The Influence of Bariatric Surgery on the Course of Cardiovascular Diseases

Gorbachova, V.V.; Тодуров, І. М.; Плегуца, О. І.; Khorevina, K.M.; Калашніков, О. О.

doi:10.15407/fz67.05.064

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Порівнюючи із аналогічними показники перед початком передопераційної підготовки отримана різниця ставала вірогідною (Z = 4,9; Р = 0,001 та t = 18,1; Р = 0,001). Хірургічний метод лікування ожиріння та метаболічних порушень давно зарекомендував себе як єдиний, котрий має довгостроковий, задовільний та стійкий результат зниження надлишку маси тіла та компенсації супутньої патології [2,19]. І, як наслідок, щорічне збільшення кількості баріатричних операцій на всіх континентах [3].…”

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Low-Calorie, High-Protein, Low-Carbohydrate Diet Is an Effective Method of Reducing Excess Body Weight

Todurov¹,

Kalashnikov²,

Kosiukhno³

et al. 2022

Fiziol Zh

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The aim of our study was to evaluate the safety and efficacy of a 2-week ultra-low-calorie, high-protein, low-carbohydrate diet to reduce body weight, left liver volume, and correct biochemical parameters in patients with planned bariatric surgery. A retrospective analysis of the treatment of 32 patients (23 men and 9 women) with morbid obesity who were in the surgical department from 2018 to 2021. They underwent preoperative preparation followed by laparoscopic hose resection of the stomach. The mean age of patients was 43.8 ± 11.7 years, body weight - 175.5 kg (167.5-193.8 kg), body mass index (BMI) - 58.8 ± 10.3 kg/m2, area left lobe of the liver - 80.9 ± 18 cm2, the average thickness of subcutaneous tissue - 36.5 (25-40) mm, the average level of ALT - 45.8 (41.4 - 61.8) μmol/l, AST - 42, 4 (34.8 - 52.5) μmol/l, total cholesterol - 6.09 ± 0.79 mmol/l, HDL-cholesterol - 0.93 ± 0.22 mmol/l, LDL-cholesterol - 3.75 ± 0.99 mmol/l and triglycerides - 2.09 ± 0.66 mmol/l. 2 weeks after the start of the diet, the percentage of weight loss (% BMD) reached 9.9 ± 2.7% (5.6-16.5%), body weight - 164.5 kg (153.8-184.3 kg) and the average value of BMI - 55.4 ± 9.7 kg/m2, the area of the left lobe of the liver - 69.6 ± 17.5 cm2, the average thickness of subcutaneous tissue - 31.5 (22-37) mm, the average level of ALT - 42.8 (28.8 - 49.2) μmol/l, AST - 29.3 (22.9 - 37.7) μmol/l, total cholesterol - 5.24 ± 0.83 mmol/l, HDL -HS - 1.19 ± 0.2 mmol/l, LDL-cholesterol - 4.57 ± 0.87 mmol/l and triglycerides - 1.65 ± 0.78 mmol/l. Thus, prescribing an ultra-low-calorie, high-protein, low-carbohydrate diet is a safe and effective way to reduce excess weight, reduce anterior abdominal wall thickness, reduce left liver size, and correct biochemical parameters in high-risk patients before bariatric surgery.

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Section: вступunclassified

Low-Calorie, High-Protein, Low-Carbohydrate Diet Is an Effective Method of Reducing Excess Body Weight

Todurov¹,

Kalashnikov²,

Kosiukhno³

et al. 2022

Fiziol Zh

Self Cite

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“…There is a lot of clinical and experimental evidence that almost all organs and systems of the body are involved in the pathological process caused by excess body weight. Obesity has been shown to lead to a number of serious diseases, such as hypertension, type 2 diabetes, and coronary heart disease [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of L-tryptophan on the bone biophysical properties and oxygen consumption in rats with diet-induced obesity

Chaka¹,

Nosar²,

Zinchenko³

et al. 2022

Fiziol Zh

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The purpose of the study was to evaluate the effect of L-tryptophan on the biophysical properties of bone tissue and oxygen consumption in rats with diet-induced obesity. The study was conducted on 40 male 3-months- aged Wistar rats. The photometric determination of phosphorus and calcium concentration in the femoral bones was conducted. The rate of oxygen consumption was measured according to chronoamperograms. The biophysical properties of femurs were measured by a methodic three-point bending test. It was shown that the content of calcium (by 15%) and phosphorus (by 20%) was significantly higher in the femurs of rats that received L-tryptophan (at a dose of 80 mg/kg per os) for 28 days compared to the control parameters. The rate of oxygen consumption, density and biophysical properties of the femurs did not change. As a result of the consumption for three months of a high-calorie diet (580 kcal/100 g) in experimental rats clear features of obesity evolved. Thus, they had a greater visceral fat mass (by 145%), a visceral fat mass to body weight ratio (by 122%), and an obesity index (by 145%). In rats with alimentary obesity, the calcium and phosphorus content in the femurs was significantly reduced by 28 and 24%, respectively, and the rate of oxygen consumption was 45% lower than in control animals. Femur bearing capacity, strength limit, and stiffness were significantly lower, namely on 23, 11, and 37%, respectively. Administration of L-tryptophan to rats, against the background of consumption of a high-calorie diet, inhibited the development of obesity. Visceral fat mass and its ratio to body weight in this group of rats were 38 and 23% lower, respectively, compared to the obese group. The concentration of calcium (by 32%) and phosphorus (by 25%) and oxygen consumption rates (by 31%) were significantly greater compared to rats fed only the high-calorie diet. Our research shows that the administration of L-tryptophan to obese animals can prevent the development of negative changes in bone tissue.

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The Influence of Bariatric Surgery on the Course of Cardiovascular Diseases

Cited by 2 publications

References 35 publications

Low-Calorie, High-Protein, Low-Carbohydrate Diet Is an Effective Method of Reducing Excess Body Weight

Low-Calorie, High-Protein, Low-Carbohydrate Diet Is an Effective Method of Reducing Excess Body Weight

Effect of L-tryptophan on the bone biophysical properties and oxygen consumption in rats with diet-induced obesity

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