The influence of 5-hydroxytryptamine on the actions of adrenaline

Uppal, R; Dutta, Sharmistha; Sanyal, R. K.

doi:10.1111/j.2042-7158.1967.tb09589.x

Cited by 2 publications

(2 citation statements)

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“…Hurwitz et al (1961) studied vasoconstrictor responses in the dog and concluded that serotonin antagonized the vasoconstrictor action of catecholamines in the small vessels of the hindlimbs. Conversely, Uppal, Dutta & Sanyal (1967) reported that the actions of serotonin and adrenaline on the systemic blood pressure of rabbits and dogs were additive. Jester & Horst (1972) have shown that different concentrations of serotonin inhibit either the neuronal uptake or storage of catecholamines in isolated perfused rat hearts, and may also block adrenoceptors.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Serotonin Precursors on the Pressor Response to Intravenous Clonidine in Conscious Rats

Nolan

1977

Clin Exp Pharma Physio

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1. The interaction of the biosynthetic precursors of serotonin with the alpha-adrenoceptor-mediated pressor response to intravenous clonidine was investigated in unanaesthetized rats. 2. Pretreatment with 100 mg/kg of either L-tryptophan or 5-hydroxytryptophan (5-HTP) reduced the magnitude of the pressor response elicited by intravenous clonidine (25 microgram/kg) to 15% and 11%, respectively, of that observed in control rats. 3. The depression by L-tryptophan of the clonidine-induced pressor response could be prevented by pretreatment with either the L-aromatic amino acid decarboxylase inhibitor Rö44602 or the serotonin antagonist methysergide.

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Section: Discussionmentioning

confidence: 99%

The Effects of Serotonin Precursors on the Pressor Response to Intravenous Clonidine in Conscious Rats

Nolan

1977

Clin Exp Pharma Physio

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“…It has been reported that 5-Hydroxytryptamine antagonizes certain toxic actions of adrenaline [9], The effect of simultaneous administration of 5-HT along with adrenaline in animals sensitized with chloroform was also assessed.…”

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confidence: 99%