This study numerically investigates the influence of a sickbed with a semiopened hood on bacteria removal in a negative-pressure isolation room. The parameters include air change rate, lying style, the length and height of hood, flow rate allotments, and the positions of outlets. The results show that the hood has excellent effect on the removal of contaminated air, which is much better than the case without hood. The flow field of patient's face up cough is very different from face side cough, and the contaminated air cannot be removed properly through one air outlet. There are three outlets on the hood, set straight above the patient's face and at both sides. The allotment of the exhaust flow rate of the upper outlet to that of side outlets is suggested to be 4 : 6. When the total air change rate is above 6 ACH, the hood length has slight influence on pollutant removal. The increase of hood height has a negative impact when the patient coughs lying on back. When the side exhaust flow rate is high, the hood height has a slight impact for face side cough. The recommended air change rate for the negative-pressure ward with sickbed hood is above 5 ACH.