The Infective Dose of Aerobic and Anaerobic Bacteria in Postoperative Wound Sepsis

Raahave, D

doi:10.1001/archsurg.1986.01400080070012

Cited by 72 publications

(32 citation statements)

References 24 publications

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“…The risk of infection is generally based on the susceptibility of a surgical wound to microbial contamination (196). Clean surgery carries a 1 to 5% risk of postoperative wound infection, and in dirty procedures that are significantly more susceptible to endogenous contamination, a 27% risk of infection has been estimated (174).…”

Section: Wound Infectionmentioning

confidence: 99%

“…In contrast, Pruitt et al (194) reported that quantitative cultures are incapable of differentiating between burn wound colonization and infection, and they described histological analysis as being the most effective and rapid method for determining invasive burn wound infection. Raahave et al (196), using a velvet pad surface imprint technique, reported that the median infective dose of mixed aerobes and anaerobes in postsurgical wounds was 4.6 ϫ 10 5 CFU/cm 2 , and Majewski et al (150), using a surface swab method, demonstrated that skin grafting was more successful in patients with wound contamination of Ͻ5 ϫ 10 4 CFU/cm 2 . A dermabrasion technique, considered to quantify tissue colonization while minimizing the degree of tissue invasion in burn wounds, has been shown to be more sensitive, both qualitatively and quantitatively, than a surface sample procedure (181).…”

Section: Significance Of Microorganisms In Woundsmentioning

confidence: 99%

“…Thus, quantitative analysis of superficial tissue may also have a role to play in predicting the risk of wound infection (150,196), and several studies have demonstrated a correlation between surface cultures and tissue biopsy cultures. Levine (28), which compares with deep-tissue biopsy specimen mean isolation rates of 2.3 aerobes and 2.4 anaerobes per infected diabetic ulcer (214).…”

Section: Significance Of Microorganisms In Woundsmentioning

confidence: 99%

“…One school of thought is that the density of microorganisms is the critical factor in determining whether a wound is likely to heal (100,102,151,196,202). However, a second school of thought argues that the presence of specific pathogens is of primary importance in delayed healing (59,130,149,181,216,217), while yet others have reported microorganisms to be of minimal importance in delayed healing (4,70,80,95,98,214,237).…”

Section: Introductionmentioning

confidence: 99%

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Wound Microbiology and Associated Approaches to Wound Management

2001

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The majority of dermal wounds are colonized with aerobic and anaerobic microorganisms that originate predominantly from mucosal surfaces such as those of the oral cavity and gut. The role and significance of microorganisms in wound healing has been debated for many years. While some experts consider the microbial density to be critical in predicting wound healing and infection, others consider the types of microorganisms to be of greater importance. However, these and other factors such as microbial synergy, the host immune response, and the quality of tissue must be considered collectively in assessing the probability of infection. Debate also exists regarding the value of wound sampling, the types of wounds that should be sampled, and the sampling technique required to generate the most meaningful data. In the laboratory, consideration must be given to the relevance of culturing polymicrobial specimens, the value in identifying one or more microorganisms, and the microorganisms that should be assayed for antibiotic susceptibility. Although appropriate systemic antibiotics are essential for the treatment of deteriorating, clinically infected wounds, debate exists regarding the relevance and use of antibiotics (systemic or topical) and antiseptics (topical) in the treatment of nonhealing wounds that have no clinical signs of infection. In providing a detailed analysis of wound microbiology, together with current opinion and controversies regarding wound assessment and treatment, this review has attempted to capture and address microbiological aspects that are critical to the successful management of microorganisms in wounds

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Section: Wound Infectionmentioning

confidence: 99%

Section: Significance Of Microorganisms In Woundsmentioning

confidence: 99%

Section: Significance Of Microorganisms In Woundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Wound Microbiology and Associated Approaches to Wound Management

2001

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“…The occurrence of postoperative wound contamination and infection post-appendectomy might be increased with increasing severity of the appendicitis treated, and majority of infections can occur after emergency or perforated appendicitis [11]. during surgery the major risk of occurrence of subsequent wound infection is bacterial contamination during surgical intervention and the incriminated organisms are bacteria from the colon flora [12].…”

mentioning

confidence: 99%

Comparison Between Delayed Primary Closure and Immediate Primary Closure of Abdominal Incisions in Patients With Septic Peritonitis.

Raafat¹,

Habib²,

Sallam³

et al. 2018

IJAR

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Background:It is still a point of controversy if performing delayed primary closure (DPC) of abdominal incisions in cases of abdominal septic operations could be able to reduce incidence of surgical-site infection and its bad long term sequels in comparison with immediate primary closure (PC). The Aim: To compare between delayed primary closure and immediate primary closure of abdominal incisions, in patients with peritonitis that results from septic operations regarding superficial surgical site infection. Patients & Methods:we have carried out such study on 60 patients with septic peritonitis that were collected and operated surgically during 2 years in in Department of General Surgery, Zagazig University Hospital. We have divided our cases into 2 groups; Group (1): cases that are managed by immediate PC of the skin and subcutaneous tissue using polypropylene sutures and insertion of subcutaneous drain. Group (2): included cases that are managed by DPC of the skin and subcutaneous tissue, using polypropylene sutures and without insertion of drain. We have followed all patients for 2 weeks for; infection or dehiscence of the wound and for occurrence of burst abdomen, seroma or sub cutaneous collection. Results: we have detected that DPC is better than immediate PC as regard decreasing incidence of wound infection & dehiscence (p=0,009), less liability for occurrence of burst abdomen (p=0.042), sub cutaneous collection (p=0.003) and seroma (p<0.001). Conclusion: performing DPC will be better than immediate PC in management of patients with septic peritonitis.

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Management of Perforated Appendicitis in Children—Revisited

Samelson¹,

Reyes²

1987

Arch Surg

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The Infective Dose of Aerobic and Anaerobic Bacteria in Postoperative Wound Sepsis

Cited by 72 publications

References 24 publications

Wound Microbiology and Associated Approaches to Wound Management

Wound Microbiology and Associated Approaches to Wound Management

Comparison Between Delayed Primary Closure and Immediate Primary Closure of Abdominal Incisions in Patients With Septic Peritonitis.

Management of Perforated Appendicitis in Children—Revisited

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