Background. With the changing paradigm from primarily hard tissue to soft tissue evaluation for orthodontic diagnosis and treatment planning, the priority has shifted to bring about improvement in the profile and smile characteristics of patients. Since not only the esthetics but also the stability of orthodontic treatment is largely determined by the soft tissue envelope, proper positioning of the soft tissue drape becomes paramount. Soft tissues of face, namely, nose, lips, and chin, are of paramount importance not only from an esthetic but also from functional and treatment stability points. Objective. To determine the morphological variation of lips, nose, and chin in different skeletal malocclusions. Materials and Methods. Lateral cephalograms of 237 patients visiting the department of orthodontics, BPKIHS, were taken, hand traced on matt acetate tracing paper of 0.002″ thickness with 0.3-mm 2B pencil. Samples were divided into 3 skeletal classes based on ANB angle. Measurements were made in relation to the nose, lips, and chin. Data were inserted in to SPSS and analyzed statistically using descriptive statistics, and mean and standard deviation was calculated for each variable. Multiple comparison between groups was done with post hoc Bonferroni test with mean difference significant at
p
<
0.05
. Result. On intergroup comparison, a significant difference was found for upper lip thickness (ULT) between Class II and Class III, and lower lip length (LLL) between Class I and Class III, and between Class II and Class III. Significant difference for nasolabial angle (NLA) was found between Class II and Class III. Similarly, a significant difference for the vertical chin parameter (CTV) was found between Class I and Class III, and between Class II and Class III. Conclusion. Both upper and lower lip thicknesses were highest for Class III followed by Class I and Class II, respectively. Lip lengths too were found to be highest for Class III skeletal relation. Nasolabial angle was larger in Class II malocclusion when compared to Class I and Class III. Similarly, both nasal length and nasal height measurements were in the order of Class III > Class II > Class I. Both horizontal and vertical chin parameters were larger for Class III sagittal relation.