The induction of oestrus in mares by uterine infusion of saline

Arthur, GH

doi:10.1136/vr.86.20.584

Cited by 17 publications

(13 citation statements)

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“…Days 4-9 (Day 0 = ovulation) (Arthur, 1970;Neely et al, 1975;Douglas & Ginther, 1972;Allen & Rowson, 1973). Experiment I.…”

Section: Methodsmentioning

confidence: 99%

“…Luteolysis occurs with doses of prostaglandin (PG) F-2a as low as 1-25 mg (Douglas & Ginther, 1972), although 30 mg PGF-2a are needed to induce luteolysis in cows (Oxender, Noden, Louis & Hafs, 1974). Mares also respond with luteolysis after intrauterine infusion of normal saline, a non-irritating substance (Arthur, 1970(Arthur, , 1975Neely, Hughes, Stabenfeldt & Evans, 1975), while in cows and sheep, foreign bodies or irritating substances have to be placed in the uterus to cause a luteolytic response (Moore & Nalbandov, 1953;Yamauchi, Nakahara, Keneda & Inui, 1967;Nakahara, Domeki & Yamauchi, 1971;Sequin, Morrow & Oxender, 1974). It might, therefore, be expected that the mare would respond to the luteolytic effects of oxytocin as demonstrated for cattle (Armstrong & Hansel, 1959), possibly via the ability of oxytocin to release PGF-2a as in the ewe (Sharma & Fitzpatrick, 1974).…”

Section: Introductionmentioning

confidence: 99%

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The effect of exogenous oxytocin on luteal function in mares

Neely¹,

Stabenfeldt²,

Sauter³

1979

Reproduction

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Daily injections of 150 units oxytocin administered to 6 mares on Days 4, 5, 6, 7 and 8 after ovulation (Day 0 = ovulation) failed to induced luteolysis as indicated by the maintenance of normal plasma progestagen concentrations and the occurrence of normal ovulatory intervals. Three additional mares were given oestrogen injections 24 h before an injection of oxytocin on Day 7 after ovulation, but this treatment also failed to induce luteolysis since plasma progestagen concentrations were maintained in all three mares. Two mares exhibited normal ovulatory intervals, while the third developed a corpus luteum which persisted for 46 days.

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“…Days 4-9 (Day 0 = ovulation) (Arthur, 1970;Neely et al, 1975;Douglas & Ginther, 1972;Allen & Rowson, 1973). Experiment I.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of exogenous oxytocin on luteal function in mares

Neely¹,

Stabenfeldt²,

Sauter³

1979

Reproduction

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“…lateralized to the side of the CL [36]. An early observation of Arthur [4] was that intra-uterine infusions of saline caused anoestrous mares to return to heat. This form of treatment is in common use in veter inary circles, and may well be indicative of a uterine effect on the CL, although the endocrinology of the mare has not been well worked out.…”

Section: Comparative Aspects O F Mammalian Luteolytic Mechanismsmentioning

confidence: 99%

Prostaglandin F<sub>2α</sub>, ‘the' Luteolysin in the Mammal?

Goding¹,

Cumming²,

Chamley³

et al. 1971

Gynecol Obstet Invest

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Part. I: Prostaglandin F₂_Α (PGF_2Α) was shown to be ‘the’ luteolysin in the ewe on the following criteria: (1) Hysterectomy and/or separation of the uterine horn from the ovary bearing a corpus luteum led to prolongation of the oestrous cycle, (2) PGF_2Αshortened the cycle when administered in the midluteal phase, (3) PGF_2Α was identified in uterine venous blood, (4) a mechanism for the transfer of PGF_2Α from the uterine vein to the ovarian artery was shown to exist, (5) the quantitative aspects of the secretion transfer mechanism and luteolytic potency of PGF_2Α were adequate to account for the observed phenomena. Part II: These criteria were applied for evaluation of PGF_2Α as ‘the’ luteolysin in the following species: cattle, goat, horse, pig, guinea pig, rat, hamster, rabbit, monkey, human. On present knowledge, there appeared to be a variation between species from those in which PGF_2Α was probably concerned in luteolysis and those in which the evidence was against such a role. Part III: PGF_2Α was shown to be luteolytic when given by continuous infusion for 3–6 h into the lumen of the uterus in cattle as well as sheep. The minimum effective dose was of the order of 7 g/kg. The application of this finding to artificial insemination programmes was discussed.

