The Influence of Acidity Function and Water Concentration on the Rate of Hydrolysis of p-Nitrobenzophenone Diethylketal in Aqueous Ethanol

Application Of The H0 Acidity Function To Kinetics And Mechanisms Of Acid Catalysis

“…Somewhat similar results have been obtained by Kaeding and Andrews (3,133) for the hydrolysis of benzophenone diethylketal and its p-nitro derivative. The rate of the latter for 0.1 M hydrochloric acid goes through a minimum with changing ethanol concentration at about 80 mole per cent ethanol, but it increases much less rapidly than ha with increase in the ethanol concentration beyond that point.…”

Concerning the Mechanism of Acid-Catalyzed Hydrolysis of Ketals, Ortho Esters, and Orthocarbonates1

“…5 Kaeding and Andrews, in a study of the hydrolysis of the dimethyl ketal of p-nitrobenzophenone, have obtained results consistent with either a unimolecular or bimolecular reaction path, the latter alternative being favored by these authors. 20 This study was carried out in largely alcoholic media in which reaction of the carbonium ion with solvent would be expected to be rate determining and, hence, provides no evidence for the nature of the reaction pathway in aqueous solution.…”