The indoor air and asthma

Kelly, Libby A.; Erwin, Elizabeth A.; Platts-Mills, Thomas A.E.

doi:10.1097/mcp.0b013e32834db10d

Cited by 34 publications

(8 citation statements)

References 42 publications

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“…The allergic response to pets in humans, that is, to hair of pets, is known to be one of the most challenging issues in the modern allergy science [ 14 , 15 , 17 – 20 ]. Allergens of cats are the best studied types [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Golokhvast

2014

Journal of Immunology Research

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This paper presents an analysis of airborne biogenic particles (1 mkm–1 mm) found in the snow in several cities of the Russian Far East during 2010–2013. The most common was vegetational terraneous detritus (fragments of tree and grass leaves) followed by animal hair, small insects and their fragments, microorganisms of aeroplankton, and equivocal biological garbage. Specific components were found in samples from locations close to bodies of water such as fragments of algae and mollusc shells and, marine invertebrates (needles of sea urchins and shell debris of arthropods). In most locations across the Far East (Vladivostok, Khabarovsk, Blagoveshchensk, and Ussuriysk), the content of biogenic particles collected in the winter did not exceed 10% of the total particulate matter, with the exception of Birobidzhan and the nature reserve Bastak, where it made up to 20%. Most of all biogenic compounds should be allergic: hair, fragments of tree and grass leaves, insects, and microorganisms.

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Section: Resultsmentioning

confidence: 99%

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Golokhvast

2014

Journal of Immunology Research

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“…However, pet allergens were found not only in families with pets, but also in those without pets, and in public places, including communities and schools. 24 Thus, the exact aeroallergen to be avoided was difficult to identify. Specific immunotherapy (SIT) is the only disease-modifying treatment for AR, 25 and previous studies have reported that this treatment is clinically effective in desensitisation to pet allergens.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and trends of sensitisation to aeroallergens in patients with allergic rhinitis in Guangzhou, China: a 10-year retrospective study

et al. 2016

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ObjectiveTo investigate the prevalence and trends of sensitisation to common aeroallergens among outpatients with allergic rhinitis (AR) in Guangzhou, China, over the past decade.DesignA retrospective study; linear-by-linear association and simple linear regression were used to determine the trends in the prevalence of aeroallergen sensitisation.SettingOne grade-A hospital in Guangzhou, the largest city in southern China.ParticipantsA total of 5486 patients (2297 males and 2489 females) who visited the ear, nose and throat outpatient clinic, from January 2005 to December 2014, were enrolled. All patients who presented with nasal hyper-reactive symptoms and who completed serological allergy testing, measuring specific IgE (sIgE) in the serum, were included. Among them, 4085 participants (2269 males and 1816 females) were diagnosed as being patients with AR.Outcome measuresPrevalence and trends of sensitisation to various types of aeroallergens were assessed.ResultsThe overall prevalence of sIgE-mediated sensitisation to aeroallergens in these patients with AR were as follows: 84.4% for house dust mites (HDMs), 23.4% for pet allergens, 21.1% for cockroaches, 9.1% for mould allergens, 7.7% for tree pollen and 6.0% for weed pollen. When all patients with nasal hyper-reactivity were stratified by decade of age, increasing age was associated with a decrease in sIgE positivity by ∼5.13% (95% CI −7.28% to −2.98%, p<0.01). Within the past decade, the prevalence of sensitisation to pet allergens in patients with AR increased at an annual rate of 1.3% (95% CI 0.85% to 1.67%, p<0.01).ConclusionsThis study demonstrated that HDMs comprised the most common aeroallergen in Guangzhou. The prevalence of sensitisation to aeroallergens decreased with increasing age. During the past decade, the prevalence of sensitisation to pet allergens showed an upward trend, suggesting an urgent need for its prevention and treatment.

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“…in asthmatics were observed in the further analyses. These observations suggest that patients with asthma may have allergies to different environmental allergens such as cockroaches and pet allergens [39], [40], as well as house dust mites.…”

Section: Discussionmentioning

confidence: 94%

A Genome-Wide Association Study of Total Serum and Mite-Specific IgEs in Asthma Patients

et al. 2013

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Immunoglobulin E (IgE) is one of the central players in asthma and allergic diseases. Although the serum IgE level, a useful endophenotype, is generally increased in patients with asthma, genetic factors influencing IgE regulation in asthma are still not fully understood. To identify the genetic variations associated with total serum and mite-specific IgEs in asthmatics, a genome-wide association study (GWAS) of 657,366 single nucleotide polymorphisms (SNPs) was performed in 877 Korean asthmatics. This study found that several new genes might be associated with total IgE in asthmatics, such as CRIM1 (rs848512, P = 1.18×10−6; rs711254, P = 6.73×10−6), ZNF71 (rs10404342, P = 7.60×10−6), TLN1 (rs4879926, P = 7.74×10−6), and SYNPO2 (rs1472066, P = 8.36×10−6; rs1038770, P = 8.66×10−6). Regarding the association of specific IgE to house dust mites, it was observed that intergenic SNPs nearby to OPRK1 and LOC730217 might be associated with Dermatophagoides pteronyssinus (D.p.) and Dermatophagoides farinae (D.f.) in asthmatics, respectively. In further pathway analysis, the phosphatidylinositol signaling system and adherens junction pathways were estimated to play a role in the regulation of total IgE levels in asthma. Although functional evaluations and replications of these results in other populations are needed, this GWAS of serum IgE in asthmatics could facilitate improved understanding of the role of the newly identified genetic variants in asthma and its related phenotypes.

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The indoor air and asthma

Cited by 34 publications

References 42 publications

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Prevalence and trends of sensitisation to aeroallergens in patients with allergic rhinitis in Guangzhou, China: a 10-year retrospective study

A Genome-Wide Association Study of Total Serum and Mite-Specific IgEs in Asthma Patients

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