The Influence of Assisted Reproductive Technology on Women with Pregnancy-induced Hypertension: A Retrospective Study at a Japanese Regional Perinatal Center

Iwasaki, Nao; Nakai, Asami; Suzuki, Shunji; Takeshita, Toshiyuki

doi:10.1272/jnms.77.312

Cited by 12 publications

(9 citation statements)

References 11 publications

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“…Furthermore, a high number of retrieved oocytes (≥ 20) was not predictive for the development of preeclampsia in our cohort, and the number of oocytes retrieved did not show a significant relationship with the degree of gestational rise in arterial compliance as reflected by declining PWV or rising PWTT at any of the time points evaluated during pregnancy. In the medical literature, IVF involving superovulatory cycles has been associated with increased risk of preeclampsia in some [28][29][30][31][32] , but not all 33,34 reports, particularly when adjusted for plurality 35 . Closer examination of this literature reveals that studies reporting increased risk of preeclampsia with IVF have often grouped both fresh (multiple CL) and frozen (frequently absent CL) transfers together 28,32,36,37 ; therefore, one cannot discern whether the increased risk was seen with both fresh and frozen transfer.…”

Section: Discussionmentioning

confidence: 99%

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

et al. 2019

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In vitro fertilization involving frozen embryo transfer (FET) and donor oocytes increases preeclampsia risk. These IVF protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether IVF pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Women with 0 (n=26), 1 (n=23), or >1 (n=22) CL were serially evaluated before, during and after pregnancy. Because increasing arterial compliance is a major physiological adaptation in pregnancy, we assessed carotid-femoral pulse wave velocity (cfPWV) and transit time (cfPWTT). In a parallel, prospective

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Section: Discussionmentioning

confidence: 99%

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

et al. 2019

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“…Miyake et al [18] found in their retrospective study that the preeclampsia increased the rates of cesarean section, and the massive maternal hemorrhage increased. In our study, we found that 96.1% of the mothers delivered by…”

Section: Discussionmentioning

confidence: 98%

The clinical outcomes of the newborns of the preeclamptic mothers

Tiryaki¹,

Suzan²,

Altınkaynak³

et al. 2019

Perinatal J

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Amaç: Bu çal›flma yenido¤an yo¤un bak›m ünitesinde yatan, maternal preeklampsi/eklampsi tan›s› olan annelerin bebeklerinin özelliklerinin retrospektif olarak literatür eflli¤inde incelenmesi amac›yla planland›. Yöntem: Bir e¤itim ve araflt›rma hastanesinde 1 Ocak-31 Aral›k 2018 tarihleri aras›nda preeklampsi/eklampsi tan›s›yla do¤umu gerçekleflen, do¤um sonras› ayn› hastanenin yenido¤an yo¤un ba-k›m ünitesinde yat›r›larak izlem, tetkik ve tedavisi yap›lan bebeklerin hastane bilgi yönetim sisteminden elde edilen epikriz dosya-lar›, hastane yönetimi ve etik kurul onay› al›nd›ktan sonra incelenerek retrospektif olarak de¤erlendirildi. Bulgular: Çal›flmaya dahil edilen 51 bebe¤in annelerinin yafl ortala-mas› 32.21±6.20, bebeklerin do¤duklar›ndaki gebelik haftas› 34.21± 3.33, ortalama do¤um a¤›rl›klar› 2177±1007 gram olarak bulundu. Annelerin neredeyse tamam›n›n (%98) spontan (kendili¤inden) gebe kald›¤›, %9.8'inin (n=5) ikiz gebelik oldu¤u, %31.4'ünün (n=16) ek hastal›klar›n›n (gestasyonel diyabet, epilepsi, hipotiroidi) oldu¤u saptand›. Klini¤e kabul edilen bebeklerin yat›fll› olduklar› günlerde %58.8'i nazal sürekli pozitif hava yolu bas›nç deste¤i, %5.9'u mekanik ventilatör deste¤i, %51'i aral›kl› fototerapi ald›. Bebeklerin tam enterale geçifl günleri 10.72±13.87 (aral›k: 1-64) olarak belirlendi. Bebeklerinden 3 tanesi yat›fllar›n›n 2. günü, 12. günü ve 23. gününde hayat›n› kaybetmiflti. Bebeklerin %90.2'si sadece anne sütü (anne memesini emerek), %9.8'i hem anne sütü hem de mama alarak taburcu olmufltu. Sonuç: Preeklamptik anne bebeklerine yaklafl›mda; prematürite ve buna sekonder geliflen komplikasyonlar baflta olmak üzere geliflebilecek di¤er sorunlar›n erken dönemde fark edilmesi, yenido¤an yo¤un bak›m ünitesi koflullar›n›n düzenlenmesi ve multidisipliner ekiplerin oluflturulmas› ile preeklampsiye ba¤l› geliflen perinatal mortalite ve morbiditenin azalt›laca¤› kan›s›nday›z.

