The influence of bone marrow aspirates and concentrates on the early volume stability of maxillary sinus grafts with deproteinized bovine bone mineral – first results of a <scp>RCT</scp>

Kühl, Sebastian; Payer, Michael; Kirmeier, Robert; Wildburger, Angelika; Wegscheider, Walther; Jakse, Norbert

doi:10.1111/clr.12101

Cited by 17 publications

(32 citation statements)

References 18 publications

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“…The mean percentage of volume loss was 33.14% for the test group (DBBM + L‐PRF) and 36.71% for the control group (DBBM only). These variations in the volumetric changes were also observed in previous studies . Accordingly, previous studies have demonstrated that the mean volume reduction of DBBM in the maxillary sinus ranges from 15.2% to 21.5% .…”

Section: Discussionsupporting

confidence: 83%

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Pichotano

Molon

Souza

et al. 2019

Clin Implant Dent Rel Res

104

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Purpose To investigate the effectiveness of adding leukocyte and platelet‐rich fibrin (L‐PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation. Materials and Methods Twelve patients requiring two‐stage bilateral maxillary sinus augmentation were enrolled to the study. The elevated sinus cavities were randomly grafted with DBBM + L‐PRF (test) or DBBM alone (control) in a split‐mouth design. Implants were placed in the augmented sites after 4 months in the test group and 8 months in the control group. Bone biopsies were collected during implant placement for histomorphometric evaluation. Resonance frequency analysis was performed immediately after implant placement and at implant loading in both groups. Cone‐beam computed tomography was obtained preoperatively and postoperatively for evaluation of graft volume changes. Results Both procedures were effective for maxillary sinus augmentation. Cone‐beam computed tomography analysis did not reveal differences in graft volume between test and control group at any of the evaluated time points (P > .05). Histological evaluation demonstrated increased percentage of newly formed bone for the test group (44.58% ± 13.9%) compared to the control group (30.02% ± 8.42%; P = .0087). The amount of residual graft in the control group was significantly higher (13.75% ± 9.99%) than in the test group (3.59 ± 4.22; P = .0111). Implant stability quotient (ISQ) immediately after implant placement was significantly higher in the control group (75.13 ± 5.69) compared to the test group (60.9 ± 9.35; P = .0003). The ISQ values at loading did not differ between the groups (P = .8587). Implant survival rate was 100% for both groups. Conclusion The addition of L‐PRF to the DBBM into the maxillary sinus allowed early implant placement (4 months) with increased new bone formation than DBBM alone after 8 months of healing.

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Section: Discussionsupporting

confidence: 83%

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Pichotano

Molon

Souza

et al. 2019

Clin Implant Dent Rel Res

104

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“…It can also be stated that the respective bone substitute material has no negative effect on volume stability. These results confirm findings of a similar study performed by the same working group in which bone marrow aspirates (BMA) and concentrates (BMAC) were added to deproteinized bovine bone mineral (DBBM) in a split‐mouth design . This study showed that neither BMA nor BMAC improved the volume stability of the grafts after six months of healing .…”

Section: Discussionsupporting

confidence: 87%

“…Prospective randomized studies using a split‐mouth design with bilateral sinus augmentation to measure time‐dependent graft resorption three‐dimensionally have, to date, not been published for any material except DBBM + BMA and BMAC. However, taking all bias into consideration, the percentage decrease of volume in both groups – 15% in the control group and 18% in the test group – lies within the range of the above three‐dimensional‐based studies, with 14% for algae‐derived hydroxyapatite, 15.2% for DBBM + BMA, 21.5% for DBBM + BMAC, 25% for autogenous bone and 26% for DBBM alone …”

Section: Discussionsupporting

confidence: 55%

“…The transformed data were loaded into the Voxim® software device (version 6.3, IVS Technology GmbH, Chemnitz, Germany). For volume measurement, the surfaces of the grafted materials in the maxillary sinuses were determined and segmented manually by scrolling through each axial, coronal and transverse slice as already used in another study (Figure ) . The software automatically calculated the resulting volumes in milliliters (mL).…”

Section: Methodsmentioning

confidence: 99%

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The Influence of Particulated Autogenous Bone on the Early Volume Stability of Maxillary Sinus Grafts with Biphasic Calcium Phosphate: A Randomized Clinical Trial

Kühl

Payer

Kirmeier

et al. 2013

Clinical Implant Dentistry and Related Research

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“…Numerous studies have been published on bone graft stability based on two‐dimensional imaging techniques, demonstrating a significant decrease in augmented bone height within 6‐24 months after sinus lifting . Studies have also been reported on the three‐dimensional (3D) volume stability of these grafts . Although being numerous, these studies differ substantially regarding follow‐up time, method of evaluation, bone graft material, and surgical procedures.…”

Section: Introductionmentioning

confidence: 99%

A 2‐year prospective case series on volumetric changes, PROMs, and clinical outcomes following sinus floor elevation using deproteinized bovine bone mineral as filling material

Younes

Cosyn

Bruyckere

et al. 2019

Clin Implant Dent Rel Res

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Background A sinus floor augmentation may be indicated when a lack of hard tissue impedes implant placement. Although clinically successful, evidence supporting the long‐term three‐dimensional stability of the grafted volume is scarce. Second, evidence on the patient's acceptance of this type of treatment is limited. Purpose First is to evaluate the changes in graft volume after lateral wall sinus lifting based on superimposed cone beam computed tomography (CBCT) images and then to assess patient‐reported outcome measures (PROMs) and clinical outcomes. Materials and Methods Partially edentulous patients in need of a sinus lift and fixed reconstruction on at least two neighboring implants were selected for a prospective case series. Lateral wall sinus augmentation was performed using deproteinized bovine bone mineral (DBBM) as the only filling material. Volumetric changes were quantified on the basis of a preoperative CBCT and three postoperative CBCTs (at 2 weeks, 3 months, and 2 years). PROMs and clinical parameters were registered. Results Twenty‐two patients (7 males, 15 females; mean age 59 years) participated of which three patients dropped out during the follow up. Graft volumes amounted to 1418.26 mm3 at 2 weeks, 1201.21 mm3 at 3 months, and 1130.13 mm3 at 2 years postoperative pointing to a relative graft volume stability of 79.7%. Swelling was the leading symptom during the first week. A peak in visual analogue scale scores was observed for pain, swelling, and hematoma the day of surgery and 1 day postoperation with a statistically significant decline between days 3 and 7. Hemorrhage and nose bleeding occurred in 18.2% and 27.3% of the subjects, respectively. About 95.5% of the subjects would undergo the treatment again. All implants integrated successfully and demonstrated healthy clinical conditions. Conclusion Lateral wall sinus augmentation using DBBM as the only filling material is a viable treatment concept given limited graft resorption, good patients' tolerance, and clinical outcomes.

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The influence of bone marrow aspirates and concentrates on the early volume stability of maxillary sinus grafts with deproteinized bovine bone mineral – first results of a RCT

Abstract: An evident decrease in graft volume over the first 6 months of healing has to be expected irrespectively of graft composite. Neither BMA nor BMAC seem to have an evident impact. Overaugmentation seems recommendable in two-stage maxillary sinus surgery.

Cited by 17 publications

References 18 publications

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

The Influence of Particulated Autogenous Bone on the Early Volume Stability of Maxillary Sinus Grafts with Biphasic Calcium Phosphate: A Randomized Clinical Trial

A 2‐year prospective case series on volumetric changes, PROMs, and clinical outcomes following sinus floor elevation using deproteinized bovine bone mineral as filling material

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