The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway

Uto, Takuhiro; Akagi, Takami; Yoshinaga, Keisuke; Toyama, Masaaki; Akashi, Mitsuru; Baba, Masanori

doi:10.1016/j.biomaterials.2011.03.052

Cited by 122 publications

(98 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poly(gamma-glutamic acid) nanoparticle-mediated immune reaction involves TLR4 and its adaptor protein MyD88 because immune cells from MyD88-knockout mice exhibit a lower level of inflammatory reactions than those from wild-type mice. 159 However, the total loss of expression of TLR4 by gene knockout does not suppress completely the induction of immune responses by nanoparticles; an observation that suggests the complexity of nanoparticles' interactions with the immune system and the possibility of other players in such responses. 159 In summary, nanoparticles exhibit the properties of immune adjuvants and immunosuppressors.…”

Section: 152mentioning

confidence: 99%

“…159 However, the total loss of expression of TLR4 by gene knockout does not suppress completely the induction of immune responses by nanoparticles; an observation that suggests the complexity of nanoparticles' interactions with the immune system and the possibility of other players in such responses. 159 In summary, nanoparticles exhibit the properties of immune adjuvants and immunosuppressors. In mice, they activate the complement system and decrease the population of lymph node cells that produce immunoglobulins against immunogens.…”

Section: 152mentioning

confidence: 99%

See 1 more Smart Citation

Perturbation of physiological systems by nanoparticles

et al. 2014

View full text Add to dashboard Cite

Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

show abstract

Section: 152mentioning

confidence: 99%

Section: 152mentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Additionally, studies show that these biodegradable nanoparticles induce in vitro innate immune cell activation, produce antigen-specific immune responses in vivo through the TLR 4 and MyD88-dependent signaling pathway, and can influence innate and adaptive immune responses by first-line host sensor [111].…”

Section: Poly(gamma-glutamic Acid)mentioning

confidence: 99%

Genetic toxicology and preliminaryin vivostudies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

Cabrera

López

Gómez

et al. 2011

Drug and Chemical Toxicology

View full text Add to dashboard Cite

In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of allergic diseases. However, current allergen immunotherapy shows limitations concerning the long-term efficacy and safety due to local side effects and risk of anaphylaxis. Thus, effective and safe vaccines with reduced dose of allergen have been developed using adjuvants. Nevertheless, the use of adjuvants still has several disadvantages, which limits its use in human vaccines. In this context, several novel adjuvants for allergen immunotherapy are currently being investigated and developed. Currently, nanoparticles-based allergen-delivery systems have received much interest as potential adjuvants for allergen immunotherapy. It has been demonstrated that the incorporation of allergens into a delivery system plays an important role in the efficacy of allergy vaccines. Several nanoparticles-based delivery systems have been described, including biodegradable and nondegradable polymeric carriers. Therefore, this paper provides an overview of the current adjuvants used for allergen immunotherapy. Furthermore, nanoparticles-based allergen-delivery systems are focused as a novel and promising strategy for allergy vaccines.

show abstract

“…They are the first line of defense in immune reactions [3]. In addition, TLRs can induce activation of T-lymphocytes, regulate and control adaptive immunity, and maintain balance of body immune system [4]. Studies have shown that TLR2 and TLR4 participate in the recognition of TB and associated metabolites, and promote inflammatory responses against them [5,6].…”

Section: Introductionmentioning

confidence: 99%

Expressions of toll-like receptors 2 and 4, and relative cellular factors in HIV patients with tuberculosis infection

Chen¹,

Li²,

Wang³

et al. 2017

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To investigate the expressions of toll-like receptor 2 (TLR2), toll-like receptor 4 (TLR4), tumor necrosis factor alpha (TNF-α), IFN-γ (IFN-gamma), interleukin 2 (IL-2), interleukin 6 (IL-6) and interleukin 10 (IL-10) in human immunodeficiency virus (HIV) patients with tuberculosis (TB) infection. Methods: Two groups of HIV patients (68 in each group) were used for this study. These were HIV with TB (HIV/TB) group and HIV without TB group. A third group (68 healthy people) served as control. Quantitative polymerase chain reaction (qPCR) was adopted to measure TLR-2 and TLR-4 expressions in peripheral blood mononuclear cells (PBMC), while the serum levels of TNF-α, IFN-γ, IL-2, IL-6 and IL-10 were determined by ELISA. Results: The △Ct values of TLR-2 and TLR-4 in HIV/TB and HIV groups were significantly lower than those in the control group (p < 0.05). Compared to control group, the serum levels of TNF-α, IL-6 and IL-10 significantly increased, while IFN-γ and IL-2 in HIV/TB and HIV groups significantly decreased (p < 0.05). However, IFN-γ and IL-2 decreased significantly in HIV/TB group (p < 0.05). Expression of TLR2correlated positively with serum levels of

show abstract

The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway

Cited by 122 publications

References 30 publications

Perturbation of physiological systems by nanoparticles

Perturbation of physiological systems by nanoparticles

Genetic toxicology and preliminaryin vivostudies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

Expressions of toll-like receptors 2 and 4, and relative cellular factors in HIV patients with tuberculosis infection

Contact Info

Product

Resources

About