The Influence of Anaemia, Polycythaemia and Splenomegaly on the Relationship between Venous Haematocrit and Red‐Cell Volume

Huber, H.; Lewis, S. M.; Szur, L.

doi:10.1111/j.1365-2141.1964.tb00733.x

Cited by 77 publications

(48 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1964, Huber and colleagues (13) found the average increase in hemoglobin concentrations was 0.9 ± 0.1 g/dL) in a study of 16 adult patients with mild splenomegaly. Our study confirms this finding.…”

Section: Discussionmentioning

confidence: 97%

“…On the basis of data from a previous study (13), it was assumed that the change in hemoglobin over 24 hours would be 18 ± 8 g/L for a 2-unit transfusion. Controlling the probability of a type I error at a = 0.05, a sample of 34 patients would yield 80% power to detect a change in hemoglobin of 0.5 SDs or a 4 g/L change in hemoglobin levels.…”

Section: Experimental Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Equilibration of Hemoglobin Concentration after Transfusion in Medical Inpatients Not Actively Bleeding

Wiesen

Hospenthal²,

Byrd³

et al. 1994

Ann Intern Med

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Section: Experimental Measurementsmentioning

confidence: 99%

Equilibration of Hemoglobin Concentration after Transfusion in Medical Inpatients Not Actively Bleeding

Wiesen

Hospenthal²,

Byrd³

et al. 1994

Ann Intern Med

View full text Add to dashboard Cite

“…Potycythemia due to primary and secondary erythrocytosis could be associated with hypervolemia. 32 The hypervolemia may represent an important determinant of the structural alteration of the cardiovascular system, including the heart. The structural change may result, by some mechanism, in a system less responsive to the action of ANF.…”

Section: Discussionmentioning

confidence: 99%

Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats.

et al. 1991

View full text Add to dashboard Cite

The present study was designed first to investigate the pulmonary hypertensive effects of chronic hypoxia in spontaneously hypertensive rats and second to compare the cardiovascular effects of atrial natriuretic factor on rats exposed to hypoxia and on control rats kept at sea level. Catheters were placed in the femora] and pulmonary arteries for measurement of mean systemic arterial pressure and mean pulmonary arterial pressure. The cardiac output was measured by thermodilution method. It was found that 4 weeks of simulated 18,000-foot hypoxia led to polycythemia, right ventricular hypertrophy, and pulmonary hypertension, which resulted from an increased pulmonary vascular resistance. However, systemic arterial pressure was not significantly different between the two groups of rats. Atrial natriuretic factor administration decreased systemic arterial pressure and pulmonary arterial pressure to a lesser extent in the hypoxic group compared with the sea level control group. It is concluded that these animals snowed an impaired response to atrial natriuretic factor after long-term exposure to hypoxia. (Hypertension 1991;18u355-359) A trial natriuretic factor (ANF) possesses potent vasorelaxant properties in blood vessels and natriuretic and diuretic effects in the kidney after exogenous administration as well as endogenous release.1 Changes in plasma ANF concentration or the sensitivity to ANF have been shown to be associated with alterations of body fluid 2 "4 and with diseases such as nephrotic syndrome, 56 experimental cirrhosis, 7 bile duct ligation, 8 and especially hypertension. Tikkanen et al 9 showed that NaCl and deoxycorticosterone acetate-NaCI loading increased plasma ANF levels and that elevated blood pressure did not stimulate ANF release further. Sonnenberg et al 10 reported a decreased atrial content of ANF in the spontaneously hypertensive rat (SHR), but Pettersson et al 4 showed that basal plasma ANF levels were similar in the SHR and Wistar-Kyoto rats. Nevertheless, most reports agreed that the increase in plasma ANF was attenuated during acute volume expansion in SHR rats.2 -4 The sensitivity of blood pressure drop after exogenously administered ANF in the normotensive and hypertensive rats is also controversial.3 ' 1112 ANF may play an important role Received October 15, 1990, accepted in revised form April 29, 1991. in the pulmonary hypertension induced by hypoxia. 13Acute hypoxia stimulates the release of ANF from isolated hearts 14 and increases plasma ANF in anesthetized rabbits 15 and pigs. 16 In the chronic hypoxia of widespread lung disease or high altitude residents or animals pulmonary hypertension, ventricular hypertrophy, and polycythemia may develop. 17 In rats exposed to 21 days of hypoxia, the left atrial ANF content was significantly increased, whereas right atrial ANF content was significantly reduced, and plasma ANF concentration was elevated compared with air control animals. 18ANF has a direct effect on the pulmonary vasculature, causing relaxation of isolated segments of...

show abstract

“…In the present study the mean increase of Hb 6 hours and 24 hours after transfusion were 0.39 gm/dl and 1.14 gm/dl respectively. Huber et al (1964) 18 found the average increase in hemoglobin concentrations was 0.9 ±0.1 g/dL) in a study of 16 adult patients with mild splenomegaly. Wiesen et al (1994) 23 in their study concluded that transfusion with 1 unit of packed erythrocytes increases the hemoglobin level an average of 10 g/L (1.0 g/dL).…”

Section: Methodsmentioning

confidence: 99%

“…A common assumption among clinicians is that the transfusion of one unit of blood will result in a 3% increase in the hematocrit or 1 g/dL of hemoglobin [18][19][20][21] . It has been implied that blood volume is expanded immediately after transfusion and does not return to normal for 24 hours 22 .…”

Section: Methodsmentioning

confidence: 99%

Equilibration and Increase of Hemoglobin Concentration after One Unit Whole Blood Transfusion among Patients Not Actively Bleeding

Hoque

Adnan

Karim³

et al. 2015

J Dhaka Med Coll

View full text Add to dashboard Cite

show abstract

The Influence of Anaemia, Polycythaemia and Splenomegaly on the Relationship between Venous Haematocrit and Red‐Cell Volume

Cited by 77 publications

References 13 publications

Equilibration of Hemoglobin Concentration after Transfusion in Medical Inpatients Not Actively Bleeding

Equilibration of Hemoglobin Concentration after Transfusion in Medical Inpatients Not Actively Bleeding

Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats.

Equilibration and Increase of Hemoglobin Concentration after One Unit Whole Blood Transfusion among Patients Not Actively Bleeding

Contact Info

Product

Resources

About