The Influence of Aspirin on Gastrointestinal Microbleeding in Dogs With Gastric Ulcers

Phillips, Barrie M.; Quiring, John; Hurley, James W.; Myers, Carl E.; Hartnagel, Ralph E.; Kowalski, Robert L.

doi:10.1016/b978-0-08-021308-8.50294-5

Cited by 1 publication

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“…This finding parallels observations made in the case of aspirin (4). Aspirin does produce bleeding or mucosal erosions, but never ulcers which penetrate into the muscularis mucosa, at least in dogs (3,6,7). Phillips et al (3) demonstrated that the effect of aspirin on gastrointestinal bleeding in dogs with gastric ulcers was essentially the same as the effect in dogs without ulcers.…”

Section: Discussionsupporting

confidence: 74%

“…Aspirin does produce bleeding or mucosal erosions, but never ulcers which penetrate into the muscularis mucosa, at least in dogs (3,6,7). Phillips et al (3) demonstrated that the effect of aspirin on gastrointestinal bleeding in dogs with gastric ulcers was essentially the same as the effect in dogs without ulcers. Consequently, the claim that aspirin is capable of causing massive gastric bleeding in patients with peptic ulcer disease may be incorrect.…”

Section: Discussionmentioning

confidence: 99%

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Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Okabe¹,

Tabata²

1981

Digestion

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Effects of indomethacin on healed or partially healed gastric ulcers in the dog were studied. Gastric ulcers were produced by submucosal injection of 1 ml of 40% acetic acid solution into the bordering area of the fundus and antrum of the stomach. Indomethacin, 20 mg/kg, was given orally once daily for 5 days beginning on the 50th day after ulceration. While erosions or deep ulcers were produced by indomethacin, healed or partially healed acetic acid ulcers were not aggravated. Mechanisms involved in this strong resistance of healed ulcers to the ulcerogenic agent remain to be determined.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%