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“…A multiple pregnancy often increase uterine pressure to an unusually high level, which cause severe placental ischemia and hypoxia, resulting in vascular endothelial cell damage and dysfunction. Thus, a multiple pregnancy is a risk factor for hypertensive disorders in pregnancy ( 23 ). It is also arguable that the embryos obtained from donated eggs were allogeneic to the pregnant mother, thus immune system attacks inflict damage to the body, and increase the risk of hypertensive disorders in pregnancy ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

Xiong¹,

Hu²,

Zhang³

et al. 2017

Exp Ther Med

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We investigated the correlation of hypertensive disorders in pregnancy with different procedures of in vitro fertilization, and analyzed pregnancy outcomes of patients with hypertensive disorders in pregnancy. A retrospective analysis was performed on the medical records of 658 maternity patients who conceived through in vitro fertilization in Maternal and Child Health Hospital of Wuxi. Patients were divided into two groups according to different fertilization procedures: i) the routine in vitro fertilization-embryo transfer group (IVF-ET group, 377 cases) and ii) intra-cytoplasmic sperm injection-embryo transfer group (ICSI-ET group, 281 cases). Consequently, patients were further divided into two groups according to different embryo transfer cycles: the fresh embryo transfer group (F-ET group, 446 cases) and the frozen-thawed embryo transfer group (T-ET group, 212 cases). Characteristics of patients in each group were evaluated, and incidence of hypertensive disorders in pregnancy resulting from different assisted reproductive technology was compared. Among patients who conceived through IVF, there were 56 cases of hypertensive disorders in pregnancy, including 21 cases of gestational hypertension, 34 cases of pre-eclampsia and 1 case of eclampsia. The odds ratio (OR) of gestational hypertension in the comparison between the ICSI-ET and IVF-ET groups was 2.01 (0.81–4.74), and was reduced to 1.69 (0.70–4.02) after correction. The difference of OR in twin-birth patients of the two groups was statistically significant, but the difference in single-birth patients was not statistically significant. The odds ratio (OR) of gestational hypertension in the comparison between the F-ET and T-ET groups was 0.44 (0.13–1.34), and became 0.49 (0.15–1.51) after correction. The odds ratio of pre-eclampsia in the comparison between the ICSI-ET and IVF-ET groups was 1.36 (0.42–4.18), and was reduced to 1.17 (0.36–3.62) after correction. The odds ratio of pre-eclampsia in the comparison between the F-ET and T-ET groups was 0.93 (0.42–1.96), and became 0.98 (0.44–2.12) after correction. The differences were not statistically significant. The risk of onset of hypertensive disorders in pregnancy has a certain correlation with the ICSI fertilization technology, but has no apparent correlation with embryo transfer cycles.

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The Influence of Assisted Reproductive Technology on Women with Pregnancy-induced Hypertension: A Retrospective Study at a Japanese Regional Perinatal Center

Cited by 12 publications

References 11 publications

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

The clinical outcomes of the newborns of the preeclamptic mothers

Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

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