The Induction of Intracranial Neoplasms by the Inoculation of Avian Sarcoma Virus in Perinatal and Adult Rats

Abstract

The induction of intracranial neoplasms following the intracerebral inoculation of avian sarcoma virus (ASV) in neonatal mammals is well established. The present study demonstrates the susceptibility of adult rats and compares the incidence and morphology of tumors induced by a uniform inoculum of the Bratislava-77 strain of ASV in adult, neonatal, and fetal Fischer 344 rats. Post-inoculation mortality varied significantly between groups inoculated at 1, 10 and 100 days and was most precipitous in perinatally inoculated rats. Percentage of tumor induction declined from 100% among rats inoculated at 1 day of age to 50% among rats inoculated at 100 days of age. The mean number of tumors/animal was inversely proportional to the logarithm of the age at inoculation. A large majority of tumors in each group were glial; the remainder were mesenchymal and mixed glial and mesenchymal. Neuroglial tumors included: mixed gliomas with oligodendroglial and astrocytic elements; and gemistocytic, pilocytic, fibrillary, anaplastic and protoplasmic astrocytomas. Tumors induced in perinates were more heterogeneous in histological pattern while tumors induced in perinates were more heterogeneous in histological pattern while tumors induced in older animals tended to be purely astrocytic and of uniform cell type. Mesenchymal tumors occurred primarily in the meninges and were common among animals inoculated perinatally but were rare among animals inoculated as adults. No neuronal tumors were encountered even among rats inoculated as early as 16 days of gestation.

Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China

“…In contrast, Menegoz (30) did not detect an association between contact with sheep and the risk of brain tumors. Possible explanations for a relation with wool exposure are unclear, although employment in wool processing has been shown to cause infectious disease (31)(32)(33), and infectious etiologies for brain tumors have been hypothesized (34,35).…”

Avian retrovirus infection causes naturally occurring glioma: Isolation and transmission of a virus from so-called fowl glioma

“…Avian retroviruses (avian leukosis/sarcoma group) cause variable malignant neoplasms in chickens (Beard, 1980;Payne & Fadly, 1997). Rous sarcoma virus (RSV) in this group induces neurogenic tumours in many species following intracerebral inoculation (Copeland et al, 1976;Beard, 1980). Although chickens inoculated with RSV develop meningioma (Vasquez-Lopez, 1936;Beard, 1980), the relationship between the neoplasm and RSV is still unclear.…”

Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats

“…RT-2 is derived from an avian sarcoma virus-induced brain tumor in the Fischer 344 rat. 25 ECV304 is an immortalized human umbilical vein endothelial cell (HUVEC) line. 26,27 Both RT-2 and ECV304 cells were maintained in Dulbecco's Modified Eagle's Medium (DMEM; Seromed, Berlin, Germany) that was supplemented with 10% fetal calf serum (FCS; Biological Industries, Israel), 2 mM Lglutamate, 100 U/mL penicillin and 100 lg/mL streptomycin.…”