The Independent and Additive Effects of Exercise Training and Estrogen on Bone Metabolism

Bemben, Debra A.; Fetters, N.

doi:10.1519/00124278-200002000-00019

Cited by 3 publications

(4 citation statements)

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“…In our study, there was a slight but nonsignificant decrease in bone resorption. Moderate-intensity resistive exercise interventions with adequate durations (i.e., 12 months) in healthy early postmenopausal women have demonstrated the ability to preserve or increase bone mass (Kemmler et al, 2004;Wallace & Cumming, 2000), but high-intensity resistance exercise may be needed to effect change in markers of bone formation (Bemben & Fetters, 2000; Judge et al, 2005). The findings from this pilot study on bone outcomes warrant examination in a larger randomized trial of longer duration.…”

Section: Discussionmentioning

confidence: 99%

“…Exercise is also recognized as an important intervention to help preserve bone mass, particularly for the early postmenopausal woman without osteopenia or osteoporosis (North American Menopause Society, 2006). However, while aerobic exercise activities improve physical and psychological well-being for midlife women, exercise as a strategy to ameliorate bone loss in postmenopausal women requires an increased osteogenic stimulus (Bemben & Fetters, 2000; Lanyon, 1996). The results of exercise trials with weight loading in healthy postmenopausal women support the hypothesis that the skeleton responds to dynamic forces, leading to preservation or increases in bone mass in women (Bemben & Fetters, 2000; Kelly, Kelly, & Tran, 2001).…”

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confidence: 99%

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An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes

Knobf

Insogna²,

DiPietro

et al. 2008

Biological Research For Nursing

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Objective Weight gain and bone loss are commonly reported in breast cancer survivors. The purpose of this pilot study is to assess feasibility and explore the effect of an aerobic weight-loaded exercise intervention on bone remodeling, weight, and body composition. Design A one-group pre-posttest design was used to test a 16–24-week supervised walking exercise intervention among women within 2 years of menopause. Through Weeks 1–4, time and weight were progressively increased. By Week 5 and through the end of the intervention, a waist belt was loaded with 5 lb and participants spent 45 min on the treadmill 3 times/week. Bone remodeling was measured by serum biomarkers (N-terminal propeptides of type I collagen [NTX] and serum osteocalcin). Dual-energy absorptiometry scans assessed body composition. Data were collected at baseline and 16 and 24 weeks. Results The majority of the 26 participants were married, well educated, and employed, with a mean age of 51.3 years (SD = 6.2). The high adherence (M = 88.2%, SD = 6.8) demonstrated feasiblity. There were no significant changes in serum osteocalcin (p = .67), serum NTX (p = .31), lean muscle mass (p = .08), or percent fat mass for the group as a whole (p = .14), but fat mass increased for women on adjuvant endocrine therapy (p = .04). The women maintained their weight. Conclusions This novel exercise intervention for breast cancer survivors was feasible, and women otherwise at high risk for weight gain and bone loss maintained their weight and bone mass.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes

Knobf

Insogna²,

DiPietro

et al. 2008

Biological Research For Nursing

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“…Body hormones such as estrogen are regulated by physical activity, and the role of these in bone metabolism is a proven fact [40][41][42]. Physical activity that stimulates estrogen secretion can imitate the effects of hormone replacement therapy and can help osteoporotic menopausal women [43][44][45][46].…”

Section: Continuation Of Tablementioning

confidence: 99%

Impact of sprint training on bone health: a literature review of current evidence

Bali,

Panda,

Singh

et al. 2024

jour

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Specific impact of sprint training (ST) on bone health has yet to be fully explored, in particular how it affects bone mineral density (BMD) and bone structure.Aim. To investigate the ST and bone health relationship between athletes of different training intensities and nonathletes of different ages.Materials and methods. A search of databases PubMed, Embase, and Pedro was conducted from January 2009 to August 2023. The full texts of all potentially relevant studies were obtained and evaluated by three independent reviewers for inclusion.Results. The comprehensive review of eight studies indicates a positive influence of ST on bone health. Sprinters show higher cortical and trabecular BMD in the tibia than controls, with a noted age-related decline in BMD. Short distance runners demonstrate significantly better BMD, counter-movement jump performance, and grip strength compared to long-distance runners. These benefits are consistent across various age groups, including older athletes, with minimal age-related changes in mid-tibial BMD. ST is also associated with a 21% increase in tibial stress-strain index, indicating sustained bone strength, and a reduction in fracture risk in the elderly through downregulation of fracture-related microRNAs.Conclusion. ST significantly enhances bone health, particularly in improving BMD and bone microarchitecture. Incorporating ST into exercise routines may benefit athletes and older individuals. Further research is essential to understand the mechanisms and develop optimal training protocols for bone health.

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“…Therefore, achieving optimal bone health requires maximizing bone formation before this critical phase and minimizing bone resorption after it. Bone undergoes a continuous cycle of formation and resorption every 4-6 months, with formation overpowering absorption until peak BMD is reached [18]. Therefore, it has been suggested that if bone formation is inhibited in any way during childhood and adolescents, peak BMD may be negatively impacted,…”

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confidence: 99%

Preliminary Study: The Relationship between Selective Serotonin Reuptake Inhibitors and Bone Health and Muscle Function in College Students

BS¹

2014

J Osteopor Phys Act

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The Independent and Additive Effects of Exercise Training and Estrogen on Bone Metabolism

Cited by 3 publications

References 0 publications

An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes

An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes

Impact of sprint training on bone health: a literature review of current evidence

Preliminary Study: The Relationship between Selective Serotonin Reuptake Inhibitors and Bone Health and Muscle Function in College Students

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