The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Paul J. Baker,
Andrea C. Bohrer,
Ehydel Castro
et al.
Abstract:Severity of COVID-19 is affected by multiple factors; however, it is not understood how the inflammatory milieu of the lung at the time of SARS-CoV-2 exposure affects the control of viral replication. Here, we demonstrate that immune events in the mouse lung closely preceding SARS-CoV-2 infection affect viral control and identify innate immune pathways that limit viral replication. Pulmonary inflammatory stimuli including resolved, antecedent respiratory infections with
Staphylococcus aureus
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