The influence of basal metabolic rate on blood pressure among indigenous Siberians

Snodgrass, J. Josh; Leonard, William R.; Sorensen, Mark; Tarskaia, Larissa A.; Mosher, M. J.

doi:10.1002/ajpa.20851

Cited by 69 publications

(81 citation statements)

References 88 publications

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“…A number of risk factors are associated with the development of hypertension, including less physical activity, excess body fat, intake of high dietary sodium and low potassium, more alcohol consumption, and chronic psychosocial stress; these risk factors, however, cannot fully explain the variation in blood pressure and hypertension prevalence that occurs within and between human populations [1, 13, 18, 42]. At present, the specific causes of hypertension are unknown in nearly 90–95% individuals [13, 21].…”

Section: Introductionmentioning

confidence: 99%

Hypertension prevalence and influence of basal metabolic rate on blood pressure among adult students in Bangladesh

et al. 2017

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BackgroundHypertension is a global health issue and is currently increasing at rapid pace in South Asian countries including Bangladesh. Although, some studies on hypertension have been conducted in Bangladesh, there is a lack of scientific evidence in the adult student population that was missing from the previous and recent national cross-sectional studies. Moreover, the specific risk factors of hypertension in the Bangladeshi adults still need to be investigated. This study was conducted to estimate hypertension prevalence among adult students in Bangladesh and to test the hypothesis of Luke et al. (Hypertension 43:555–560, 2004) that basal metabolic rate (BMR) and blood pressure are positively associated independent of body size.MethodThe data was collected on 184 adult university students (118 female and 66 male) in Dhaka, Bangladesh. Anthropometric, BMR details and an average of at least two blood pressure measurements were obtained. Hypertension was defined by a systolic blood pressure (SBP) ≥ 140 mmHg and/or, diastolic blood pressure (DBP) ≥ 90 mmHg.ResultsOverall, 6.5% of participants had hypertension with significantly (p < 0.001) higher prevalence in male (12.1%) than in the female (3.4%) students. Age and BMI showed positive and significant correlation with hypertension among the students. When adjusted for body mass index (BMI), as well as other potentially confounding variables such as age, sex, smoking status and degree of urbanization, BMR was positively correlated with SBP and DBP (p < 0.001). Thus, higher BMR is associated with SBP and DBP; this is opposite the well documented inverse relationship between physical activity and blood pressure. If the influence of BMR on blood pressure is confirmed, the systematically elevated BMR might be an important predictor that can explain relatively high blood pressure and hypertension in humans.ConclusionThis study reports the prevalence and associated risk factors of hypertension in the Bangladeshi adult students. The study also showed a positive association between BMR and blood pressure among the participants. A large scale longitudinal study across the country is needed to find out the underlying causes of hypertension in the Bangladeshi adults. In addition, comprehensive and integrated intervention programs focusing on modifiable risk factors are recommended to make awareness and prevent hypertension.

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Section: Introductionmentioning

confidence: 99%

Hypertension prevalence and influence of basal metabolic rate on blood pressure among adult students in Bangladesh

et al. 2017

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“…Consistent with the concept that mtDNA variation has permitted climatic adaptation, mtDNA variation but not nDNA variation has been found to correlate with climatic differences (Balloux et al 2009). Also, the basal metabolic rate of Siberian populations is higher than that of more southern populations (Leonard et al 2002;Snodgrass et al 2005Snodgrass et al , 2008.…”

Section: Mtdna Mutationsmentioning

confidence: 88%

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

Wallace

Chalkia

2013

Cold Spring Harbor Perspectives in Biology

568

532

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The unorthodox genetics of the mtDNA is providing new perspectives on the etiology of the common "complex" diseases. The maternally inherited mtDNA codes for essential energy genes, is present in thousands of copies per cell, and has a very high mutation rate. New mtDNA mutations arise among thousands of other mtDNAs. The mechanisms by which these "heteroplasmic" mtDNA mutations come to predominate in the female germline and somatic tissues is poorly understood, but essential for understanding the clinical variability of a range of diseases. Maternal inheritance and heteroplasmy also pose major challengers for the diagnosis and prevention of mtDNA disease. THE GENETIC CHALLENGES OF mtDNA DISEASES

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“…Compared to US reference data, they have relatively low serum lipid and leptin levels Mosher, 2002;NIH, 2002;Ruhl and Everhart, 2001;Snodgrass et al, 2008;Sorensen et al, 2005).…”

Section: Descriptive Statisticsmentioning

confidence: 96%

Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia

Leonard

Sorensen

Mosher

et al. 2009

American J Hum Biol

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Over the last 20 years, obesity and associated metabolic diseases have emerged as major global health problems. Among urbanizing populations of developing regions of the world, childhood undernutrition often coexists with adult overnutrition, a phenomenon known as the "dual nutritional burden". A recent work (Frisancho 2003: Am J Hum Biol 15:522-532) suggests that linear growth stunting in early childhood may contribute to adult obesity by reducing the body's ability to oxidize fat. We test central aspects of this model drawing on data from 112 adult Buryat herders (53 males; 59 females) from Southern Siberia. The results are consistent with the predictions of the model, but only for women. Shorter Buryat women (height-for-age Z-scores < or = -1) have significantly lower fasting fat oxidation levels compared to their taller counterparts. Shorter women are also significantly heavier and fatter, and have higher serum lipid levels. Among all Buryat women, reduced fat oxidation is significantly correlated with percent body fatness, serum triglyceride levels, and serum leptin levels, after controlling for relevant covariates. Additionally, Buryat women with high dietary fat intakes and low fat oxidation are significantly fatter and have higher lipid and leptin levels than those with low fat intakes and high fat oxidation. These results suggest that developmental changes in fat oxidation may play a role in the origins of obesity among populations with high rates of linear growth stunting. Further longitudinal research is necessary to elucidate the pathways through which early-life undernutrition may increase risks for adulthood obesity and cardiovascular disease.

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The influence of basal metabolic rate on blood pressure among indigenous Siberians

Cited by 69 publications

References 88 publications

Hypertension prevalence and influence of basal metabolic rate on blood pressure among adult students in Bangladesh

Hypertension prevalence and influence of basal metabolic rate on blood pressure among adult students in Bangladesh

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia

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