The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

Xia, Houjun; Zhang, Gao-Hong; Wang, Ruirui; Zheng, Yong‐Tang

doi:10.1038/cmi.2009.55

Cited by 53 publications

(48 citation statements)

References 35 publications

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“…Recently, persistent immune activation, which is described as elevated T-lymphocyte turnover and apoptosis; polyclonal B-cell activation; increased NK-cell activation and turnover; and dendritic cell activation, 7,14,15 was found to be a hallmark of HIV infection. In fact, it is well associated with CD4 1 T cell counts and HIV viral loads.…”

Section: Discussionmentioning

confidence: 99%

“…The methods used for flow cytometry analysis of the dendritic cells and T cell subsets have been previously described. 13,14 Briefly, 50-ml whole blood samples were used in each analysis. After incubating blood samples with antibodies (Anti HLA-DR, CD123 antibodies for pDC while anti CD3, CD4 and CD8 antibodies for T cells) in the dark for 15 min, samples were treated with FACS lysing solution (BD Biosciences, San Jose, California, United States) for 10 min at room temperature.…”

Section: Flow Cytometrymentioning

confidence: 99%

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Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques

Xia

Zhang

et al. 2012

Cell Mol Immunol

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It is currently widely accepted that immune activation in HIV-infected individuals leads to a severe loss of CD4 1 T cells and the progression to AIDS. However, the underlying mechanism of this immune activation remains unclear. Experimental data suggest that the activation of plasmacytoid dendritic cells (pDCs) by plasma viremia may play a critical role in HIV-induced immune activation. In this study, we found that the level of immune activation was higher in the late phase of SIVmac239 infection compared with chronic infection, which suggests that immune activation might be related to disease progression in SIVmac239-infected non-human primate models. Our work also showed that chloroquine could effectively inhibit the activation of pDCs in vitro and in vivo. However, chloroquine treatment of SIVmac239-infected macaques had no significant influence on the Cellular composition of peripheral blood in these animals.

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Section: Discussionmentioning

confidence: 99%

Section: Flow Cytometrymentioning

confidence: 99%

Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques

Xia

Zhang

et al. 2012

Cell Mol Immunol

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“…Dysregulation of the adaptive immune response is responsible for the generation of autoimmunity. Females have higher levels of circulating CD4þ T lymphocytes [53,55,56] as well as elevated levels of CD4þ T lymphocytes in the peritoneal cavity [52]. Evidence suggests that the activation of the CD4þ lymphocyte compartment differs between males and females.…”

Section: Sex Differences In Adaptive Immunitymentioning

confidence: 97%

Sex affects immunity

Pennell

Galligan

Fish

2012

Journal of Autoimmunity

362

298

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“…Among the total population diagnosed with an autoimmune disease, almost 80% are female (Libert et al, 2010). Females exhibit greater toll-like receptor expression (Klein et al, 2010) and an increase in number and function of monocytes, macrophages, and dendritic cells than males (Boissier et al, 2003; Xia et al, 2009; Melgert et al, 2010). Additionally, antigen-presenting cells from females present peptides better than the same cells from males (Weinstein et al, 1984).…”

Section: Immune Cells Have Sex Differencesmentioning

confidence: 99%

Sex differences in the immune response to experimental stroke: Implications for translational research

Dotson

Offner

2016

J of Neuroscience Research

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Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than males and, therefore, have a worse stroke outcome. There are also major differences in how the sexes respond to stroke at the cellular level. Immune response is a critical factor in determining the progress of neurodegeneration after stroke and is fundamentally different for males and females. Additionally, females respond to stroke therapies differently from males, yet they are often left out of the basic research that is focused on developing those therapies. With a resounding failure to translate stroke therapies from the bench to the bedside, it is clearer than ever that inclusion of both sexes in stroke studies is essential for future clinical success. This Mini-Review examines sex differences in the immune response to experimental stroke and its implications for therapy development.

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The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

Cited by 53 publications

References 35 publications

Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques

Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques

Sex affects immunity

Sex differences in the immune response to experimental stroke: Implications for translational research

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