The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease

Özsoy, Özlem; Seval-Celik, Yasemin; Hacioglu, Gulay; Yargiçoğlu, Pi̇raye; Demir, Ramazan; Ağar, Ayşel; Aslan, Mutay

doi:10.1016/j.neuint.2011.06.012

Cited by 50 publications

(30 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many reports have shown that treatments based on omega 3 fatty acids exert beneficial effects in various animal models of neurodegenerative disease, such as Parkinson's or Alzheimer's diseases (Arsenault et al, 2011; Ozsoy et al, 2011). In a recent study, Michael-Titus and colleagues investigated the neuroprotective effect of eicosapentaenoic acid, an omega 3 fatty acid precursor for DHA, in SOD1 mice.…”

Section: A Role For Lipids Beside Energetic Metabolismmentioning

confidence: 99%

A plural role for lipids in motor neuron diseases: energy, signaling and structure

Schmitt

Hussain

Dupuis

et al. 2014

Front. Cell. Neurosci.

108

View full text Add to dashboard Cite

Motor neuron diseases (MNDs) are characterized by selective death of motor neurons and include mainly adult-onset amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Neurodegeneration is not the single pathogenic event occurring during disease progression. There are multiple lines of evidence for the existence of defects in lipid metabolism at peripheral level. For instance, hypermetabolism is well characterized in ALS, and dyslipidemia correlates with better prognosis in patients. Lipid metabolism plays also a role in other MNDs. In SMA, misuse of lipids as energetic nutrients is described in patients and in related animal models. The composition of structural lipids in the central nervous system is modified, with repercussion on membrane fluidity and on cell signaling mediated by bioactive lipids. Here, we review the main epidemiologic and mechanistic findings that link alterations of lipid metabolism and motor neuron degeneration, and we discuss the rationale of targeting these modifications for therapeutic management of MNDs.

show abstract

Section: A Role For Lipids Beside Energetic Metabolismmentioning

confidence: 99%

A plural role for lipids in motor neuron diseases: energy, signaling and structure

Schmitt

Hussain

Dupuis

et al. 2014

Front. Cell. Neurosci.

108

View full text Add to dashboard Cite

show abstract

“…DHA protects neurons against cytotoxicity, inhibits nitrogen oxide (NO) production, and calcium (Ca 2+ ) influx. DHA enhances the activities of antioxidant enzymes such as glutathione peroxidase and glutathione reductase and diminishes apoptosis in dopaminergic cells [45] in the brains of mice post-MPTP treatment. Short-term administration of DHA markedly reduced levodopa-induced dyskinesias in parkinsonian primates and caused significant reduction in parkinsonian behaviors and elevated dopamine (DA) levels in 6-OHDA rodents [46].…”

Section: Omega-3 Polyunsaturated Fatty Acids (Pufas)mentioning

confidence: 99%

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

View full text Add to dashboard Cite

Various nutritional components belonging to different classes of natural dietary origin display modulatory (protective) properties against age-related neurodegenerative disorders (NDD) such as Parkinson's disease (PD) and Alzheimer's disease. These compounds termed as nutraceuticals which have been shown to act at various biochemical and metabolic levels and exhibit different degree of neuroprotective properties. Present review aims to summarize the current status on the modulatory impact of some of the major nutritional compounds on the pathophysiology of PD, the second most common NDD in humans. Primarily, we have examined the data demonstrated in animal models and postulated through epidemiological studies on the compounds/molecules/life style factors which reduce the risk associated with PD and probable mechanism/s through which they elicit neuroprotection. Further we also included some of the conflicting information about the compounds which may enhance the risk associated with PD. Additionally, emphasis is also given about the new approaches to understand the impact of nutrition on the epigenome in relation to the development of NDD with a short note on emerging ideas relating to nutritional genomics.

show abstract

“…It may also have a benefit to PD animal models. Animals with MPTP-induced impaired balance and motor coordination showed diminished Parkinsonism symptoms and decreased dopaminergic neuronal death when fed a DHA diet (Ozsoy et al, 2011) DHA and EPA improve memory performance in mild AD (Scheltens et al, 2012;Yehuda et al, 1996) …”

Section: Small Molecules That Promote Protein Refoldingmentioning

confidence: 99%

“…Animals dosed with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-exhibited impaired balance and motor coordination, but diminished parkinsonism symptoms and decreased dopaminergic neuronal death when fed a DHA diet (Ozsoy et al, 2011). DHA supplementation may protect dopaminergic neurons in experimental PD models by targeting inflammatory signaling pathways and enhancing the expression of GDNF and Neurturin (member of the same protein family as glial cell-derived neurotrophic factor), which has been shown to benefit the dopaminergic neurons in the substantia nigra which is affected in PD (Bousquet et al, 2011;Cardoso et al, 2012;Hacioglu et al, 2012;Ji et al, 2012;Ozsoy et al, 2011;Tanriover et al, 2010). DHA supplementation in a nonhuman primate MPTP model reduces levodopa-induced dyskinesia, suggesting a safe and innovative therapy for improving the life quality of PD patients (Mahmoudi et al, 2009).…”

Section: Proteasome Activatorsmentioning

confidence: 99%

Toward therapeutic targets for SCA3: Insight into the role of Machado–Joseph disease protein ataxin-3 in misfolded proteins clearance

Fischhaber

et al. 2015

Progress in Neurobiology

View full text Add to dashboard Cite

The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease

Cited by 50 publications

References 86 publications

A plural role for lipids in motor neuron diseases: energy, signaling and structure

A plural role for lipids in motor neuron diseases: energy, signaling and structure

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Toward therapeutic targets for SCA3: Insight into the role of Machado–Joseph disease protein ataxin-3 in misfolded proteins clearance

Contact Info

Product

Resources

About