The influence of acetaminophen on sprint interval treadmill running

Park, Laura L.; Baker, Catherine E; Sum, Alvin; Hayes, Lawrence D.

doi:10.26582/k.48.1.11

Cited by 7 publications

(18 citation statements)

References 19 publications

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“…There are studies attempting which attempt to evaluate the impact of this substance on sporting performance. For instance, Park et al (2016) confirms the reduction of the perceived sense of pain during load implementation by 8-15%. Foster et al (2014) demonstrated that paracetamol may have improved performance through the reduction of pain for a given work rate, and another study also shows a significant increase in the observed values of maximum performance (Strava & Rusu, 2015).…”

Section: Introductionsupporting

confidence: 52%

“…Its effects, which are likely to impact sporting performance, especially by suppressing the perceived pain, mean that the results from numerous studies evaluating these effects are followed with great interest by the entire sports community. Some studies have demonstrated its favourable impact on performance (Park et al, 2016, Strava & Rusu, 2015, while others have not confirmed such an effect (Delextrat et al, 2015, Mauger et al, 2010. At the same time, it should be remembered that if the studies show improvement of sport performance (Park et al, 2016, Strava & Rusu, 2015, they involve a quantity with adverse effect on the athlete's health (Hodis, 2015, Blieden et al, 2014.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have demonstrated its favourable impact on performance (Park et al, 2016, Strava & Rusu, 2015, while others have not confirmed such an effect (Delextrat et al, 2015, Mauger et al, 2010. At the same time, it should be remembered that if the studies show improvement of sport performance (Park et al, 2016, Strava & Rusu, 2015, they involve a quantity with adverse effect on the athlete's health (Hodis, 2015, Blieden et al, 2014. This is why we decided to evaluate the effect of the "medically still acceptable dose" of paracetamol, reinforcing its analgesic effect by adding ASA.…”

Section: Discussionmentioning

confidence: 99%

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2017

JPES

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Pain reduction can be a significant factor favourably influencing sporting performance. The article is principally focused on evaluating the effects of a combination of analgesics, namely paracetamol and acetylsalicylic acid, on maximum performance and on the perception of load intensity. In a set of healthy athletes (n = 16, mean age = 32.6), who underwent two standardized Wingate Anaerobic tests with and without the indication of the selected analgesics, we ascertained no significant differences in any of the observed parameters of anaerobic performance nor in any other data observed.

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Section: Introductionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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2017

JPES

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“…This non-improvement in exercise performance after acetaminophen ingestion in the present study conflicts with previous observations that acetaminophen ingestion (1.5 g) improves exercise performance during a 16.1-km cycling TT [9], increases total work done during a 3-min all-out test [36], increases time to task failure at 70% V̇O 2 max (8), raises the peak or mean power output during repeated sprints [7,19], and increases mean torque during a 60 x 3-s MVC (2-s passive recovery period) protocol [37]. On the other hand, other studies failed to find an effect of acetaminophen ingestion on time to task failure at 70% V̇O 2 max [17] or repeated sprint performance [18]. The reason for these contradictory results is not clear, but it may be related to different exercise protocols and tasks measuring exercise performance.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism by which acetaminophen reliefs pain feelings in humans is not fully known, but it has been attributed to the inhibition of the cyclooxygenase enzymes [10–13], potentiation of descending serotoninergic pathways [14,15], and modulation of opioid and cannabinoid CB1 receptors [11,16]. Although there is not a consensus [17,18], several studies have reported improved performance during high-intensity exercises after a single clinical dose (1-1.5 g or 20 mg·kg −1 ) of acetaminophen [7–9,19].…”

