1989
DOI: 10.1016/0165-5728(89)90030-1
|View full text |Cite
|
Sign up to set email alerts
|

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
64
0

Year Published

1990
1990
2003
2003

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 205 publications
(66 citation statements)
references
References 15 publications
2
64
0
Order By: Relevance
“…Perhaps the few CD6-positive cells scattered in normal CNS tissue may represent cells in a 'be prepared' condition confirming the increasing evidence for the immunocompetence of the CNS. Possibly brain cells can be induced to express CD6 antigen in response to an immunological stimulus as shown for MHC class II and intercellular adhesion molecule 1 (ICAM-1) (Massa and ter Meulen, 1987;Frohmann et al, 1989). Up to now only the stimulating effect of different anti-CD6 mabs on mature T cells has been shown (Rieber et al, 1986;Swack et al, 1988).…”
Section: Discussionmentioning
confidence: 99%
“…Perhaps the few CD6-positive cells scattered in normal CNS tissue may represent cells in a 'be prepared' condition confirming the increasing evidence for the immunocompetence of the CNS. Possibly brain cells can be induced to express CD6 antigen in response to an immunological stimulus as shown for MHC class II and intercellular adhesion molecule 1 (ICAM-1) (Massa and ter Meulen, 1987;Frohmann et al, 1989). Up to now only the stimulating effect of different anti-CD6 mabs on mature T cells has been shown (Rieber et al, 1986;Swack et al, 1988).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, astrocytes can release a variety of modulatory substances, including neurotransmitters [adenosine triphosphate (ATP), glutamate], growth factors [nerve growth factor (NGF), neurotrophin-3 NT-3), basic fibroblast growth factor (bFGF)], and cytokines (ICAM), to which neurons respond (Frohman et al, 1989;Dani et al, 1992;Condorelli et al, 1995;Kuzis et al, 1995;Araque et al, 1998). Thus, although brain function has been traditionally thought of in terms of neuronal activity, glial cells can also generate signals that affect their neuronal counterparts (Fig.…”
Section: Astrocytes As Active Participantsmentioning
confidence: 99%
“…ates leukocyte cell adhesion and antigen-specific T-cell activation by binding to /^-integrin molecules, such as The intercellular adhesion molecule-1 (ICAM-1, lymphocyte function-associated molecule-1 (LFA-1, CD54) is expressed on endothelial cells, astrocytes, CD1 la/18) and complement receptor type 3 (Mac-1, microglia, and B-and T-lymphocytes and is up-regulated CD 1 lb/18), expressed on leukocytes and macrophages in response to various stimuli (Frohman et al, 1989;(Smith et al, 1989;Diamond et al, 1990; Dustin and Satoh et al, 1991a;Sobel et al, 1990). ICAM-1 medi-Springer, 1988;Rothlein et al, 1986 (Rothlein et al, 1991;Seth et al, 1991).…”
Section: Introductionmentioning
confidence: 99%
“…Transient (Abelda et al, 1994;Carlos and Harlan, 1994;Rössler et al, 1992;Zimmermann et al, 1992). Leukocytes transmigrated into the brain release pro-inflammatory cytokines such as IL-1, IL-6, interferon (IFN)--y, and tumor necrosis factor (TNF)-a, which, in turn, up-regulate the expression of ICAM-1 on various cell types (Aloisi et al, 1992;Fabry et al, 1992;Frohman et al, 1989;Satoh et al, 1991b) and produce cytotoxic agents such as glutamate, oxygen radicals, and proteolytic enzymes (Zhuang et al, 1993). The release of pro-inflammatory cytokines (Kossmann et al, 1996(Kossmann et al, , 1997Morganti-Kossmann et al, 1997) and neurotoxins (e.g., glutamate) within the brain is thought to aggravate BBB damage, leading to vasogenic and cytotoxic brain edema formation (Greenwood, 1991;Weckerle, 1993), possibly resulting in a self-sustaining vicious circle (Cross et al, 1991;Staub et al, 1996).…”
Section: Introductionmentioning
confidence: 99%