The Inflammatory Mechanisms of Allograft Rejection

Hsauyry, P.; Willebrand, E von; Parthenais, Elaine; Nemlander, Arto; Soots, Anu; Lautenschlager, Irmeli; Alföldy, P; Renkonen, Risto

doi:10.1111/j.1600-065x.1984.tb00719.x

Cited by 94 publications

(25 citation statements)

References 129 publications

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“…The rejection of rat renal allografts is heralded by the appearance in the graft of monocytes and lymphocytes (4). Large granular lymphocytes are the first morphologically distinct leucocytes to appear.…”

Section: B Leucocytic Infiltration Of Rat Allograftsmentioning

confidence: 99%

“…The data available on the leucocytic infiltrate of human renal allografts is by no means as inclusive or as detailed as for the rat, but there is a consensus among the various reports that cytotoxic/suppressor T cells predominate within acutely rejecting grafts (4,5,6). In some special instances, the pattern of leucocytic infiltration may deviate from the norm, especially during steroid therapy (4,7).…”

Section: Leucocytic Infiltration Of Human Allograftsmentioning

confidence: 99%

“…In some special instances, the pattern of leucocytic infiltration may deviate from the norm, especially during steroid therapy (4,7). Helper cells predominate under those conditions, and may indicate a rejection episode which resists further suppressive therapy.…”

Section: Leucocytic Infiltration Of Human Allograftsmentioning

confidence: 99%

“…Helper cells predominate under those conditions, and may indicate a rejection episode which resists further suppressive therapy. The suggestion has been made that the different patterns of infiltration might signify alternate mechanisms of allograft rejection (4). A further complicating factor is the effect of associated viral infections, especially those caused by Epstein-Barr virus and cytomegalovirus (6).…”

Section: Leucocytic Infiltration Of Human Allograftsmentioning

confidence: 99%

“…For the most part, the methods employed have included tumor dissociation, followed by leucocyte fractionation, identification, and in vitro assays of cytotoxic activity. The significance of leucocytic infiltration has been the subject of two recent monographs (3,4) and the reader is referred to those texts for more detailed coverage of the subjects discussed herein. In this review, we shall confine our discussion to those topics which we feel are problematical or have received inadequate attention in the past.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of tumor leucocytic infiltration to host defense mechanisms and prognosis

1984

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The interface between the tumor and the host is often the site of leucocytic infiltration. We will examine the idea that the infiltrating leucocytes of human and experimental tumors are components of the host immunological defense against the tumor, and that the presence of the infiltrate is a marker of favorable prognosis. Leucocytes could infiltrate tumors because of an active immune response, either nonspecific or specifically directed to tumor-associated antigens. Leucocyte influx may also occur because of chemotactic factors secreted by the tumor cells. Some tumors release factors which enhance vascular permeability and permit improved access by leucocytes to the tumor focus. The consequences of leucocytic infiltration include tumor cell cytolysis, cytostasis, or stimulation of proliferation. The present state of our knowledge of the interactions between tumor cells and infiltrating leucocytes precludes broad generalization of mechanisms. Further study will probably reveal that the mechanisms are diverse, and that there are some systems in which immune interactions occur at this interface and others in which they do not.

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Section: B Leucocytic Infiltration Of Rat Allograftsmentioning

confidence: 99%