The influence of age on the activity of acetylsalicylic acid-esterase and protein-salicylate binding

Windorfer, A; Kuenzer, W; Urbanek, R.

doi:10.1007/bf00560385

Cited by 60 publications

(27 citation statements)

References 17 publications

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“…It is possible that salicylate derived from ASA differs in its disposition to that of administered salicylate, and that sex differences may emerge only after oral administration of aspirin. The higher ASA plasma concentrations in females are most likely due to an intrinsically lower concentration of aspirin esterase in female blood as suggested by Menguy et al (1972) and Windorfer et al (1974).…”

Section: Discussionmentioning

confidence: 87%

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

Ho¹,

Triggs²,

Bourne³

et al. 1985

Brit J Clinical Pharma

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The disposition of a low dose (600 mg) of acetylsalicylic acid (ASA) and its metabolites (salicylate, salicyluric acid and salicyl glucuronides) was studied in 25 male and female patients of different ages. Plasma levels of ASA and salicylate were found to be significantly higher in the females (young and elderly), whereas plasma levels of salicyluric acid were found to be significantly higher in the elderly (male and female) groups. The higher plasma levels of ASA and salicylate in the females appear to be due to an intrinsically lower metabolic activity in that sex, while the lower clearance of salicyluric acid leads to the accumulation of that compound in the aged. No age and sex effects were found to influence the volumes of distribution of ASA, salicylate and salicyluric acid.

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Section: Discussionmentioning

confidence: 87%

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

Ho¹,

Triggs²,

Bourne³

et al. 1985

Brit J Clinical Pharma

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“…It has further been shown that the protein-binding of many substances is much less in newborns than in older children or adults [5,8,9,12,14,15,18,29,32]. This is true of endogenous compounds such as bilirubin [34] and of exogenous substances, such as drugs.…”

Section: Zusammenfassung Die Wirkung Eines Medikamentes Ist Unter Anmentioning

confidence: 99%

Investigations on salicylate protein binding in newborns and infants

et al. 1978

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Abstract. The non protein-bound portion of a drug is mainly responsible for the effect of a drug. If this free portion is changed for any reason, drug reactions varying from the normal may occur. Using sodium salicylate as an example, we have investigated this question in newborn children and in infants. It was shown that the newborns had significantly less salicylate protein-binding than the infants had. There was no significant difference of the binding constants between newborns with and without jaundice. In the 75 infants examined, 12 (15%) showed a significant reduction in salicylate protein-binding, but no definite relation to a specific disease could be established. A primary reduction in protein-binding, as well as a secondary reduction because of the disease, must be considered in these children.The importance of this reduced protein-binding should not be underestimated. In patients with restricted renal function or lowered hepatic metabolic capacity, it may lead to a delayed excretion of the drug which has increased penetration into the tissues.

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“…The lower protein binding values in newborns than in their mothers or adults in general have been docu mented in humans and rabbits [10][11][12][13]. A lower plasma albumin level, higher nonesterified fatty acid (NEFA) concentrations, or changes in bilirubin levels of newborns have all been considered in an attempt to under stand this difference [14,15]. However, the wide physiological and analytical variability of cases in previous reports has limited the interpretation of their findings, so no sys tematic and comprehensive profile is yet available.…”

Section: Introductionmentioning

confidence: 99%

Plasma Protein Binding of Theophylline during Development in the Rabbit

et al. 1991

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The plasma protein binding profile of theophylline was investigated in the rabbit during the perinatal and developmental period. The roles of unbound plasma theophylline fraction (TH_u), albumin, nonesterified fatty acids (NEFA) and plasma bilirubin levels were analyzed. Plasma total protein and albumin levels doubled with age from the 1st day of life to maturity (from 3.1 to 5.3 and 1.6 to 3.7 g/l, respectively). TH_U, NEFA and bilirubin levels were inversely related to age, and decreased from 81 to 37%, 2,136 to 239 μEq/l and 2.4 to 0.20 mg/dl, respectively. A linear correlation was shown between TH_u and albumin, NEFA, and bilirubin plasma concentrations. Stepwise multiple linear regression analysis, including albumin, NEFA and bilirubin values as independent variables, identified NEFA as the variable explaining most of the variability in plasma protein binding of theophylline. Findings support the need for careful interpretation (with a view to therapeutic utilization) of estimates of plasma protein unbound fraction of a drug during development. This fact highlights the importance of considering not only protein but NEFA concentrations too.

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The influence of age on the activity of acetylsalicylic acid-esterase and protein-salicylate binding

Cited by 60 publications

References 17 publications

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

Investigations on salicylate protein binding in newborns and infants

Plasma Protein Binding of Theophylline during Development in the Rabbit

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