The Increasing Trends in Cases of the Most Common Cancers in Saudi Arabia

Chaudhri, Eman; Fathi, Weam; Hussain, Fazal; Hashmi, Shahrukh K.

doi:10.2991/jegh.k.200515.001

Cited by 26 publications

(22 citation statements)

References 13 publications

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“…Abnormal levels of female estrogen and unhealthy eating habits are thought to be one of the causes of thyroid cancer. 15 , 16 Women are generally more susceptible to health care than men (for example, due to reproductive and perimenopausal factors), which might lead to additional opportunities for thyroid examination. 13 This might partly explain why the incidence of thyroid cancer in women is increasing, while the incidence in men remains generally stable.…”

Section: Discussionmentioning

confidence: 99%

Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019

Bao

Yuan

et al. 2021

Thoracic Cancer

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Background: To investigate the burden of thyroid cancer and its attributable risk factors in 204 countries and territories during 30 years. Methods: We extracted data from the Global Burden of Disease (GBD) 2019 database, including incidence, mortality, disability-adjusted life-years (DALYs), and the attributable risk factors of thyroid cancer from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to assess the changes in age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR). We also examined the associations between cancer burden and the sociodemographic index (SDI).

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Section: Discussionmentioning

confidence: 99%

Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019

Bao

Yuan

et al. 2021

Thoracic Cancer

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“…Worldwide, CRC is the most common cancer with high age-standardized incidence rates (ASIRs) in both sexes, 76 , 77 but it is not among the top ten carcinomas in the Saudi population. 78 Recent studies have reported an increasing trend in ASIRs of CRC in Riyadh, Mecca, and the Eastern region in both sexes. 70 The ASIR and age-standardized mortality rate (ASMR) of CRC in the Saudi community are estimated to be 13.1 and 6.3 per 100,000 people, respectively.…”

Section: Discussionmentioning

confidence: 97%

Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the GST, CYP450, and TP53 Genes Among Nonsmokers in the Saudi Community

Sindi¹,

Babalghith²,

Tayeb³

et al. 2021

IJGM

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Purpose Colorectal carcinoma (CRC) represents a considerable public health burden in Saudi Arabia. Several candidate genes and genetic variants have been associated with morbidity and mortality among patients with CRC. We explored whether allelic variants of the GSTM1, GSTT1, CYP450 (rs4646903 and rs1048943), and TP53 (rs1042522) genes predisposed nonsmoking Saudi individuals to increased risk for CRC. Patients and Methods DNA from buccal cells of 158 participants (80 with CRC and 78 healthy controls) were analyzed for five SNPs using conventional PCR and TaqMan genotyping assays. The SNPStats software was utilized to choose the best interactive inheritance mode for selected SNPs ( https://www.snpstats.net ). Results The mean age of diagnosis was 62.4±13.5 years (range, 40–83 years), with those aged 71–80 years and those aged 40–50 years accounting for the most diagnoses (35.7% and 28.6% of diagnosis, respectively). The GSTM1 and TP53 rs1042522 SNPs were associated with CRC (OR= 3.7; P < 0.0001, and OR= 1.6; P = 0.033, respectively). A plausible contribution to CRC was observed for the GSTM1 and TP53 rs1042522 SNPs ( x 2 Yates = 14.7; P = 0.00013, and x 2 Yates = 11.2; P = 0.0008, respectively), while the GSTT1 null variant did not affect risk. Heterozygosity in the CYP450 (rs4646903 and rs1048943 SNPs) was associated with a significant risk for CRC. The GSTM1 / GSTT1 and CYP450 rs4646903/rs1048943 SNP pairs were in linkage disequilibrium, and the associations were statistically significant ( P = 0.01 and P = 4.6x10 ‒7 , respectively). Conclusion The GSTM1 and TP53 rs1042522 variants can increase the development of CRC in Saudi nonsmokers. Even the presence of one copy of a variant allele in the CYP1A1 gene can predispose CRC risk. Additional studies should also examine other SNP combinations with lifestyle factors that may help prevent, rather than facilitate, colorectal tumorigenesis.

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“…The latter is the highest and the third common cancer amongst men and women, respectively. The agestandardized incidence rates and age-standardization mortality rates for CRC are 13.1 and 6.3 cases per 100,000 people for both sexes 27 . Risk factors such as excess weight, sedentary lifestyle, diet rich in processed food, smoking, inflammatory bowel disease were found to contribute to 60-65% of CRC for both genders.…”

Section: Crc Incidence and Mortality In Saudi Arabiamentioning

confidence: 97%

“…Risk factors such as excess weight, sedentary lifestyle, diet rich in processed food, smoking, inflammatory bowel disease were found to contribute to 60-65% of CRC for both genders. Family history, due to the high rate of consanguineous marriage, and genetic syndrome (familial adenomatous polyposis or Lynch syndrome) account for 25-30% and 5%, respectively [27][28][29] . Polymorphisms of the ADIPOQ 30 , XRCC1, RETN 31 , and vitamin D receptor VDR 32 due to low vitamin D intake, have also been associated with increased risk CRC among Saudi older population.…”

Section: Crc Incidence and Mortality In Saudi Arabiamentioning

confidence: 99%

Lifetime Attributable Risk Estimates of Secondary Cancer after External Radiotherapy among Colorectal Cancer Survivors in Saudi Arabia

Abolaban

Djouider

2021

Preprint

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Radiation-induced second cancer is one of the crucial late side effects of radiotherapy treatment of first cancer. Although the second cancer induction mechanism is not well understood yet, many factors are related to its occurrences, such as age at exposure, dose to the organ and surrounding tissues, treatment modalities, and family history of cancer. This study aims to provide long-term estimates of second cancer incidence amongst colon cancer survivors in Saudi Arabia. The lifetime attributable risk (LAR) after radiation treatment of the colon cancer was determined, between the age at exposure and up to 95 years, in a single-institution cohort of male and female cancer survivors whose age at treatment was in the range 43 to 85 years. Risk estimates varied significantly with age at exposure, gender, and organ dose.

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The Increasing Trends in Cases of the Most Common Cancers in Saudi Arabia

Cited by 26 publications

References 13 publications

Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019

Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019

Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the GST, CYP450, and TP53 Genes Among Nonsmokers in the Saudi Community

Lifetime Attributable Risk Estimates of Secondary Cancer after External Radiotherapy among Colorectal Cancer Survivors in Saudi Arabia

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