in the context of nuclear medicine applications, the extended retention of functional inorganic nanoparticles labeled radionuclides may increase the exposure of undesired radiation [8,9]. To mitigate these potential concerns, concerted efforts have been directed toward rapid elimination and metabolism of those nanoparticles [10].…”

Section: Introductionmentioning

confidence: 99%

Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging

Chen,

Huang,

Zhang

et al. 2024

Preprint

0

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Background The general sluggish clearance kinetics of functional inorganic nanoparticles tend to raise potential biosafety concerns for in vivo applications. Renal clearance is a possible elimination pathway for functional inorganic nanoparticles delivered through intravenous injection, but largely depending on the surface physical chemical properties of a given particle apart from its size and shape. Results In this study, three small-molecule ligands that bear a diphosphonate (DP) group, but different terminal groups on the other side, i.e., anionic, cationic, and zwitterionic groups, were synthesized and used to modify ultrasmall Fe3O4 nanoparticles for evaluating the surface structure-dependent renal clearance behaviors. Systematic studies suggested that the variation of the surface ligands did not significantly increase the hydrodynamic diameter of ultrasmall Fe3O4 nanoparticles, nor influence their magnetic resonance imaging (MRI) contrast enhancement effects. Among the three particle samples, Fe3O4 nanoparticle coated with zwitterionic ligands, i.e., Fe3O4@DMSA, exhibited optimal renal clearance efficiency and reduced reticuloendothelial uptake. Therefore, this sample was further labeled with 99mTc through the DP moieties to achieve a renal-clearable MRI/single-photon emission computed tomography (SPECT) dual-modality imaging nanoprobe. The resulting nanoprobe showed satisfactory imaging capacities in a 4T1 xenograft tumor mouse model. Furthermore, the biocompatibility of Fe3O4@DMSA was evaluated both in vitro and in vivo through safety assessment experiments. Conclusions We believe that the current investigations offer a simple and effective strategy for constructing renal-clearable nanoparticles for precise disease diagnosis.

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The increasing potential of nuclear medicine imaging for the evaluation and reduction of normal tissue toxicity from radiation treatments

Cited by 7 publications

References 123 publications

Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging

Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging

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