The influence of asthma on neuroinflammation and neurodevelopment: From epidemiology to basic models

Tamayo, Juan M.; Osman, Hadley C.; Schwartzer, Jared J.; Ashwood, Paul

doi:10.1016/j.bbi.2023.12.003

Cited by 9 publications

(3 citation statements)

References 200 publications

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“…Numerous studies show that AS is a disease that is associated with type 2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, which promote AS symptoms such as airway eosinophilia, overproduction of mucus, bronchial hyperresponsiveness, and high levels of IgE ( Steinke and Borish, 2001 ; Kuruvilla et al, 2019 ; Wang et al, 2023 ). Similarly, symptoms of AR and food and skin allergies are induced by the acute, intermittent, or chronic type 2 (T2) inflammation and secretion of pro-inflammatory cytokines and eotaxins that can cross the blood–brain barrier, resulting in neuroinflammation ( Tamayo et al, 2024 ). Importantly, Guedes et al (2023) demonstrated the impact of elevated IL-4 levels during cerebellar maturation and provided the first line of evidence for a mechanistical link between allergic disease and ADHD in humans.…”

Section: Discussionmentioning

confidence: 99%

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Ding,

2024

Front. Pharmacol.

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We describe the case of a 10-year-old boy with asthma (AS), accompanied by allergic rhinitis (AR), food allergy (FA), and combined attention-deficit/hyperactivity disorder (ADHD), who was treated at Shanghai Renji Hospital on 11 July 2020. The efficiency of the previous treatment with salmeterol/ticlosone was poor. Treatment with montelukast sodium resulted in development of neurological symptoms. Treatment with omalizumab in combination with subcutaneous immunotherapy (SCIT) was then initiated in our department based on anti-asthmatic therapy. Symptoms of asthma were completely controlled, and FA and AR symptoms improved. The treatment regimen led to a significant improvement in ADHD symptoms and the overall quality of life of the patient. The literature search was done in the PubMed database using “attention deficit/hyperactivity disorder/ADHD” and “asthma” as keywords, and we identified 47 relevant articles. In conclusion, our results show that treating asthma with omalizumab in combination with salmeterol/ticlosone and SCIT is efficient in controlling symptoms of multiple allergies and may lead to the improvement in ADHD symptoms and the overall quality of life of pediatric patients with ADHD. While current studies suggest that allergic diseases are closely related to ADHD, there is still a lack of studies or case reports of complete treatment protocols to provide clinical clues for management of the disease.

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Section: Discussionmentioning

confidence: 99%

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Ding,

2024

Front. Pharmacol.

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“…A large body of studies have assessed the acute manifestations of inflammation in maternal and fetal organs induced by LPS, vira or poly I:C administered via intravenous, -peritoneal or -uterine routes 2 , 4 , 7 . Much less work has delineated the downstream manifestations of immunogens targeted to the lungs, including maternal airway inflammation arising from environmental dust and respiratory infections 8 – 14 . The latter are common during pregnancy: 49.6% of control mothers in the National Birth Defects Prevention Study reported respiratory infections during pregnancy 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

“…immunogens targeted to the lungs, including maternal airway inflammation arising from environmental dust and respiratory infections [8][9][10][11][12][13][14] . The latter are common during pregnancy: 49.6% of control mothers in the National Birth Defects Prevention Study reported respiratory infections during pregnancy 15,16 .…”

mentioning

confidence: 99%

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Hansen,

Krautz,

Rago

et al. 2024

Nat Commun

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The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.

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First episode depression during the perinatal period is associated with atopic diseases and persistently increased eosinophil and basophil levels

Wagner,

Pichler,

Müller

et al. 2024

Arch Womens Ment Health

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Purpose A previous diagnosis of depression is a strong predictor for perinatal depression, apart from other mental disorders, stress, and atopies. It is less clear which factors interfere if perinatal depression occurs as a first depression episode (fePND). Methods We examined the associations with atopies and related blood parameters using data of CoLaus|PsyCoLaus. Results Newly occurring depression during the perinatal period but not recurrent depression was associated with a lifetime diagnosis of allergies and asthma together with persistently increased levels of basophils and eosinophils. Conclusion The results imply that immune function may play a relevant role in the risk of a fePND. If confirmed and detailed, these findings could serve as the basis for designing preliminary prevention strategies by observing eosinophil and basophil levels as well as symptoms of atopic diseases before/during pregnancy.

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The influence of asthma on neuroinflammation and neurodevelopment: From epidemiology to basic models

Cited by 9 publications

References 200 publications

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

First episode depression during the perinatal period is associated with atopic diseases and persistently increased eosinophil and basophil levels

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