The Induction of Heme Oxygenase-1 Modulates Bismuth Oxide-induced Cytotoxicity in Human Dental Pulp Cells

Min, Kyung-San; Chang, Hoon-Sang; Bae, Ji-Myung; Park, Sanghyuk; Hong, Chan-Ui; Kim, Eun-Cheol

doi:10.1016/j.joen.2007.07.012

Cited by 77 publications

(65 citation statements)

References 24 publications

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“…In agreement with the previous report of Min et al (9), nitrite was detected in cell supernatants of extract-treated cells. However, the assessment of nitrite content of the extracts used as negative controls allowed us to observe that the origin of the nitrite content detected on the supernatants were the materials themselves.…”

Section: Discussionsupporting

confidence: 93%

“…One of the remarkable differences between these cements is the presence of bismuth oxide in MTA as an improvement to radiopacity. Min et al (9) reported that bismuth oxide added-PC led to increased NO release by cells in comparison with pure PC. Scelza et al (15) also observed better results for PC than MTA Fillapex for the extracts prepared 7 days after sealer/cement manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike regular MTA, MTA Fillapex was developed as a paste/paste sealer in a formulation that allows its appropriate insertion into the root canal as a conventional endodontic sealer (8,9).…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Cytotoxicity of White MTA, MTA Fillapex® and Portland Cement on Human Periodontal Ligament Fibroblasts

et al. 2013

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The aim of this study was to compare the in vitro cytotoxicity of white mineral trioxide aggregate (MTA), MTA Fillapex ® and Portland cement (PC) on human cultured periodontal ligament fibroblasts. Periodontal ligament fibroblast culture was established and the cells were used for cytotoxic tests after the fourth passage. Cell density was set at 1.25 x10 4 cells/well in 96-well plates. Endodontic material extracts were prepared by placing sealer/ cement specimens (5x3mm) in 1mL of culture medium for 72 h. The extracts were then serially two-fold diluted and inserted into the cell-seeded wells for 24, 48 and 72 h. MTT assay was employed for analysis of cell viability. Cell supernatants were tested for nitric oxide using the Griess reagent system. MTA presented cytotoxic effect in undiluted extracts at 24 and 72 h. MTA Fillapex ® presented the highest cytotoxic levels with important cell viability reduction for pure extracts and at ½ and ¼ dilutions. In this study, PC did not induce alterations in fibroblast viability. Nitric oxide was detected in extract-treated cell supernatants and also in the extracts only, suggesting presence of nitrite in the soluble content of the tested materials. In the present study, MTA Fillapex displayed the highest cytotoxic effect on periodontal ligament fibroblasts followed by white MTA and PC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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In Vitro Cytotoxicity of White MTA, MTA Fillapex® and Portland Cement on Human Periodontal Ligament Fibroblasts

et al. 2013

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“…In common with MTA, it contains bismuth oxide to provide radiopacity. Although bismuth oxide provides sufficient radiopacity, there are several reports showing that it has harmful effects stemming from its biological and mechanical properties [23][24][25][26] . Among possible alternatives to bismuth oxide, zirconium oxide (ZrO 2) was investigated as a candidate because of its adequate radiopacity and cost-effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

et al. 2015

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A fast-setting calcium-silicate cement (Endocem) was introduced in the field of dentistry for use in vital pulp therapy. Similar to mineral trioxide aggregate (MTA), it contains bismuth oxide to provide radiopacity. Recently, another product, EndocemZr, which contains zirconium oxide (ZrO2) as a radiopacifier, was developed by the same company. In this study, the biological/odontogenic effects of EndocemZr were investigated in human primary dental pulp cells (hpDPCs) in vitro and on capped rat teeth in vivo. The biocompatibility of EndocemZr was similar to that of ProRoot and Endocem on the basis of cell viability tests and cell morphological analysis. The mineralization nodule formation, expression of odontogenic-related markers, and reparative dentin formation of EndocemZr group was similar to those of other material groups. Our results suggest that EndocemZr has the potential to be used as an effective material for vital pulp therapy, similar to ProRoot and Endocem.

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“…Ocorre um aumento de porosidade e diminuição na resistência às forças de compressão do cimento (COOMARASWAMY; LUMLEY; HOFMANN, 2007). Além disso, o óxido de bismuto apresenta toxicidade e pode afetar o crescimento e proliferação celular (MIN, et al, 2007) e induzir a morte celular (CAMILLERI, et al, 2004). Assim, alguns autores sugerem a substituição deste radiopacificador por outra substância que promova uma radiopacidade adequada para ser distinguido das estruturas anatômicas e, ao mesmo tempo não interfira nas propriedades do cimento.…”

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Propriedades físico-químicas e biológicas de cimento experimental à base de Portland associado a diferentes radiopacificadores

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The Induction of Heme Oxygenase-1 Modulates Bismuth Oxide-induced Cytotoxicity in Human Dental Pulp Cells

Cited by 77 publications

References 24 publications

In Vitro Cytotoxicity of White MTA, MTA Fillapex® and Portland Cement on Human Periodontal Ligament Fibroblasts

In Vitro Cytotoxicity of White MTA, MTA Fillapex® and Portland Cement on Human Periodontal Ligament Fibroblasts

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

Propriedades físico-químicas e biológicas de cimento experimental à base de Portland associado a diferentes radiopacificadores

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