The Induction of New Bone and Cementum Formation III. Utilizing Bone and Marrow Allografts in Dogs

Abstract

TISSUE GRAFTING from a genetically dissimilar donor of the same species will generally incite an immunologic response resulting in rejection of the allograft. While homoviable grafts are most often rejected, some homostatic grafts are eventually replaced by living elements of the recipients. These include cortical bone, 1 blood vessels 2 and cornea. 3Assuming that all successful grafts are ultimately replaced by host tissue, it seems reasonable to question the possible fate of a viable allograft consisting of bone and marrow in a periodontal lesion. Would such a graft elicit antibody formation sufficient to cause rejection within a short period of time, or would rejection occur slowly, permitting progressive resorption and repair with eventual replacement of the graft with formed bone?To answer this question, a periodontal bone and marrow grafting experiment was designed to compare host response in animals receiving an immunosuppressant drug, which will decrease reactivity to antigens, and the

Periodontal Scleral Grafts and Combined Grafts of Sclera and Bone: Two‐Year Appraisal

“…[1][2][3][4] The limited availability and the additional trauma associated with obtaining autogenous tissues have led to studies of allografts for periodontal tissue augmentation. [5][6][7] Based on reports of the effective repair of small osseous defects in rhinoplasty, the author conducted and reported on clinical trials of scleral allografts for bone repair in periodontal surgery. 8,9 The initial studies showed scleral allografts to be well accepted by the periodontal tissues and capable of forming an attachment to bone or gingiva.…”