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“…Proctor (l953), Burkhardt (1954), Roberts (1956), Day ( 1957), Bain (1 957), du Plessis ( 1964), Zafrakas (1 964), Wayland (1964) and van Niekerk (1965) have reported the use of I U infusion to initiate signs of oestrus in anoestrous mares, or in mares found open on pregnancy examinations but failing to return to heat. Arthur (1968Arthur ( , 1970) studied the influence of IU saline in the mare as to its effect at different stages of the oestrous cycle and at different seasons of the year, while Loy, Prickett and Whitehead (1971), and Ginther and Meckley (1972) reported on its effect at various periods in the oestrous cycle. Their findings indicate that IU saline during oestrus and late in dioestrus have little effect on cycle length.…”

Section: Introductionmentioning

confidence: 99%

“…Saline infusion beginning about day 4 postovulation, however, did shorten the cyclic ovulatory interval. Arthur (1968Arthur ( , 1970 found that anoestrous mares from November to early February did not respond with oestrus to IU saline infusions. The anoestrous mares from February to April responded with oestrus in one to six days, but the follicles underwent atresia.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Intrauterine Saline Infusion on Luteal Function and Cyclic Ovarian Activity in the Mare

Neely

Stabenfeldt

et al. 1974

Equine Veterinary Journal

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SUMMARY IU saline infusion in the mare shortened the cyclic ovulatory interval through the initiation of corpora lutea regression. The plasma progestin levels began to decrease approximately one day following the infusion and declined to < 1.0 ng/ml by 4 days post‐treatment. Six of the 10 mares responded to IU saline infusion on the 4th or 5th day postovulation with a shortened cyclic ovulatory interval of 14.8 days. The interval from saline infusion to oestrus was 6.2 days and to ovulation 10.5 days. Seven of the 10 mares responded to saline infusion on day 6 or 7 postovulation with a shortened cyclic ovulatory interval of 16.0 days. The interval from saline infusion to oestrus was 5.3 days and to ovulation 9.1 days. The three mares not responding to treatment at this time had dioestrus (midcycle) ovulations near the time of the infusion. The presence of an active corpus luteum is required for IU saline infusion to induce oestrus and to shorten the cyclic ovulatory interval. The corpora lutea, including those formed from dioestrous ovulations, must be of sufficient maturity (4 to 5 days postovulation) to be responsive to the lytic effects of IU saline infusion. RÉSUMÉ En provoquant une régression du corps jaune l'injection intra utérine d'une solution saline a d'une manière générale raccourci la durée des cycles ovulatoires. Les taux plasmatiques de Progestin ont commencé de décroitre environ 1 jour après l'administration pour atteindre un taux infèrieur à 1.0 mg/ml 4 jours plus tard. Six des dix juments traitées montrèrent une réponse à l'irrigation vers le 4° ou le 5° jour suivant l'ovulation avec un intervalle cyclique entre deux ovulations de 14.8 jours. L'intervalle entre l'injection saline et l'apparition des chaleurs fut de 6.2 jours et entre l'injection et l'ovulation de 10.5 jours. Pour sept juments sur dix lorsque l'injection intra utérine était pratiquée vers le 6° ou le 7° jour suivant l'ovulation l'intervalle entre deux cycles était de 16.0 jours. L'intervalle entre l'irrigation et l'apparition de l'oestrus était alors de 5.3 jours, entre l'irrigation et l'ovulation de 9.1 jours. Les trois juments réfractaires étaient en dioestrus lors de l'irrigation. La présence d'un corps jaune en activité est nécessaire pour que l'irrigation saline puisse réduire l'oestrus et raccourcir le cycle ovulatoire. Le corps jaune doit avoir une maturité suffisante (4 ou 5 jours après l'ovulation) pour subir l'action lytique de l'irrigation saline. ZUSAMMENFASSUNG Die intrauterine Infusion von physiologischer Kochsalzlösung verkürzte das zyklische Ovulationsintervall durch die Beschleunigung der Gelbkörperregression. Die Plasma‐Progestinspiegel begannen ungefähr einen Tag nach der Infusion abzufallen bis auf <1.0 mg/ml am 4. Tag nach der Behandlung. Sechs der zehn Stuten beantworteten die Infusion am 4. oder 5. Tag nach der Ovulation mit einem verkürzten Zyklus von 14.8 Tagen. Das Intervall zwischen Infusion und Oestrus betrug 6.2 Tage, zwischen Infusion und Ovulation 10.5 Tage. Sieben der zehn Stuten, denen die Kochsalz...

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The induction of oestrus in mares by uterine infusion of saline

Cited by 17 publications

References 0 publications

The effect of exogenous oxytocin on luteal function in mares

The effect of exogenous oxytocin on luteal function in mares

Prostaglandin F<sub>2α</sub>, ‘the' Luteolysin in the Mammal?

The Influence of Intrauterine Saline Infusion on Luteal Function and Cyclic Ovarian Activity in the Mare

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