Section: Introductionmentioning

confidence: 99%

Caffeine but not acetaminophen increases 4-km cycling time-trial performance

Lima‐Silva

Tomazini

Mariano

et al. 2019

Preprint

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27Acetaminophen has been combined with caffeine for therapeutic purpose, but the effect 28 of co-ingestion of acetaminophen and caffeine on exercise performance has not been 29 investigated. The aim of this study was to determine the effect of isolated and combined 30 ingestion of caffeine and acetaminophen on performance during a 4-km cycling time-trial. In a 31 double-blind, crossover design, eleven men, accustomed to cycling recreationally, completed a 32 4-km cycling time-trial one hour after the ingestion of cellulose (PLA), acetaminophen (20 33 mg . kg -1 body mass, ACT), caffeine (5 mg . kg -1 body mass, CAF) or combined acetaminophen 34 and caffeine (20 and 5 mg . kg -1 body mass, respectively, ACTCAF). The perception of pain and 35 rating of perceived exertion were recorded every 1-km, and electromyography and oxygen 36 uptake were continually recorded and averaged each 1-km. Plasma lactate concentration was 37 measured before and immediately after the trial. The time and mean power during the 4-km 38 cycling time-trial was significantly improved (P < 0.05) in CAF (407.9 ± 24.5 s, 241.4 ± 16.1 39 W) compared to PLA (416.1 ± 34.1 s, 234.1 ± 19.2 W) and ACT (416.2 ± 26.6 s, 235.8 ± 19.7 40 W). However, there was no difference between ACTCAF (411.6 ± 27.7 s, 238.7 ± 18.7 W) and 41 the other conditions (P > 0.05). The perception of pain, rating of perceived exertion, 42 electromyography, oxygen uptake, and plasma lactate were similar across the conditions (P > 43 0.05). In conclusion, caffeine but not acetaminophen increases power output ultimately 44 increasing performance during a 4-km cycling time-trial. 45 46 47 48 49 50 51 52 53 3 54 Introduction 55 56During a self-paced, high-intensity cycling time-trial (e.g., 4-km cycling TT), the 57 exercise intensity must be strictly regulated to avoid an exacerbated early accumulation of 58 metabolites that can lead to fatigue [1][2][3]. A disturbance in the intramuscular metabolic milieu 59 (i.e., accumulation of the H + , ADP, AMP and Pi) at the beginning of a high-intensity cycling 60 TT, provoked by increased muscle recruitment (as inferred from electromyography signals, 61 EMG) ultimately increasing power output (PO) [2,3], will activate peripheral sensory nerve 62 terminals [4,5]. These increased afferent signals might result in increased perception of pain 63 [6], leading to a reduction in PO [2,3]. 64 65Acetaminophen (commonly known as paracetamol) has recently been introduced as a 66 potential pharmacological agent to increase exercise performance due to its analgesic 67 proprieties [7-9]. The mechanism by which acetaminophen reliefs pain feelings in humans is 68 not fully known, but it has been attributed to the inhibition of the cyclooxygenase enzymes [10-69 13], potentiation of descending serotoninergic pathways [14,15], and modulation of opioid and 70 cannabinoid CB 1 receptors [11,16]. Although there is not a consensus [17,18], several studies 71 have reported improved performance during high-intensity exercises after a single clinical dose 72(1-1.5 ...

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Acute ingestion of acetaminophen improves cognitive and repeated high intensity short-term maximal performance in well-trained female athletes: a randomized placebo-controlled trial

BenSalem,

Salem,

Boukhris

et al. 2024

Eur J Appl Physiol

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This study examined the effect of acute acetaminophen (ACTP) ingestion on physical performance during the 5 m shuttle run test (5mSRT), attention, mood states, and the perception of perceived exertion (RPE), pain (PP), recovery (PRS), and delayed onset of muscle soreness (DOMS) in well-trained female athletes. In a randomized, placebo-controlled, double-blind, crossover trial, fifteen well-trained female athletes (age 21 ± 2 years, height 165 ± 6 cm, body mass 62 ± 5 kg) swallowed either 1.5 g of ACTP or 1.5 g of placebo. The profile of mood states (POMS) and digit cancellation (DCT) were assessed 45 min postingestion, and 5mSRT was performed 60 min postingestion. The RPE and PP were determined immediately after each 30-s repetition of the 5mSRT, and the PRS and DOMS were recorded at 5 min and 24 h post-5mSRT. For the 5mSRT, ACTP ingestion improved the greatest distance (+ 10.88%, p < 0.001), total distance (+ 11.33%, p = 0.0007) and fatigue index (+ 21.43%, p = 0.0003) compared to PLA. Likewise, the DCT score was better on the ACTP (p = 0.0007) than on the PLA. RPE, PP, PRS, and DOMS scores were improved after ACTP ingestion (p < 0.01 for all comparisons) compared to PLA. POMS scores were enhanced with ACTP ingestion compared to PLA (p < 0.01). In conclusion, this study indicates that acute acetaminophen ingestion can improve repeated high intensity short-term maximal performance, attention, mood states, and perceptions of exertion, pain, recovery, and muscle soreness in well-trained female athletes, suggesting potential benefits for their overall athletic performance and mood state.

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The influence of acetaminophen on sprint interval treadmill running

Cited by 7 publications

References 19 publications

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Caffeine but not acetaminophen increases 4-km cycling time-trial performance

Acute ingestion of acetaminophen improves cognitive and repeated high intensity short-term maximal performance in well-trained female athletes: a randomized placebo-controlled trial

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