The inferior colliculus of the mouse. A Nissl and Golgi study

Meininger, Vincent; Pol, Dilip G; Derer, P

doi:10.1016/0306-4522(86)90085-0

Cited by 118 publications

(68 citation statements)

References 30 publications

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“…The silver-stained sections showed also the arrangement of the nerve fibers in bundles in a dorsomedial direction to periaqueductal grey matter. In accordance with the present results, Meininger et al (1986) found that the fibers of lateral lemniscus which represents the main auditory input to the IC enters it ventrally and divide in two bundles. These two bundles are Uranyl acetate and lead citrate; X10,000 directed dorsomedially to the central nucleus; the fibers of the lateral lemniscus are interspersed with other nerve fibers giving the appearance of a dense meshwork of fibers.…”

Section: Discussionsupporting

confidence: 93%

“…Few were rounded in shape exhibiting no processes. These observations are compatible with the results of Meininger et al (1986) who studied the inferior colliculus in mice and observed that the central nucleus contains two major types: the bipolar cells, which are the most abundant and the multipolar cells. Najdzion et al (2002) also described the neuronal structure of the inferior colliculus in the adult bank vole (the rat of the fields) and found that the central nucleus showed a laminated appearance and observed 5 types of neurons, rounded, fusiform cells which constitute the main neuronal type.…”

Section: Discussionsupporting

confidence: 92%

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Effects of Ageing and Alloxan- Induced Diabetes Mellitus on the Structure of Inferior Colliculus in male Albino Rats: a Light and Electron Microscopic Study

Refaat

2010

The Egyptian Journal of Anatomy

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Background: The inferior colliculus (IC) is an important relay centre in the acoustic pathway that can influence the motor neurons in the brain stem and spinal cord. Aim of the Work: This research was conducted to study the structural changes in the inferior colliculus of the senile and adult diabetic male albino rats compared to the adult control one using both the light and transmission electron microscopy. Material and Methods: A total of 30 male albino rats were divided into 3 equal groups including adult (3 -4 months) and senile (24 months), adult diabetic (3 -4 months) rats. To induce diabetes, a single dose of alloxan (200mg/kg body weight) dissolved in distilled water was injected intraperitoneally. Two months later, the animals of all groups were anaesthetized with ether and sacrificed, followed by removal of the inferior colliculi, which were processed for microscopic examination. Results: The histological examination of the inferior colliculus in adult control rats revealed that the nerve processes were relatively abundant than the neuronal somata. The nerve fibers were myelinated, arranged in clusters, and the majority had thick, uniform and regular myelin sheath. The inferior colliculus was constituted of a superficial cortex and a deep central part. The nerve cells in the cortex were few in number and rounded in shape. In the center, many cells of different sizes which exhibited unipolar, bipolar or multipolar processes were observed. In the senile rats, variable degrees of degeneration were observed in both the nerve cells and fibers. The nerve cells were either appeared swollen or showed small size with dense cytoplasm and dark pyknotic nuclei. The myelinated nerve fibers showed thickened myelin sheaths, disrupted sheaths, separation of their lamellae and sometimes showed shrunken degenerated nerve axon. In diabetic rats, most of the neuronal somata appeared small in size with small, dark and pyknotic nuclei. The neuropil showed extensive vacuolation and congested blood vessels with thickened basement membrane. Thin myelinated and unmyelinated nerve fibers were observed with vacuolated cytoplasmic matrix. Silverstained sections showed irregular-shaped thin nerve fibers. Conclusions: Diabetic state induced severe degenerative changes in the inferior colliculus, which were worse than those detected in the senile rats. Such changes may contribute in hearing loss of the young diabetics. So, the auditory health and early clinical testing of the diabetics are highly important for early prevention of deleterious complications of diabetes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Effects of Ageing and Alloxan- Induced Diabetes Mellitus on the Structure of Inferior Colliculus in male Albino Rats: a Light and Electron Microscopic Study

Refaat

2010

The Egyptian Journal of Anatomy

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“…Support for a functional link between the activation of DA prefrontal neurons and the behavioral responses induced by IC aversive stimulation has been reported recently (Cuadra et al, 2000). Although there are substantial cortical inputs to dorsal midbrain regions, it is established that the IC also projects densely to cortical areas, mainly to the temporal lobe (Cooper and Young, 1976;Fadda et al, 1978;Adams, 1979;Meininger et al, 1986). In fact, the IC is a key pathway for auditory information and disturbances at this level may alter the transmission to cortical centers.…”

Section: Discussionmentioning

confidence: 93%

“…Several studies have suggested modulatory roles for GABA, serotonin, opioids, excitatory amino acids and neuropeptides at the so-called brain aversion system, which includes the dorsal periaqueductal gray and IC (Brandão et al, 1982. The IC is connected to cortical areas (Adams, 1979;Hoffman and Ison, 1980;Meininger et al, 1986;Fuster, 1989;Hoffman Brodal, 1992). One of these pathways is provided by projections from the central nucleus of the IC to the prefrontal cortex through the medial geniculate nucleus, amygdala and dorsomedial thalamus (Fuster, 1989;Brodal, 1992).…”

