The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors

Young, Douglas; Skibiński, Grzegorz; Mason, J. Ian; James, Keith

doi:10.1046/j.1365-2249.1999.01003.x

Cited by 103 publications

(75 citation statements)

References 43 publications

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“…Cortisol in women using OAC was much higher than the other groups, which could be attributed to an elevated concentration of CBG induced by estrogens (39,40). The lower DHEAS concentrations in women than in men, and still lower concentrations in women using OAC, can be explained by the increased metabolic clearance induced by estrogens (41,42). This observation is supported by a randomized controlled trial in which introduction of OAC lowered adrenal androgen concentrations substantially (43).…”

Section: Discussionmentioning

confidence: 79%

Growth-restricted preterm newborns are predisposed to functional adrenal hyperandrogenism in adult life

Meuwese¹,

Euser²,

Ballieux

et al. 2010

European Journal of Endocrinology

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Background: The long-term effects of perinatal growth and corticosteroid exposure on adrenal steroid concentrations in adults born very preterm are uncertain. Objectives: To examine the effect of birth weight, early postnatal growth, and pre-and postnatal corticosteroid administration on serum adrenal steroids in 19-year-old subjects born very preterm. Design and methods: Subjects born before 32 weeks of gestation in The Netherlands participating in the Project on Preterm and Small for Gestational Age Infants (POPS) were investigated at 19 years of age. Serum cortisol, DHEA sulfate (DHEAS), and androstenedione (Adione) concentrations were measured in 393 out of 676 eligible subjects, compared with controls, and associated with perinatal growth and pre-and postnatal corticosteroids administration using multiple linear regression analyses. Results: Serum DHEAS and Adione in men and women were higher than in controls. In the multiple regression analyses, birth weight SDS showed a statistically significant negative association with serum DHEAS concentrations in women (b: K0.865, 95% confidence interval (CI): K1.254 to K0.476) and in men (b: K0.758, 95% CI: K1.247 to K0.268) and with serum Adione concentrations in women (b: K0.337, 95% CI: K0.593 to K0.082). Early postnatal weight gain showed no association with any of measured adrenal markers. In women, serum Adione was associated with postnatal dexamethasone exposure (b: 0.932, 95% CI: 0.022 -1.843). Conclusions: Young adults born very preterm show elevated adrenal androgens, particularly when born small for gestational age. Postnatal corticosteroid administration is positively associated with serum Adione in young women.

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Section: Discussionmentioning

confidence: 79%

Growth-restricted preterm newborns are predisposed to functional adrenal hyperandrogenism in adult life

Meuwese¹,

Euser²,

Ballieux

et al. 2010

European Journal of Endocrinology

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“…We found no relationship between age and the increased bronchial responsiveness to methacholine after exposure in a swine confinement building. The postexposure IL-6 serum levels seemed to increase rather than decrease with age (26) and therefore indicated that the lower increase in serum IL-6 levels after the exposure of the swine farmers (who were older than the nonfarmers) was due to their exposure history rather than to the different age distribution of the groups. In addition, in a study by Bruunsgaard et al (27), it was shown that ex vivo stimulation of blood with LPS resulted in significantly lower levels of TNFα and IL-1β in elderly humans when they were compared with young referents, whereas no difference was detected with regard to IL-6.…”

Section: Palmberg Et Almentioning

confidence: 94%

Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building

Palmberg¹,

Larssson²,

Malmberg³

et al. 2002

Scand J Work Environ Health

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“…[30][31][32][33][34] Women, on the other hand, tend to exhibit higher risk than men in CRP (a marker of inflammation) levels and biomarkers representing neuroendocrine functioning. 30,[35][36][37] Other research has also shown gender differences in cumulative biological risk, with some studies showing men with higher overall levels 15,30 and other studies showing women across different populations with higher levels. 38,39 These combined findings suggest differential patterns of biological risk between men and women and warrant further examination of composite biological risk measures using gender-specific cutoffpoints.…”

Section: Introductionmentioning

confidence: 99%

Racial and Ethnic Patterns of Allostatic Load Among Adult Women in the United States: Findings from the National Health and Nutrition Examination Survey 1999–2004

Chyu

Upchurch

2011

Journal of Women's Health

122

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Objective: This study provides a descriptive sociodemographic profile of allostatic load (AL) among adult women of all age groups, focusing on how age patterns of AL vary across racial/ethnic groups. Allostatic load, an index of cumulative physiological dysregulation, captures how the cumulative impact of physiological stress responses from person-environment interactions causes wear and tear on the body's regulatory systems, which in turn can lead to disease outcomes and health disparities. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004, this study examines AL in a nationally representative sample of women ‡ 18 years of age (n = 5765). Measures of AL using 10 biomarkers representing cardiovascular, inflammatory, and metabolic system functioning were created. Multivariate negative binomial regression models were used, and predicted AL scores were computed. Results: Black women had the highest predicted AL scores relative to other racial/ethnic groups, and a marked black/white gap in AL persisted across all age groups. Age by race/ethnicity interaction terms revealed significant racial/ethnic differences in AL patterns across age groups. Black women 40-49 years old had AL scores 1.14 times higher than white women 50-59 years old, suggesting earlier health deterioration. Mexican women not born in the United States had lower predicted AL scores than those born in the United States. Conclusions: This study provides one of the first descriptive profiles of AL among a nationally representative sample of adult women in the United States and presents racial/ethnic trends in AL across age groups that are useful for identifying demographically and clinically important subgroups at risk of having high cumulative physiological dysregulation.

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The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors

Cited by 103 publications

References 43 publications

Growth-restricted preterm newborns are predisposed to functional adrenal hyperandrogenism in adult life

Growth-restricted preterm newborns are predisposed to functional adrenal hyperandrogenism in adult life

Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building

Racial and Ethnic Patterns of Allostatic Load Among Adult Women in the United States: Findings from the National Health and Nutrition Examination Survey 1999–2004

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