The influence of B-cell idiotypes on the repertoire of suppressor T cells

HayGlass, Kent T.; Benacerraf, Baruj; Sy, Man Sun

doi:10.1016/0167-5699(86)90170-2

Cited by 11 publications

(1 citation statement)

References 27 publications

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“…Some recent observations suggest that this model has major implications for therapy with anti-idiotypes, since these might preferentially activate Ts. In an analysis of IgH-restricted T cell responses to the hapten azobenzenearsonate, the nature of immunoglobulin idiotopes was found to determine the development of Ts idiotopes [20,21]. T cells developing in IgH congenic mice acquired the idiotypic repertoire of the host, and treatment of neonatal animals with antibodies to the /x immunoglobulin chain abolished the establishment of a normal repertoire of functional T cell idiotypes.…”

Section: Idiotypic Interactions Initiated By Antigenic Stimulimentioning

confidence: 99%

Anti-idiotypic antibodies and the induction of specific tumor immunity

Nepom

Hellström

1987

Cancer Metast Rev

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Immunization with anti-idiotypic antibodies is a strategy which, with variable success, can be used to elicit or amplify antigen-specific immune response. This article discusses the manipulation of specific idiotypes in anti-tumor immunity, emphasizing the appropriate consideration of genetic restriction, the choice of idiotype specificity, and the route of immunization. Two independent pathways are outlined: One uses anti-idiotypic antibodies to select and amplify tumor-specific T and B cells via their preexisting antigen-specific receptors, and the other uses anti-idiotypes as primary internal image immunogens to elicit immune recognition of determinants shared by the anti-idiotype and by tumor-associated antigens. Both pathways can be manipulated in attempts to favor the generation of anti-tumor effector cells and minimize the elicitation of suppression. Anti-idiotypic immunization can be utilized to induce therapeutic immune reactivity in hosts lacking effective direct anti-tumor responses. By stimulating 'silent', or normally suppressed, T and B cell clones, appropriate immunization strategies can circumvent immune regulatory pathways associated with suppressor cells and factors derived from such cells. In these studies, adequate characterization of antitumor idiotype and anti-idiotype specificities is key to the experimental approach to tumor therapy using antibodies. The importance of individual host genetic variation in the specificity and scope of immune response to anti-idiotypic immunoglobulins is unknown, and remains an important potential barrier to therapeutic management.

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Section: Idiotypic Interactions Initiated By Antigenic Stimulimentioning

confidence: 99%

Anti-idiotypic antibodies and the induction of specific tumor immunity

Nepom

Hellström

1987

Cancer Metast Rev

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New assay to detect shedding antigen with use of anti‐idiotypic monoclonal antibodies

Tsujisaki¹,

Imai²,

Tokuchi³

et al. 1991

Clinical Laboratory Analysis

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Anti-idiotypic (Anti-Id) monoclonal antibodies (MoAbs) against anti-carcinoembryonic antigen (CEA) monoclonal antibody 5B3 (IgG1) were prepared and characterized. Five anti-Id MoAbs recognized the private idiotype of MoAb 5B3. Idiotype mapping suggested that MoAb 5B3 had at least three distinct idiotopes at its antigen combining site. Utilizing the inhibition of idiotype-anti-idiotype interaction with use of anti-Id MoAb T4-305 or T4-212, an immunoassay to detect shedding CEA was established. The results of this inhibition assay correlated with those of double determinant immunoassay and inhibition percentages linearly increased in a CEA concentration-dependent manner. Since it requires only one epitope of a given antigen molecule, this assay could be widely used for detection of shedding antigens, including tumor-associated antigens.

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Epitypic-Idiotypic Dominance as An Evolutionary Answer to the Intercellular Communication Problem

Sercarz

1988

The Semiotics of Cellular Communication in the Immune System

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The influence of B-cell idiotypes on the repertoire of suppressor T cells

Cited by 11 publications

References 27 publications

Anti-idiotypic antibodies and the induction of specific tumor immunity

Anti-idiotypic antibodies and the induction of specific tumor immunity

New assay to detect shedding antigen with use of anti‐idiotypic monoclonal antibodies

Epitypic-Idiotypic Dominance as An Evolutionary Answer to the Intercellular Communication Problem

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