The Influence of Anovulatory Compounds on Cholesterol Metabolism

Alfin-Slater, Roslyn B.; Aftergood, Lilla

doi:10.1007/978-1-4615-6866-7_41

Drugs Affecting Lipid Metabolism

1969

DOI: 10.1007/978-1-4615-6866-7_41

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The Influence of Anovulatory Compounds on Cholesterol Metabolism

Roslyn B. Alfin-Slater

Lilla Aftergood

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1971

1973

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Cited by 2 publications

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Lipids and the pill

Alfin-Slater

Aftergood

1971

Lipids

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The widespread use of anovulatory compounds and the well‐known effects of sex hormones on various aspects of metabolism prompted this review of our work and the work of others on observed changes in lipid metabolism resulting from the administration of oral contraceptives and their components. In the rat, female sex hormone administration results in a decreased plasma cholesterol level, an accumulation of cholesterol in liver and a decreased hepatic cholesterol biosynthesis. On the other hand, cholesterol biosynthesis is enhanced in ovaries and adrenals. There is also a diminished alpha lipoprotein content and a corresponding decrease in the alpha/beta lipoprotein ratio. In some cases these changes are comparable to those observed during pregnancy. The results of sex hormone administration to women are more variable. In this case the most often observed effect is hypertriglyceridemia. Changes in lipoprotein content and distribution are also evident and may be the result of changes in metabolism in the liver, e.g., lipid synthesis or lipid transport from liver to plasma and tissues, or both. Many of these changes may be mediated indirectly through the action of estrogenprogestin on other hormones. In both species the effects of oral contraceptives are attributable principally to the estrogen component. The combination of estrogen with progestin compounds, which constitutes the oral contraceptive, modifies the effects of estrogen administered alone.

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Lipids and the pill

Alfin-Slater

Aftergood

1971

Lipids

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Influence of Dietary Lipids on Plasma and Hepatic Lipids and on Blood Clotting Properties in Rats Fed Oral Contraceptives

Tabacchi

Kirksey

1973

The Journal of Nutrition

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The Influence of Anovulatory Compounds on Cholesterol Metabolism

Cited by 2 publications

References 11 publications

Lipids and the pill

Lipids and the pill

Influence of Dietary Lipids on Plasma and Hepatic Lipids and on Blood Clotting Properties in Rats Fed Oral Contraceptives

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