The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study

Prediction of drug absorption based on immobilized artificial membrane (IAM) chromatography separation and calculated molecular descriptors

“…Cell membrane transport of ␤-lactam antibiotic is dose dependent [26]. Compared with the young volunteers, mean plasma concentrations of triamterene, hydrochlortiazide [27] are significantly higher in elderly patients. While plasma concentrations of these drugs are increased in correlation to age of subjects and duration of therapy, urine flow and renal Na + excretion are decreased at the same degree.…”