The Inflammatory Marker HSCRP as a Predictor of Increased Insulin Resistance in Type 2 Diabetics without Atherosclerotic Manifestations

Grigorescu, Elena-Daniela; Șorodoc, Victorița; Floria, Mariana; Anisie, Ecaterina; Popa, Alina; Onofriescu, Alina; Ceasovschih, Alexandr; Şorodoc, Laurenţiu

doi:10.37358/rc.19.5.7216

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…Inflammatory marker hsCRP was found to be related to the metabolic profiles and was found to be a good prognostic marker of cardiovascular complications in type 2 diabetic patients without clinical atherosclerotic manifestations by various studies [15,16]. This indicates the significance of hsCRP in predicting cardiovascular complications in otherwise healthy-looking patients with raised blood glucose levels.…”

Section: Discussionmentioning

confidence: 86%

Association of Serum High Sensitivity C-Reactive Protein With Pre-diabetes in Rural Population: A Two-Year Cross-Sectional Study

Ghule¹,

Kamble²,

Talwar³

et al. 2021

Cureus

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Section: Discussionmentioning

confidence: 86%

Association of Serum High Sensitivity C-Reactive Protein With Pre-diabetes in Rural Population: A Two-Year Cross-Sectional Study

Ghule¹,

Kamble²,

Talwar³

et al. 2021

Cureus

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“…Thus, atherosclerosis is a complex chain of events developing in the vascular wall involving many cells, among which endothelial cells are key participants in vascular biology. In addition to the risk factors described above, insulin resistance and diabetes mellitus play an important role in atherogenesis [ 104 ]. It is important to note that NO production can be stimulated by insulin, whereas insulin resistance leads to impaired NO production [ 105 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Atherogenic Factors on Endothelial Cells: Bioinformatics Analysis of Differentially Expressed Genes and Signaling Pathways

Kotlyarov

2023

Biomedicines

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(1) Background: Atherosclerosis is a serious medical condition associated with high morbidity and mortality rates. It develops over many years as a complex chain of events in the vascular wall involving various cells and is influenced by many factors of clinical interest. (2) Methods: In this study, we performed a bioinformatic analysis of Gene Expression Omnibus (GEO) datasets to investigate the gene ontology of differentially expressed genes (DEGs) in endothelial cells exposed to atherogenic factors such as tobacco smoking, oscillatory shear, and oxidized low-density lipoproteins (oxLDL). DEGs were identified using the limma R package, and gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein–protein interaction (PPI) network analysis were performed. (3) Results: We studied biological processes and signaling pathways involving DEGs in endothelial cells under the influence of atherogenic factors. GO enrichment analysis demonstrated that the DEGs were mainly involved in cytokine-mediated signaling pathway, innate immune response, lipid biosynthetic process, 5-lipoxygenase activity, and nitric-oxide synthase activity. KEGG pathway enrichment analysis showed that common pathways included tumor necrosis factor signaling pathway, NF-κB signaling pathway, NOD-like receptor signaling pathway, lipid and atherosclerosis, lipoprotein particle binding, and apoptosis. (4) Conclusions: Atherogenic factors such as smoking, impaired flow, and oxLDL contribute to impaired innate immune response, metabolism, and apoptosis in endothelial cells, potentially leading to the development of atherosclerosis.

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“…As discussed elsewhere, the degree to which our T2DM patients are subject to subtle inflammatory processes is of material clinical interest, given the wide-ranging damage that inflammation exerts on the body The (19) .…”

Section: Original Papersmentioning

confidence: 99%

The Relationship between Hepatic Steatosis, inflammation and insulin Resistance in type 2 Diabetes with Metabolic Imbalance

et al. 2019

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Aim. Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are in a bidirectional relationship. This prospective study focused on associations between parameters common to the pathogenesis of insulin resistance, inflammation and hepatic steatosis in T2DM patients with metabolic imbalance.Methods. We used clinical data, insulin resistance and inflammation indices, and hepatic steatosis markers from 120 patients.Results. The patients (44% men, mean age 58) had a mean body mass index (BMI) of 32 kg/m2 and mean T2DM history of 6 years. With exceptions, significant correlations were found between metabolic, inflammatory and hepatic parameters.Conclusions. In T2DM patients with poor glycemic control, hepatic steatosis correlates significantly with insulin resistance and inflammation. Increased prevalence and poor prognosis of these diseases together justify the need for NAFLD screening of diabetic patients.

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The Inflammatory Marker HSCRP as a Predictor of Increased Insulin Resistance in Type 2 Diabetics without Atherosclerotic Manifestations

Cited by 11 publications

References 19 publications

Association of Serum High Sensitivity C-Reactive Protein With Pre-diabetes in Rural Population: A Two-Year Cross-Sectional Study

Association of Serum High Sensitivity C-Reactive Protein With Pre-diabetes in Rural Population: A Two-Year Cross-Sectional Study

Effects of Atherogenic Factors on Endothelial Cells: Bioinformatics Analysis of Differentially Expressed Genes and Signaling Pathways

The Relationship between Hepatic Steatosis, inflammation and insulin Resistance in type 2 Diabetes with Metabolic Imbalance

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