1963
DOI: 10.1113/jphysiol.1963.sp007254
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The influence of acute sympathetic denervation, reserpine and choline xylyl ether on vagal escape

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Cited by 12 publications
(6 citation statements)
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“…All these findings suggest that a mechanism of this sort might be involved, in the absence of atropine, in the phenomenon of vagal escape. Evidence in favour of this assumption has been presented previously (Friedman & Campos, 1960;Roberts & Stadter, 1960;Campos & Friedman, 1963). In the present work it is shown that cocaine significantly enhances the recovery of the heart from the inhibitory action of the vagus, which is in agreement with recent findings by Moore (1967) in the open-chest dog.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…All these findings suggest that a mechanism of this sort might be involved, in the absence of atropine, in the phenomenon of vagal escape. Evidence in favour of this assumption has been presented previously (Friedman & Campos, 1960;Roberts & Stadter, 1960;Campos & Friedman, 1963). In the present work it is shown that cocaine significantly enhances the recovery of the heart from the inhibitory action of the vagus, which is in agreement with recent findings by Moore (1967) in the open-chest dog.…”
Section: Discussionsupporting
confidence: 93%
“…Conversely a retardation of the escape pattern was indicated by a decrease in this value in comparison with the control. In order to facilitate comparison of the effects of treatments, means of the final cumulative percentage values were expressed as percentages of untreated control group values (Campos & Friedman. 1963).…”
Section: Introductionmentioning
confidence: 99%
“…At the organ level, excess vagal nerve stimulation eventually causes cardiac asystole, followed by resumption of the heartbeat. This desensitization is called vagal escape and has been explained by compensation from the sympathetic system (17)(18)(19)(20). Although ACh causes short-term desensitization of I KACh and vagal escape, the functional relevance of these two different phenomena has not been previously examined.…”
Section: Introductionmentioning
confidence: 99%
“…The latter is commonly referred to as " vagal escape " (Bard, 1956a). Although the mechanism of the escape phenomenon is unresolved, evidence has accumulated which indicates that adrenergic factors may be involved, possibly through a local release of catecholamines by acetylcholine (Campos & Freidman, 1963;Moore, 1967).To evaluate the local release hypothesis, the effects of beta adrenergic and postganglionic parasympathetic blockade on the chronotropic action of the vagus were determined in this study. In the course of our experiments, interesting data were obtained on the effect of stimulation frequency on the duration of vagally induced cardiac asystole and the intracardiac origin of the ensuing vagal escape.…”
mentioning
confidence: 99%
“…The latter is commonly referred to as " vagal escape " (Bard, 1956a). Although the mechanism of the escape phenomenon is unresolved, evidence has accumulated which indicates that adrenergic factors may be involved, possibly through a local release of catecholamines by acetylcholine (Campos & Freidman, 1963;Moore, 1967).…”
mentioning
confidence: 99%