2011
DOI: 10.1038/cmi.2010.81
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The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond

Abstract: Nucleotide-binding oligomerization domain (NOD)-containing protein-like receptors (NLRs) are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen recognition. Some NLRs form the framework for cytosolic platforms called inflammasomes, which orchestrate the early inflammatory process via IL-1b activation. Mutations and polymorphisms in NLR-coding genes or in genetic loci encoding inflammasome-related proteins correlate with a v… Show more

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Cited by 97 publications
(82 citation statements)
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References 139 publications
(165 reference statements)
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“…Most of the variants are missense substitutions affecting the NACHT domain, encoded by exon 3 (19). In contrast, the DFNA34 mutation affects the LRR domain.…”
Section: Discussionmentioning
confidence: 99%
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“…Most of the variants are missense substitutions affecting the NACHT domain, encoded by exon 3 (19). In contrast, the DFNA34 mutation affects the LRR domain.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, the DFNA34 mutation affects the LRR domain. Mutations in the LRR domain are associated with atypical or milder phenotypes (19). Although the LRRs are believed to maintain NLRP3 in an autosuppressed state (7), the molecular mechanism of mutations leading to atypical phenotypes remains unknown.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent studies have identified a variety of NLRP3 inflammasome activators including whole live bacteria, fungal and viral pathogens, as well as various microbial-associated molecular patterns and DAMPs [2]. In addition, cellular stress triggered by factors ranging from oxidative stress to lysosomal damage appears sufficient to activate NLRP3 [3].…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies have identified a variety of NLRP3 inflammasome activators including whole live bacteria, fungal and viral pathogens, as well as various microbial-associated molecular patterns and DAMPs [2]. In addition, cellular stress triggered by factors ranging from oxidative stress to lysosomal damage appears sufficient to activate NLRP3 [3].The mechanisms by which these molecules of diverse origins and structures can each trigger the NLRP3 inflammasome remain unclear. However, the generation of ROS seems to be a unifying factor, consistently mediating NLRP3 activation across several stimuli [4].…”
mentioning
confidence: 99%