Section: Introductionmentioning

confidence: 99%

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Troncoso¹,

Osaki²,

Mason³

et al. 2003

Neuropsychopharmacol

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Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus (IC) as unconditioned stimulus (UCS). Recent reports have also demonstrated that aversive stimulation of the IC, at the escape threshold, enhances dopamine (DA) release in the prefrontal cortex. The purpose of the present study was to determine whether dopaminergic mechanisms are involved in the Pavlovian conditioning and latent inhibition using IC stimulation as UCS and light as conditioned stimulus (CS). Rats were placed inside a shuttle box and subjected to a two-way avoidance paradigm. IC aversive electrical stimulation was used as UCS and shuttle box illumination as CS. The rats quickly learned to avoid or interrupt the IC stimulation. Apomorphine injections produced a dose-dependent increase in the number of avoidance responses. On the other hand, chlorpromazine administration promoted a dose-dependent reduction of the avoidance responses. Previous injections of chlorpromazine inhibited the effects of apomorphine. Also, previous exposure to unreinforced light weakened the strength of the conditioning. Apomorphine blocked this latent inhibition effect, which was antagonized by previous injections of chlorpromazine. These findings bring evidence for the involvement of DA in the setting up of adaptive responses to aversive states generated at the IC level, which may underlie stressful situations present in anxiety.

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“…Morphology suggests the central nucleus of the IC should have two types of neurons based on the shape and orientation of the dendritic tree. 9,22,25,33,51 The principal neuron is discshaped (called the¯at neuron in rats) with dendrites that parallel the ®bro-dendritic laminae. A second, less common neuron with a different dendritic morphology is also found in all species studied (e.g.…”

mentioning

confidence: 99%

Identification of cell types in brain slices of the inferior colliculus

2000

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AbstractÐDifferent type neurons in the inferior colliculus may have different functions. Recent intracellular studies of the inferior colliculus suggest that intrinsic electrical properties contribute to discharge patterns, but the intrinsic discharge patterns have not been fully characterized in the central nucleus, the main part of the inferior colliculus. Whether different types of neurons are related to different discharge patterns is unclear.We have used intracellular and whole-cell patch clamp-recording techniques in a brain slice preparation to better characterize discharge patterns and cell types in the central nucleus. Several types of discharge pattern were found in the inferior colliculus in response to long pulses of intracellular depolarizations. Rebound and buildup±pauser discharges, together, comprise neurons with a sustained response and are the majority of the neurons in the inferior colliculus. Both of these types of discharge pattern could be adapting or regular. Onset discharges distinguished another group of neurons. Onset neurons can also entrain to higher frequency stimuli than sustained neurons. Discharge patterns are correlated with distinctive current±voltage relationships and with some aspects of dendritic morphology. However, the morphological data demonstrates that the discharge patterns do not correspond simply to disc-shaped (¯at) or stellate (less-¯at) categories. This is the ®rst extensive analysis of electrophysiological properties of the central nucleus of the inferior colliculus in vitro. We suggest that there may be at least three functional classes of neurons and have implications for signal processing in the inferior colliculus. q 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.Key words: auditory pathways, temporal coding, rat, discharge patterns, neuronal morphology.What are the neuron types in the inferior colliculus (IC), the principal part of the auditory pathway in the midbrain? Morphology suggests the central nucleus of the IC should have two types of neurons based on the shape and orientation of the dendritic tree. 9,22,25,33,51 The principal neuron is discshaped (called the¯at neuron in rats) with dendrites that parallel the ®bro-dendritic laminae. A second, less common neuron with a different dendritic morphology is also found in all species studied (e.g. the less-¯at neuron in the rat).In contrast, physiology suggests three or more cell types are present based on responses to binaural acoustic stimuli and frequency-amplitude maps. 6,13,45 Morphological classi®cation based on dendritic shape or orientation is reconciled with some physiological characteristics and not others. For example, neurons with similar binaural properties often have heterogenous morphology, indicating a lack of correlation, whereas the presence of inhibitory side bands is well correlated with stellate morphology. 18 The discharge patterns in the IC may be a useful method to classify neurons. Onset, sustained, buildup, and pauser discharge patterns are well-documented in man...

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The inferior colliculus of the mouse. A Nissl and Golgi study

Cited by 118 publications

References 30 publications

Effects of Ageing and Alloxan- Induced Diabetes Mellitus on the Structure of Inferior Colliculus in male Albino Rats: a Light and Electron Microscopic Study

Effects of Ageing and Alloxan- Induced Diabetes Mellitus on the Structure of Inferior Colliculus in male Albino Rats: a Light and Electron Microscopic Study

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Identification of cell types in brain slices of the inferior colliculus

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