The Influence of Body Size, Season, Sex, Age and Other Factors upon Some Blood Parameters in Small Mammals

Sealander, John A.

doi:10.2307/1377331

Cited by 65 publications

(51 citation statements)

References 42 publications

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“…In the case of Hb concentration and Hct, the native character states of the highland mice were largely congruent with the typical acclimatization response to hypoxia exhibited by lowland mammals that have no known evolutionary history of residence at high altitude (Monge and León-Velarde, 1991). The elevated Hb concentrations and Hcts observed in the highland deer mice are consistent with results of previous studies of P. maniculatus (Gough and Kilgore, 1964;Hock, 1964;Sealander, 1964;Dunaway and Lewis, 1965;Thompson et al, 1966;Sawin, 1970;Snyder, 1982;Snyder et al, 1982;Wyckoff and Frase, 1990;Hammond et al, 1999;Hammond et al, 2001) (supplementary material TableS1; Fig.3). By contrast, most rodent species that are native to high altitudes appear to have Hb concentrations and Hcts that are substantially lower than those of hypoxia-acclimated laboratory rats or house mice (Hall et al, 1936;Chiodi, 1962;Morrison et al, 1963a;Morrison et al, 1963b;Bullard et al, 1966) and hematological traits in the majority of highaltitude Andean rodents studied by Morrison and colleagues remained unaltered after acclimation to normoxic conditions at sea level (Morrison et al, 1963a;Morrison et al, 1963b).…”

Section: Discussionsupporting

confidence: 86%

Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice

Tufts

Revsbech

Cheviron

et al. 2012

Journal of Experimental Biology

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SUMMARYIn vertebrates living at high altitude, arterial hypoxemia may be ameliorated by reversible changes in the oxygen-carrying capacity of the blood (regulated by erythropoiesis) and/or changes in blood-oxygen affinity (regulated by allosteric effectors of hemoglobin function). These hematological traits often differ between taxa that are native to different elevational zones, but it is often unknown whether the observed physiological differences reflect fixed, genetically based differences or environmentally induced acclimatization responses (phenotypic plasticity). Here, we report measurements of hematological traits related to blood-O 2 transport in populations of deer mice (Peromyscus maniculatus) that are native to high-and low-altitude environments. We conducted a common-garden breeding experiment to assess whether altitude-related physiological differences were attributable to developmental plasticity and/or physiological plasticity during adulthood. Under conditions prevailing in their native habitats, high-altitude deer mice from the Rocky Mountains exhibited a number of pronounced hematological differences relative to low-altitude conspecifics from the Great Plains: higher hemoglobin concentrations, higher hematocrits, higher erythrocytic concentrations of 2,3-diphosphoglycerate (an allosteric regulator of hemoglobin-oxygen affinity), lower mean corpuscular hemoglobin concentrations and smaller red blood cells. However, these differences disappeared after 6weeks of acclimation to normoxia at low altitude. The measured traits were also indistinguishable between the F 1 progeny of highland and lowland mice, indicating that there were no persistent differences in phenotype that could be attributed to developmental plasticity. These results indicate that the naturally occurring hematological differences between highland and lowland mice are environmentally induced and are largely attributable to physiological plasticity during adulthood. Supplementary material available online at

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Section: Discussionsupporting

confidence: 86%

Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice

Tufts

Revsbech

Cheviron

et al. 2012

Journal of Experimental Biology

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“…Climatic conditions and physiologic rhythms may also cause seasonal changes in these parameters (Sealander 1964;DelGiu- Collazos et al 1998;Woods and Hellgren 2003). Annual sinusoidal variations in a range of physiologic and pathologic processes have been related to similar variations in climate that result from the very precise sinusoidal variations in solar patterns, such as day length and maximum solar elevation angle (Fröhlich et al 1997;Dowell et al 2003;Ockene et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Seasonal changes in hematology and serum biochemistry occur in many wildlife species (Sealander 1964;DelGiudice et al 1992;Collazos et al 1998;Woods and Hellgren 2003). These changes have generally been described by separate statistics for spring, summer, autumn, and winter, each derived from data collected in the relevant season.…”

Section: Introductionmentioning

confidence: 99%

A Need for Dynamic Hematology and Serum Biochemistry Reference Tools: Novel Use of Sine Wave Functions to Produce Seasonally Varying Reference Curves in Platypuses (Ornithorhynchus Anatinus)

Macgregor

Holyoake

Connolly

et al. 2017

Journal of Wildlife Diseases

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Seasonal changes in hematology and serum biochemistry results, described by separate reference intervals for different seasons, have been reported in many animals. We developed a novel method to investigate seasonal variation in values and a reference tool (the reference curve) based on sine wave functions that, for suitable variables, represents data more appropriately than a fixed reference interval. We applied these techniques to values observed in blood samples from 126 adult wild platypuses (Ornithorhynchus anatinus; 58 females and 68 males). Samples were collected under isoflurane anesthesia from animals captured in the Inglis Catchment in northwest Tasmania. In general, packed cell volume (PCV), red cell count (RCC), and hemoglobin (Hb) values appeared to be lower than those in two studies that previously reported platypus hematology reference intervals. This likely resulted from reduced stress-related splenic contraction or isoflurane-associated splenic sequestration of red blood cells in our study. Reference curves were described for five variables (PCV, RCC, Hb, albumin, and magnesium). We found evidence that this seasonal variation may result from metabolic changes associated with seasonal variations in environmental temperature. These observations suggest that it is important for researchers reporting platypus hematology and serum biochemistry to look for seasonal changes in their data to ensure it is appropriately interpreted.

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“…Jurgens et al (1981) studied the mechanisms of adaptation of bats to flying, especially the oxygen-carrying capacity of blood and conditions of gas exchange in bats with low body weight. The haematological parameters modifying directly the system of oxygen uptake and delivery in bats were investigated initially in the 1930s (Worth, 1932) and since that time the conditions of oxygen trańsport in certain bat species have become known (Grundboeck & Krzanowski, 1957;Sealander, 1964;Dunaway & Lewis, 1965;Davis et al, 1967;Valdivieso & Tamsitt, 1971;Caire et al, 1981). A number of investigations were done on the haematological parameters in hibernating bats, that is at a time of greatly reduced oxygen requirements and decreased resistance (e.g.…”

Section: Introductionmentioning

confidence: 99%

Haematological values in the serotine bat, Eptesicus serotinus (Schreber, 1774)

Wołk¹,

Ruprecht

1988

Acta Theriol.

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The Influence of Body Size, Season, Sex, Age and Other Factors upon Some Blood Parameters in Small Mammals

Cited by 65 publications

References 42 publications

Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice

Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice

A Need for Dynamic Hematology and Serum Biochemistry Reference Tools: Novel Use of Sine Wave Functions to Produce Seasonally Varying Reference Curves in Platypuses (Ornithorhynchus Anatinus)

Haematological values in the serotine bat, Eptesicus serotinus (Schreber, 1774)

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