The influence of adult handling and social isolation on dark preference in albino rats

Aulich, D.; Spielhofen, Jürgen; Raaijmakers, Wijnand

doi:10.1016/0003-3472(74)90022-0

Cited by 14 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with the previously reported stress buffering effects of gentle handling and tactile stimulation (Aulich et al., 1974; Costa et al., 2020), another group of rats exposed to the same CMS protocol but which received 10 min of gentle, CLTM optimal velocity (5 cm/s), head to tail stroking on their dorsum immediately prior to the daily stressor showed fewer physiological and behavioral markers of chronic distress. That is, while in Experiment 1, they still had significantly lower body weights than non‐stressed rats, they did not show a significant elevation in corticosterone levels 15 min after the acute forced swim test.…”

Section: Discussionsupporting

confidence: 84%

“…Chronic unpredictable mild stress (CMS) protocols have been developed as validated rodent models for inducing anhedonia and disruptions of HPA function (Castro et al., 2012; Cerqueira, Mailliet, Almeida, Jay, & Sousa, 2007; Moreau, 1997; Ortiz & Conrad, 2018). Experimentally, tactile stimulation, in the form of handling, has previously been reported to decrease behavioral and endocrine markers of chronically stressed rats (Aulich, Spielhofen, & Raaijmakers, 1974; Costa et al., 2020). The aim of thisstudy was to test the hypothesis that CLTMs play a functional role in the physiological regulation of the body's responses to stressors and that stroking at CLTM optimal velocity (5 cm/s), but not faster non CLTM optimal (30 cm/s) strokes, will buffer rat's neuroendocrine and behavioral responses to CMS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

C‐low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress

Walker

Cavieres

Peñaloza‐Sancho

et al. 2020

Eur J of Neuroscience

View full text Add to dashboard Cite

Affiliative tactile interactions buffer social mammals against neurobiological and behavioral effects of stress. The aim of the present study was to investigate the cutaneous mechanisms underlying such beneficial consequences of touch by determining whether daily stroking, specifically targeted to activate a velocity/force tuned class of low-threshold c-fiber mechanoreceptor (CLTM), confers resilience against established markers of chronic unpredictable mild stress (CMS). Adult male Sprague Dawley rats were exposed to two weeks of CMS. Throughout the CMS protocol, some rats were stroked daily, either at CLTM optimal velocity (5cm/s) or outside the CLTM optimal range (30cm/s). A third CMS exposed group did not receive any tactile stimulation. The effect of CMS on serum corticosterone levels, anxiety-and depressive-like behaviors in these three groups was assessed in comparison to a control group of non-CMS exposed rats. While stroking did not mitigate the effects of CMS on body weight gain, CLTM optimal velocity stroking did significantly reduce CMS induced elevations in corticosterone following an acute forced-swim. Rats receiving CLTM optimal stroking also showed significantly fewer anxiety-like behaviors (elevated plus-maze) than the other CMS exposed rats. In terms of depressive-like behavior, while the same velocity specific resilience was observed in a forced-swim test (FST) and social interaction test both groups of stroked rats spent significantly less time interacting than control rats, though they also spent significantly less time in the corner than non-stroked CMS rats. Together, these findings support the theory CLTMs play a functional role in regulating the physiological condition of the body.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

C‐low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress

Walker

Cavieres

Peñaloza‐Sancho

et al. 2020

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Their total number of entries and number of entries into the closed arms, however, were not significantly different, lending support to the hypothesis of an anxiolytic effect. This effect probably resulted from the routine handling necessarily involved in the injection procedure, a factor known to lead to reduced anxiety as measured in the elevated plus-maze and other anxiety paradigms (44,45).…”

Section: Discussionmentioning

confidence: 99%

Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

Silva

Alves

Santarem

1999

Braz J Med Biol Res

View full text Add to dashboard Cite

The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely prescribed for depression and anxiety-related disorders. On the other hand, enhanced serotonergic transmission is known to be classically related to anxiety. In this study, the effects of acute (5.0 mg/kg) and chronic (5.0 mg/kg, 22 days) FLX were investigated in both fooddeprived and non-deprived rats tested in the elevated plus-maze. Significant main effects of the three factors (drug, food condition and administration regimen) were observed, but no interaction between them. The administration of either acute or chronic FLX resulted in an anxiogenic effect, as detected by a significant reduction in the percentage of time spent in the open arms and in the percentage of open arm entries. Food deprivation yielded an anxiolytic-like profile, probably related to changes in locomotor activity. The administration regimen resulted in an anxiolytic profile in chronically treated rats, as would be expected after 22 days of regular handling. The anxiogenic action of acute FLX is consistent with both its neurochemical and clinical profile. The discrepancy between the anxiogenic profile of chronic FLX and its therapeutic uses is discussed in terms of possible differences between the type of anxiety that is measured in the plus-maze and the types of human anxiety that are alleviated by fluoxetine.

show abstract

“…Improvements in learning and memory, including spatial memory impairments caused by neurodegeneration, and decreases in anxiety levels have been reported ( Costa et al, 2012 , Stara et al, 2018 ). Of note, handling for 7 days, 5 min per day in 60-days-old Wistar rats reduced time spent in the dark box as a measure of anxiety in the light-dark choice test ( Aulich et al, 1974 ).…”

Section: Effects Of Early-life Factors On Absence Seizures and Comorb...mentioning

confidence: 99%

The influence of adult handling and social isolation on dark preference in albino rats

Cited by 14 publications

References 15 publications

C‐low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress

C‐low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress

Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

Contact Info

Product

Resources

About