1988
DOI: 10.3109/00498258809041705
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The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes

Abstract: 1. The induction and inhibition of some biotransformation enzymes by valproate have been studied in hepatocytes isolated from rats treated with sodium valproate either i.p. or by subcutaneous implantation of osmotic pumps. 2. When valproate was given i.p., the cytochromes P-450 and b5, and aldrin epoxidase and glutathione S-transferase activities were significantly induced. 3. In contrast, valproate administered by osmotic pumps induced 7-ethoxycoumarin-O-deethylase activity, whereas aldrin expoxidase and glut… Show more

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Cited by 14 publications
(15 citation statements)
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“…The latter situation exposes the animals to very high serum concentrations (330+27 ~g/ml) (n = 4) for a short time. Between consecutive doses only a very low drug concentration is present (10 ~g/ml after 4 h; n = 4) [17].…”
Section: Discussionmentioning
confidence: 99%
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“…The latter situation exposes the animals to very high serum concentrations (330+27 ~g/ml) (n = 4) for a short time. Between consecutive doses only a very low drug concentration is present (10 ~g/ml after 4 h; n = 4) [17].…”
Section: Discussionmentioning
confidence: 99%
“…All reagents, materials and apparatus not mentioned here were described in detail in previously published work [17][18][19][20].…”
Section: Methodsmentioning
confidence: 99%
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“…Therefore, we wished to determine if the inducing and inhibiting effects of VPA on biotransformation systems reported by Rogiers et al (1988) are reflected in alterations of urinary excretion of VPA and metabolites.…”
mentioning
confidence: 99%