The individual contribution of DSM 5 symptom clusters of PTSD, life events, and childhood adversity to frontal oscillatory brain asymmetry in a large sample of active combatants

Abstract

HighlightsHyperarousal and traumatic life events associated with right frontal oscillatory activity.Childhood stress interacts with mood-related symptoms in left frontal oscillatory activity.Intrusions related to left frontal beta band activity.Lateralized DLPFC function could underlie stress and memory dysregulation in PTSD.

Effects of an Allostatic Closed‐Loop Neurotechnology (HIRREM) on Brain Functional Connectivity Laterality in Military‐Related Traumatic Stress

“…Extensive evidence indicates a relationship between traumatic stress and hemispheric lateralization of brain activity 7–15 . To date, however, there has been little investigation regarding the presence of laterality patterns in network or brain regional connectivity under such conditions, and whether laterality patterns may change after a successful therapeutic intervention.…”

“… 6 Researchers have demonstrated asymmetrical patterns of activity, in frontal regions 7 – 11 and also temporoparietal regions. 7 , 8 , 12 – 15 Some of these investigations have been mo-tivated by a model positing that the left and right prefrontal cortices mediate approach and withdrawal behavioral tendencies, respectively, 16 and more recent studies have examined asymmetry with a focus on specific symptom clusters within PTSD 10 or on the basis of trait versus state physiology. 11 Another impetus for such studies is provided by the bihemispheric autonomic model (BHAM) that suggests that traumatic stress may produce dominant and maladaptive asymmetries in the activity of homologous brain regions responsible for efferent autonomic signaling.…”

“…Structural neuroimaging has shown asymmetrical volumes of the hippocampus, amygdala, and other limbic regions, 1–5 as well as in the cerebellum 6 . Researchers have demonstrated asymmetrical patterns of activity, in frontal regions 7–11 and also temporoparietal regions 7,8,12–15 . Some of these investigations have been motivated by a model positing that the left and right prefrontal cortices mediate approach and withdrawal behavioral tendencies, respectively, 16 and more recent studies have examined asymmetry with a focus on specific symptom clusters within PTSD 10 or on the basis of trait versus state physiology 11 .…”

Hybrid War and Its Psychological Consequences

“…People experiencing a traumatic event manifest maladaptive behavior, difficulty coping with stress and a tendency to abuse psychoactive substances. Initially, PTSD syndrome was thought to be unique among psychiatric-type disorders because it is caused by an easily identifiable factor in the form of a traumatic event (Moran, 2017). However, it turned out that the occurrence of PTSD is not always associated with a single event.…”

“…The latest DSM-5 classifies this disorder as associated with trauma and high stress. Additionally, this set of symptoms has been supplemented with a loss of pleasure (so-called anhedonic symptoms) (Moran, 2017).…”